ID  A1A5P9;
PN  Melanoma-associated antigen E1;
GN  Magee1;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}. Note=In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, colocalizes with DTNA in the Schwann cell membrane (By similarity). {ECO:0000250}.
DR  UNIPROT: A1A5P9;
DR  Pfam: PF01454;
DR  PROSITE: PS50838;
DE  Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
GO  GO:0030425;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0045211;
GO  GO:0000122;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSLVSQNSRRRRGGRANGRKNSGKGRPAAVPGPAVPRDRSDPQILQGLGATEGPGTSVLPTPRGGSSTSVPPTASEGSSA
SQ  PGQLITSEGRNTSQLPTSRKGRGTRRPPAVSAGLNAAASITASEGASTPVLPTAPKGSKASEHLTISEGASISEQPQSHE
SQ  GPNVQPTLGEGSGTSVPPTFSEESGISEPLPSGEGLSISVSPTISEGAGINEPSPASKAPSTSVPPTASNGLGINLPPTS
SQ  SEGLSISVLFSASEESDISVPPPSAEGLSTSMPPPSGEVQSTWVPPIILEGCSVKVRSTSRKGRRTPVRSAACESPSPSA
SQ  ECLSTSLSSISAEGFCSSLAPCAEGSDTCELLPCGEGPSTSGLHDLEEESSISQMPLAAEGPSASGSSIEDENPEEALSC
SQ  GASVGMNLCKCTSLALQKADDPSVRPKRAEGFLDFQVLRDSENSNSITIMGLGTAHVALTLKPQDPMEQNVAELLQFLLL
SQ  KDQTKYPIKESEMREFIVQEYRNQFPEILRRAAAHLECIFRFELKELDPEEHTYILLNKLGPVPFEGLEDIPNGPKMGLL
SQ  MMILGQIFLNGNQAREADIWEMLWRFGVQRERRLSVFGNPKRLLSVEFVWQRYLDYRPITDCVPVEYEFYWGPRSHVETT
SQ  KMKILKFMARIYNKDPMDWPAQYNEALEEEAERDVPNNWRAVPHFRRPLFQEVSPELLASDSDAPGCPSKYSPHSWPESR
SQ  LESKSRKLVQLFLLMDSTKLPIPKKGILYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYTLYNRREMEDME
SQ  EIMDSPNRPGNNFLMQVLSFIFIMGNHARESAVWAFLRGLGVQNGRKHVITCRYLSQRYIDSLRVPDSDPVQYDFVWGPR
SQ  ARLETSKMKALRYVARIHRKEPQDWPDQYREALEDEANRAEAGRRPLVVRNLR
//