ID  B1WBD7;
PN  Ubiquitin carboxyl-terminal hydrolase 20;
GN  usp20;
OS  8355;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
DR  UNIPROT: B1WBD7;
DR  Pfam: PF06337;
DR  Pfam: PF00443;
DR  Pfam: PF02148;
DR  PROSITE: PS51283;
DR  PROSITE: PS00972;
DR  PROSITE: PS00973;
DR  PROSITE: PS50235;
DR  PROSITE: PS50271;
DE  Function: Deubiquitinating enzyme involved in beta-2 adrenergic receptor (adrb2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (adrb2). Plays a central role in adrb2 recycling and resensitization after prolonged agonist stimulation by constitutively binding adrb2, mediating deubiquitination of adrb2 and inhibiting lysosomal trafficking of adrb2. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
GO  GO:0005813;
GO  GO:0048471;
GO  GO:0004843;
GO  GO:0004197;
GO  GO:0008270;
GO  GO:0006897;
GO  GO:0016579;
GO  GO:0071108;
GO  GO:0070536;
GO  GO:0008277;
GO  GO:0006511;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MADAEDFCPHLDSIGEVTKEDLILKSKGTCESCGVGGPNLWACLQDGCQSVGCGESYADHSTLHAQDFPSPAHPLKSVPI
SQ  AVGDDGESESDEDDIKPRGLTGMKNIGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDKKPALCKSYQKLVSELWHKKR
SQ  PSYVVPSSLYHGIKLINPLFRGYSQQDTQEFLRCLMDQLHEELKEPILPENQEQEEEERDDQREGERGGTTEEDFLSCDS
SQ  GGEMGDGEGGGGVGTLSEMELLIREEVGRGLSEKEKLKERKLSYCHRRTSSEQADEDADVDTAMIPEPDNDAYMHCSSRS
SQ  CSPHPVESISKHSSTPPRSSPLRTAHSYVLKKAQVLSGGKKRSEVRYRSVISDIFDGSILSLVQCLTCDRVSTTIETFQD
SQ  LSLPIPGKEDLAKLHSTIHQSTVIKAGTCGDSYAAQGWLAFVMDYIRRFVVSCIPSWFWGPMITLEDCLAAFFAADELKG
SQ  DNMYSCERCKKLRNGVKYCKVLRLPEVLCIHLKRFRHEVMYSFKIGSHVSFPLEGLNLRPFLAKECVSRITTYDLLAVIC
SQ  HHGSASSGHYISYCQNVINGQWYEFDDQYVTEVHETVVQNAEAYVLFYRKSSEEAERERQKVVSLAAMKESGLLQFYISR
SQ  EWLNKFNTFAEPGPISNQSFLCAHGGIPPNKYHYIDDLVVILPQSVWEYLYNRFGGGPAVNHLYVCSICQVEIEALAKRR
SQ  KTEIDTFIKLNKAFQAEEAPSVIYCISMQWFREWEAFVKAKDSDPPGPIDNSKVALTKSSGHVQLKQGADYGQISEETWN
SQ  YLLNIYGGGPEIAIRQTVAQYQDPEHLHGEQKIEAETRAG
//