ID  A2A6M5;
PN  Calcium-binding and coiled-coil domain-containing protein 2;
GN  Calcoco2;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q13137}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q13137}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:Q13137}; Peripheral membrane protein {ECO:0000305}.
DR  UNIPROT: A2A6M5;
DR  UNIPROT: Q3TK36;
DR  UNIPROT: Q3TKZ6;
DR  UNIPROT: Q3TL30;
DR  UNIPROT: Q9CWE3;
DR  Pfam: PF17751;
DE  Function: Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity). Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (By similarity). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen- containing autophagosome maturation (By similarity). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (By similarity). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (By similarity). {ECO:0000250|UniProtKB:Q13137}.
DE  Reference Proteome: Yes;
GO  GO:0005776;
GO  GO:0000421;
GO  GO:0005737;
GO  GO:0031410;
GO  GO:0005856;
GO  GO:0005829;
GO  GO:0043231;
GO  GO:0048471;
GO  GO:0016605;
GO  GO:0042803;
GO  GO:1901098;
GO  GO:0034341;
GO  GO:0098792;
TP  Membrane Topology: Peripheral; Source: UniProt - Curator Inference {ECO:0000305};
SQ  MDQCPIPTLLEHGNFSQVLFNNVEKFYAPRGDIMCYYTLTEKFIPRRKDWIGIFKVGWKTTQEYYTFMWAPLPKDQNKDS
SQ  ATQQEIQFKAYYLPKDVERYQFCYVDEDGLVRGTSVPFQFCPDPDEDIMVVINKEKVEEMEQLSEELYQQNQELKDKYAD
SQ  LHEQLQRKQVALEATQRVNKTLEHKVEEKASWEKEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKAS
SQ  WEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEKEKASWEEEKASWEKEKAPWEVEKAPWKE
SQ  VKAYWWNDLHR
//