ID  A2A8U2;
PN  Transmembrane protein 201;
GN  Tmem201;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: [Isoform 2]: Nucleus inner membrane {ECO:0000250|UniProtKB:Q5SNT2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5SNT2}. Note=The C-terminal of isoform 2 is located on the nucleoplasmic side. During interphase, isoform 2 is distributed in the inner nuclear membrane and during mitosis, it is found in the ER but it also localizes to the polar regions of the mitotic spindle (By similarity). {ECO:0000250|UniProtKB:Q5SNT2}.
DR  UNIPROT: A2A8U2;
DR  UNIPROT: Q3U5F3;
DR  UNIPROT: Q6GQS9;
DR  UNIPROT: Q8BNY3;
DR  Pfam: PF10476;
DR  Pfam: PF09779;
DE  Function: Involved in nuclear movement during fibroblast polarization and migration (PubMed:22349700). May recruit Ran GTPase to the nuclear periphery (By similarity). {ECO:0000250|UniProtKB:Q5SNT2, ECO:0000269|PubMed:22349700}. [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle. Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina. {ECO:0000250|UniProtKB:Q5SNT2}. [Isoform 3]: Proposed to be involved in actin-dependent nuclear movement; via SUN2 associates with transmembrane actin- associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow. {ECO:0000305|PubMed:22349700}.
DE  Reference Proteome: Yes;
DE  Interaction: Q8BJS4; IntAct: EBI-12591483; Score: 0.54
DE  Interaction: P48678; IntAct: EBI-12591514; Score: 0.40
DE  Interaction: Q6ZWQ0; IntAct: EBI-12596297; Score: 0.27
GO  GO:0032541;
GO  GO:0005639;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0031616;
GO  GO:0051015;
GO  GO:0005521;
GO  GO:0051642;
GO  GO:0010761;
GO  GO:0006998;
GO  GO:0007097;
GO  GO:0030473;
GO  GO:0090435;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MEGVSALLASCPTAGLAGGLGVTACAAAGVVLYRIARRVKPTHTMVNCWFCNHDTLVPYGNRNCWDCPHCEQYNGFQENG
SQ  DYNKPIPAQYMEHLNHVVSSVPSPRDPAQPQQWVSSQVLLCRRCSHHQTTKIKQLAAFTPREEGRYDEEIEVYRHHLEQM
SQ  YKLCRPCQAAVEYYIKHQNRQLRALLLSHQFRRREADQAHGQSFSSSAVKAPFQVILLRALAFLACAFLLFTTLYGPSEP
SQ  FTPGAALPPALPPGGNSSAASDNTTSQAEGWQQLLGLLPEHATEKLHEAWAFGQSHQTSIVAVGLLTCLLAMLLAGRIRL
SQ  RRIDAFSTCLWALLLGLHLAEHYLQAASPGWLDTLKFSTTSLCCLVGFTAAVATRKSTGPRRFRPRRYFSGDSASLFPSS
SQ  PSLAVPYPSVTSSPASLFIPTPPGFLPLTKQQLFRSPRRVSPSSLPGRLSRALSLGTIPPLTRTDSGYLFSGSRPPSRVS
SQ  PAGEVSLSDYFSLLSSSFPASPLPSPAPSVASSVASSSGSLRHRRPLISPARLNLKGQKLLLFSSPGEAPNTPSSSEEFS
SQ  PPNGSLFIESPQLPQRNHTRDTKHTMEMRSMLARDSARSSHSIKKEDESSQSSTCVVDTTTKGCSEETTPWKARVSPSLV
SQ  RGLLAVSLAVNALFTSAYLYQSLR
//