ID  D3YYU8;
PN  Obscurin-like protein 1;
GN  Obsl1;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250|UniProtKB:O75147}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O75147}. Golgi apparatus {ECO:0000250|UniProtKB:O75147}. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons. {ECO:0000250|UniProtKB:O75147}.
DR  UNIPROT: D3YYU8;
DR  UNIPROT: F7AD47;
DR  UNIPROT: Q80WA6;
DR  Pfam: PF07679;
DR  PROSITE: PS50853;
DR  PROSITE: PS50835;
DE  Function: Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Acts as a regulator of the Cul7- RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
GO  GO:1990393;
GO  GO:0005813;
GO  GO:0005737;
GO  GO:0005794;
GO  GO:0048471;
GO  GO:0045202;
GO  GO:0007030;
GO  GO:0007156;
GO  GO:0000226;
GO  GO:0050775;
GO  GO:0034067;
GO  GO:0007088;
GO  GO:0010842;
GO  GO:0007416;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MKAGSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPTVVWEKGGQQLVASERLSFPEDGAEHGLLLSGALPTDAG
SQ  VYVCRARNAAGEAYAAAAVTVLEPPAPEPEPESSECPLPTPGTGEGAPKFLTGPQSQWVLRGEEVVLTCQVGGLPEPKLY
SQ  WEKDGMALDEVWDSSHFKLEPGRGASDEGASLTLRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPRESPPQDPDEN
SQ  PKPVLEPLKGAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHLEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCA
SQ  ARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIVVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGAVRRLVIH
SQ  KLKADDDGVYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETQEAGVQGCWSRDGEDLPDTCQSSCGHMH
SQ  ALVLPGVTREDAGEITFSLGNSRTTTLLRVKCVKHSPPGPPVMVEMFKGQKNKVLLTWKPPEPPPETSFIYRLERQEVGS
SQ  DDWIQCFSIEKAGAVEVPGDCVPTEGDYHFRICTVSEHGRSPHVVFNGSAHLVPTARLVSGLEDVQVYDGEDAVFSLDLS
SQ  AIIQGSWFLNGEQLQSNEPEGQVEPGALRYRIEQKGLQHRLILQAVKHRDSGALVGFSCPGVQDSAALTIQESSVHILSP
SQ  QDKVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESESLIVKTEGRKHRLILPEAQVRDSGEFECRTEGVSAFFGVT
SQ  VQDPPVHIVNPQEHVFVHAITSECVRLTCEVDREDTTVHWYKDGQEVEESDIIVLENKGPHHRLVLPAARPSDGGEFQCV
SQ  AGDERAYFTVTITDVFSWIVYPSSEVHVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLEKEDTIRRLVLPSV
SQ  QLEDSGEYLCEIHDESASFTITVTEPPVRIIYPQDEVTLHAVSLECVVLTCELSREDAPVRWYKDGLEVEESEALVLQSD
SQ  GPRRRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLQFGAPGHVELRCEVAPAGSQVRWYKDGLE
SQ  VEVSDALQLGAEGPARTLTLPHAQPEDAGEYVCETRDEAVTFNVSLAELPVQFLAPEAAPNPLCVVPGEPVVLSCELSRA
SQ  SAQVFWSHNGSPVQQGEGLELRAEGPRRILCIQAADLAHTGVYTCQSGASPGAPSLSFNVQVAELPPVKLVSELTPLTVH
SQ  EGDDATFQCEVSPPDAEVTWLRNGAVITAGPQLEMVQNGSSRTLIIRGCQLKDAGTVTARAGAADTSARLHVRETELLFL
SQ  RRLQDVRAEEGQDVHLEVETGRVGAAGTVRWIRGGEPLPLDSRLTTAQDGHVHRLSIHGVLLTDQGTYGCESRHDRTLAR
SQ  LSVRPRQLRELRPLEDVTVHEGGSATFQLELSQEGVTGEWAQGGVRLHPGPKCHIQSEGRTHRLVLSGLGLADSGCVSFT
SQ  ADTLRCAARLTVREVPVTIVQGPQDLEVTEGDTATFECELSQTLADVIWEKDGQALSLSPRLRLQALGTRRLLLLRRCCS
SQ  SDAGTYSCVVGTARSEPARLTVREREVSVLRELRSVSAREGDGATFECTVSETEITGRWELGGRALRPGGRVRIRQEGKK
SQ  HILVLSELRTEDTGEVCFQAGPAQSLARLEVEALPLQMCRRPPREKTVLVNRRAVLEVTVSRPGGHVCWMREGVELCPGN
SQ  KYETRRHGTTHSLVIHDVRPEDQGTYSCQAGQDSADTQLLVDGD
//