ID  A1YK02;
PN  Nuclear pore complex protein Nup75;
GN  Nup75;
OS  7227;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q9BW27}. Nucleus membrane {ECO:0000250|UniProtKB:Q9BW27}.
DR  UNIPROT: A1YK02;
DR  UNIPROT: Q8SZH5;
DR  Pfam: PF07575;
DE  Function: Component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (By similarity). Required for nuclear import of phosphorylated Mad via importin msk (PubMed:20547758). Has no role in classical nuclear localization signal (cNLS)-dependent nuclear import via importin-beta (PubMed:20547758). Facilitates the interaction between Nup93 and sec13 with msk (PubMed:20547758). {ECO:0000250|UniProtKB:Q9BW27, ECO:0000269|PubMed:20547758}.
DE  Reference Proteome: Yes;
DE  Interaction: Q8T0S6; IntAct: EBI-211888; Score: 0.00
DE  Interaction: Q9VX05; IntAct: EBI-226125; Score: 0.00
DE  Interaction: Q9VXS4; IntAct: EBI-244905; Score: 0.00
DE  Interaction: Q9VDI5; IntAct: EBI-249597; Score: 0.00
DE  Interaction: P39769; IntAct: EBI-254420; Score: 0.00
DE  Interaction: Q9W087; IntAct: EBI-256716; Score: 0.00
DE  Interaction: Q9VR15; IntAct: EBI-269063; Score: 0.00
DE  Interaction: Q7K0E3; IntAct: EBI-269271; Score: 0.00
DE  Interaction: Q03017; IntAct: EBI-279084; Score: 0.00
DE  Interaction: Q7JYZ0; IntAct: EBI-279088; Score: 0.00
DE  Interaction: Q9VLT9; IntAct: EBI-279092; Score: 0.00
DE  Interaction: Q9VLP3; IntAct: EBI-279096; Score: 0.00
DE  Interaction: Q9VZU6; IntAct: EBI-505546; Score: 0.00
DE  Interaction: P18431; IntAct: EBI-9950635; Score: 0.35
GO  GO:0031965;
GO  GO:0031080;
GO  GO:0017056;
GO  GO:0006406;
GO  GO:0045893;
GO  GO:0006606;
GO  GO:2000331;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSDSGVFAFELGDDLATRCGNTLTGVFVPGSRIALSAYRHVTHSSRDEPTENAGQVPVLIYMAQESTLFDEPVLRSVLAE
SQ  ANATFATLQQLGSRATRAEYVNISRAYRSIVRSCLEKLEQAKKSPEVQTDEARLQRLCDAIVVFYAAECLWHLFEILYIQ
SQ  SNQLVVPQLLDWARFHSPHAEDRATDLLLMGEEASESDDYWSIVKSLIMLGEIDVTRAVLSQNRKAGQTSFKAAEQILKS
SQ  MPVYQEGYALQKFHSQWEFWHVDTERKIQSGLFATEPELEQLIRLVAGDSEQWDAGIKESQDFYEYLPGYLLFTKPTCKP
SQ  FELKIAAAKWLNRWCLLRPEREQCSMNRMVSQLMDHDLRLFIYDAQKLNDTHWFSTHLIDLIHHCGQLKSYFDQNNIDLP
SQ  ALRHSMIYEYGSYLMTSHNMWQLGIDYLDCCKQEGQAAIELLLPRITLRSERQATKLINLARQRGLISVEREICKVLSKR
SQ  SYDNERYGNALEWAIRSKDVLLVTAVADFILKHYSKTGCMLCPDTIANVGGRMFASPRLVFLSKYFEFYEFYRTRDFLSA
SQ  SELLVNLLESKITPDYFWPSLLIDSMPLLESKDPKIFAKETVAILHHIETDLVPIIERDVSKYGKHHTETVFKDYRVENV
SQ  DEIMNLLRLACARNLARALIIENTLPVV
//