ID  A1YER2;
PN  Oxidoreductase HTATIP2;
GN  HTATIP2;
OS  9595;
SL  Nucleus Position: SL-0178;
SL  Comments: Cytoplasm {ECO:0000250}. Nucleus envelope {ECO:0000250}.
DR  UNIPROT: A1YER2;
DR  Pfam: PF13460;
DE  Function: Oxidoreductase required for tumor suppression. NADPH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005635;
GO  GO:0016491;
GO  GO:0004674;
GO  GO:0001525;
GO  GO:0006915;
GO  GO:0030154;
GO  GO:0051170;
GO  GO:0043068;
GO  GO:0045944;
GO  GO:0046777;
GO  GO:0045765;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAETEALSKLREDFRMQNKSVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTFDEEAYKNVNQEVVDFEKLDDYAS
SQ  AFQGHDVGFCCLGTTRGKAGAEGFVRVDRDYVLKSAELAKAGGCKHFNLLSSKGADKSSKFLYLQVKGEVEAKVEELKFD
SQ  RYSVFRPGVLLCDRQESRPGEWLVRKFFGSLPESWASGHSVPVVTVVRAMLNNVVRPRDKQMELLENKAIHDLGKAHGSL
SQ  KP
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