ID  A8CG34;
PN  Nuclear envelope pore membrane protein POM 121C;
GN  POM121C;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus, nuclear pore complex {ECO:0000269|PubMed:17900573}. Nucleus membrane {ECO:0000269|PubMed:17900573}; Single-pass membrane protein {ECO:0000269|PubMed:17900573}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase. {ECO:0000250}.
DR  UNIPROT: A8CG34;
DR  UNIPROT: A0A075B7F8;
DR  UNIPROT: A0A087WY75;
DR  UNIPROT: O75115;
DR  UNIPROT: Q9Y2N3;
DR  UNIPROT: Q9Y4S7;
DR  OMIM: 615754;
DE  Function: Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}.
DE  Reference Proteome: Yes;
DE  Interaction: Q92731; IntAct: EBI-2880211; Score: 0.35
DE  Interaction: P25054; IntAct: EBI-3437854; Score: 0.00
DE  Interaction: P42229; IntAct: EBI-3943935; Score: 0.37
DE  Interaction: Q05322; IntAct: EBI-6159823; Score: 0.35
DE  Interaction: Q6PFD9; IntAct: EBI-10994876; Score: 0.35
DE  Interaction: Q8BH74; IntAct: EBI-10997196; Score: 0.35
DE  Interaction: Q9ERU9; IntAct: EBI-10999306; Score: 0.35
DE  Interaction: P63280; IntAct: EBI-11044140; Score: 0.35
DE  Interaction: P49790; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q96EE3; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: P12004; IntAct: EBI-11109663; Score: 0.55
DE  Interaction: Q14974; IntAct: EBI-11115566; Score: 0.59
DE  Interaction: P57740; IntAct: EBI-11160436; Score: 0.35
DE  Interaction: Q9NRA8; IntAct: EBI-11898977; Score: 0.00
DE  Interaction: Q504Q3; IntAct: EBI-11898968; Score: 0.00
DE  Interaction: Q2M3V2; IntAct: EBI-11898959; Score: 0.00
DE  Interaction: P42694; IntAct: EBI-11898950; Score: 0.00
DE  Interaction: Q9Y2I1; IntAct: EBI-11940179; Score: 0.00
DE  Interaction: Q9Y4F3; IntAct: EBI-11941734; Score: 0.00
DE  Interaction: Q504Y0; IntAct: EBI-21572157; Score: 0.35
DE  Interaction: P02545; IntAct: EBI-16795756; Score: 0.27
DE  Interaction: P20309; IntAct: EBI-20809896; Score: 0.37
DE  Interaction: Q9Y463; IntAct: EBI-28947247; Score: 0.35
DE  Interaction: P46934; IntAct: EBI-30831805; Score: 0.44
DE  Interaction: Q93009; IntAct: EBI-30840708; Score: 0.44
DE  Interaction: P46937; IntAct: EBI-30845790; Score: 0.44
DE  Interaction: O95600; IntAct: EBI-29020196; Score: 0.35
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0005654;
GO  GO:0008139;
GO  GO:0017056;
GO  GO:0051028;
GO  GO:0006606;
GO  GO:0006405;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MSPAAAAAGAGERRRPIASVRDGRGRGCGGPAGAALLGLSLVGLLLYLVPAAAALAWLAVGTTAAWWGLSREPRGSRPLS
SQ  SFVQKARHRRTLFASPPAKSTANGNLLEPRTLLEGPDPAELLLMGSYLGKPGPPQPAPAPEGQDLRNRPGRRPPARPAPR
SQ  STPPSQPTHRVHHFYPSLPTPLLRPSGRPSPRDRGTLPDRFVITPRRRYPIHQTQYSCPGVLPTVCWNGYHKKAVLSPRN
SQ  SRMVCSPVTVRIAPPDRRFSRSAIPEQIISSTLSSPSSNAPDPCAKETVLSALKEKKKKRTVEEEDQIFLDGQENKRRRH
SQ  DSSGSGHSAFEPLVASGVPASFVPKPGSLKRGLNSQSSDDHLNKRSRSSSMSSLTGAYTSGIPSSSRNAITSSYSSTRGI
SQ  SQLWKRNGPSSSPFSSPASSRSQTPERPAKKIREEELCHHSSSSTPLAADKESQGEKAADTTPRKKQNSNSQSTPGSSGQ
SQ  RKRKVQLLPSRRGEQLTLPPPPQLGYSITAEDLDLEKKASLQWFNQALEDKSDAASNSVTETPPTTQPSFTFTLPAAATA
SQ  SPPTSLLAPSTNPLLESLKKMQTPPSLPPCPESAGAATTEALSPPKTPSLLPPLGLSQSGPPGLLPSPSFDSKPPTTLLG
SQ  LIPAPSMVPATDTKAPPTLQAETATKPQATSAPSPAPKQSFLFGTQNTSPSSPAAPAASSASPMFKPIFTAPPKSEKEGL
SQ  TPPGPSVSATAPSSSSLPTTTSTTAPTFQPVFSSMGPPASVPLPAPFFKQTTTPATAPTTTAPLFTGLASATSAVAPITS
SQ  ASPSTDSASKPAFGFGINSVSSSSVSTTTSTATAASQPFLFGAPQASAASFTPAMGSIFQFGKPPALPTTTTVTTFSQSL
SQ  PTAVPTATSSSAADFSGFGSTLATSAPATSSQPTLTFSNTSTPTFNIPFGSSAKSPLPSYPGANPQPAFGAAEGQPPGAA
SQ  KPALTPSFGSSFTFGNSAAPAPATAPTPAPASTIKIVPAHVPTPIQPTFGGATHSAFGLKATASAFGAPASSQPAFGGST
SQ  AVFSFGAATSSGFGATTQTASSGSSSSVFGSTTPSPFTFGGSAAPAGSGSFGINVATPGSSATTGAFSFGAGQSGSTATS
SQ  TPFTGGLGQNALGTTGQSTPFAFNVGSTTESKPVFGGTATPTFGQNTPAPGVGTSGSSLSFGASSAPAQGFVGVGPFGSA
SQ  APSFSIGAGSKTPGARQRLQARRQHTRKK
//