ID  A8X3V8;
PN  Tyrosine 3-monooxygenase;
GN  cat;
OS  6238;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P24529}. Cell projection, axon {ECO:0000250|UniProtKB:P24529}. Note=Expressed in dopaminergic axons and axon terminals. {ECO:0000250|UniProtKB:P24529}.
DR  UNIPROT: A8X3V8;
DR  Pfam: PF00351;
DR  PROSITE: PS00367;
DR  PROSITE: PS51410;
DE  Function: Involved in the synthesis of catecholamines, such as dopamine. Has a role in serotonin signaling. Required for normal explorative and foraging behavior (By similarity). {ECO:0000250|UniProtKB:P90986}.
DE  Reference Proteome: Yes;
GO  GO:0030424;
GO  GO:0005737;
GO  GO:0043204;
GO  GO:0048471;
GO  GO:0005506;
GO  GO:0004511;
GO  GO:0007610;
GO  GO:0006585;
GO  GO:0042136;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSSLTNPTTVMEEEEVPVAAPIRRGNKNPRRYSLVHQASCETQHHIGIRRQNTIQHRKQLTDQMREQKILQQLNDEGVEV
SQ  IFAANDVSSIDFSVIVTSTDYISTFVSDILYNMKSAGVQICHVETRESKAVSGHDVLLDCRATKNQLIKAAELLTQNHVA
SQ  LTHFSIFSKKSVEKSQSMIWFPRHISELDQCSKCITKYEPTTDPRHPGHGDDEYIARRKFLNDQALEFKFGDEIGYVEYT
SQ  EDEHATWKAVYEKLGGLHESHTCSVYRQNLKILQKEKVLTADRIPQIRDVNKFLQKKTGFELRPCSGLLSARDFLASLAF
SQ  RVFQTTTYLRHHKSPHHSPEPDLIHELLGHVPMFSDPLLAQMSQDIGLMSLGASDEHIEKLATVYWFIVEFGLCKEDGKL
SQ  KAIGAGLLSAYGELIHACSDAPEHKDFDPAVTAIQKYEDDDYQPLYFVADSIHDALAKLRKYASSMDRPFSVVYDPFTKS
SQ  IETIQSSADLEKAFSRLSNDLSAITHAADRMKISITA
//