ID  B9X187;
PN  Nuclear envelope integral membrane protein 1a;
GN  nemp1a;
OS  8355;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus inner membrane {ECO:0000269|PubMed:19167377, ECO:0000269|PubMed:25946333}; Multi-pass membrane protein; Nucleoplasmic side {ECO:0000269|PubMed:19167377}. Nucleus envelope {ECO:0000269|PubMed:19167377}. Note=Localization in the nuclear membrane is essential for its function. Colocalizes with lamins and banf1-a/b at the nuclear envelope. {ECO:0000269|PubMed:19167377, ECO:0000269|PubMed:25946333}.
DR  UNIPROT: B9X187;
DR  UNIPROT: Q0IH41;
DR  Pfam: PF10225;
DE  Function: In concert with ran, required for proper eye development (PubMed:25946333). May be involved in the expression of early eye marker genes (PubMed:19167377). Contributes to nuclear envelope stiffness in germ cells (By similarity). Required for fertility (By similarity). {ECO:0000250|UniProtKB:O14524, ECO:0000269|PubMed:19167377, ECO:0000269|PubMed:25946333}.
DE  Reference Proteome: Yes;
DE  Interaction: A1L3G9; IntAct: EBI-12597651; Score: 0.40
DE  Interaction: P52301; IntAct: EBI-12596100; Score: 0.40
DE  Interaction: Q66KV4; IntAct: EBI-12596342; Score: 0.46
GO  GO:0016021;
GO  GO:0005635;
GO  GO:0005637;
GO  GO:0043621;
GO  GO:0001654;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MAGDVEGGGCRVSWGALLTLLLLPLPSLCTLASGKEPHVIKLYEGKVVRYNESKNFCYQRTYEPKWSDVWTKIQIRVNST
SQ  KMIRVTQVENEEKLKEMETFNMFDLFSSFLKEKLNDTFIYVDLYSNKTCIKVHVIDTDTYYSVALSRGFDPRLCFLFLCG
SQ  LLLFFYGDALSRSQLFFYSTGITIGMLASMLILVFMLSKLMPKKSPFVALLLGGWSVSIYIIQLVFKNLQAICSEYWQYL
SQ  LGYLGIVGFVSFAFCYKYGPLENDRSINILTWTLQLIGLLLMYISVQIQHIAVTMVVIAFCTKQIEYPVQWIYILYRKIK
SQ  RKRAKPSPPRLLTEEEYRKQGEIETRKALEELRGYCSSPDFATWKMISRIQSPKRFADFVEGSSHLTPNEVSVHEHEYGL
SQ  GGSFLEDELFGEDSDIEVEMDIEQPLYLVPRSCF
//