ID  A1A4S6;
PN  Rho GTPase-activating protein 10;
GN  ARHGAP10;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Association to cell membrane is dependent on PH domain. {ECO:0000250}.
DR  UNIPROT: A1A4S6;
DR  UNIPROT: A1L0S5;
DR  UNIPROT: Q2VPC4;
DR  UNIPROT: Q2VPC5;
DR  UNIPROT: Q96EV3;
DR  UNIPROT: Q96S75;
DR  PDB: 2MIO;
DR  Pfam: PF00169;
DR  Pfam: PF00620;
DR  Pfam: PF14604;
DR  PROSITE: PS50003;
DR  PROSITE: PS50238;
DR  PROSITE: PS50002;
DR  OMIM: 609746;
DR  DisGeNET: 79658;
DE  Function: GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). {ECO:0000250, ECO:0000269|PubMed:11432776}.
DE  Reference Proteome: Yes;
DE  Interaction: Q6P5Z2; IntAct: EBI-1390955; Score: 0.68
DE  Interaction: P78314; IntAct: EBI-10692719; Score: 0.49
DE  Interaction: Q92625; IntAct: EBI-10697254; Score: 0.37
DE  Interaction: Q9C009; IntAct: EBI-11321694; Score: 0.35
DE  Interaction: Q9UNA1; IntAct: EBI-11898726; Score: 0.00
DE  Interaction: Q9ULB1; IntAct: EBI-11898717; Score: 0.00
DE  Interaction: Q9Y426; IntAct: EBI-21517999; Score: 0.35
DE  Interaction: C9J6V4; IntAct: EBI-21517948; Score: 0.35
DE  Interaction: P46013; IntAct: EBI-20562326; Score: 0.35
DE  Interaction: Q02539; IntAct: EBI-20937220; Score: 0.40
DE  Interaction: P03372; IntAct: EBI-21302175; Score: 0.35
DE  Interaction: Q14289; IntAct: EBI-28941112; Score: 0.35
DE  Interaction: Q05209; IntAct: EBI-27116319; Score: 0.27
GO  GO:0005829;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0005096;
GO  GO:0007010;
GO  GO:0043066;
GO  GO:0051056;
GO  GO:0007165;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKFAHSLRDFKFEFIGDAVTDDE
SQ  RCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHL
SQ  QEADIQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFE
SQ  GTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKAAKKFNMIPFEHRSGGKLGDGEVFF
SQ  LKECTKRHTDSIDRRFCFDIEAADRPGVSLTMQAFSEEERKQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIR
SQ  KCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYELHGDFI
SQ  VPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQN
SQ  IVVEILIENHEKIFRTPPDTTFPEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTPTSSLDS
SQ  LSSPSPVTTAVPGPPGPDKNHLLADGGSFGDWASTIPGQTRSSMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATV
SQ  ADKPPESIRSRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL
//