ID  E9PSK7;
PN  C-Jun-amino-terminal kinase-interacting protein 3;
GN  Mapk8ip3;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250|UniProtKB:Q9ESN9}. Golgi apparatus {ECO:0000250|UniProtKB:Q9ESN9}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9ESN9}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9ESN9}. Cell projection, axon {ECO:0000269|PubMed:21775604, ECO:0000269|PubMed:23576431}. Cell projection, dendrite {ECO:0000269|PubMed:21775604}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21775604}. Note=Localized in the soma and growth cones of differentiated neurites and the Golgi and vesicles of the early secretory compartment of epithelial cells. KIF5A/B/C-mediated transportation to axon tips is essential for its function in enhancing neuronal axon elongation. {ECO:0000250|UniProtKB:Q9ESN9, ECO:0000269|PubMed:23576431}.
DR  UNIPROT: E9PSK7;
DR  UNIPROT: B0VXR4;
DR  Pfam: PF16471;
DR  Pfam: PF09744;
DR  PROSITE: PS51776;
DR  PROSITE: PS51777;
DE  Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development. Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation. {ECO:0000250|UniProtKB:Q9ESN9, ECO:0000269|PubMed:21076496, ECO:0000269|PubMed:21775604, ECO:0000269|PubMed:23576431, ECO:0000269|PubMed:25944905}.
DE  Reference Proteome: Yes;
GO  GO:0030673;
GO  GO:0030424;
GO  GO:1904115;
GO  GO:0044297;
GO  GO:0005737;
GO  GO:0031410;
GO  GO:0030425;
GO  GO:0000139;
GO  GO:0030426;
GO  GO:0043005;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0005790;
GO  GO:0008432;
GO  GO:0019894;
GO  GO:0005078;
GO  GO:0031434;
GO  GO:0031435;
GO  GO:0030159;
GO  GO:0099641;
GO  GO:0061564;
GO  GO:0007411;
GO  GO:0031103;
GO  GO:0030900;
GO  GO:0001701;
GO  GO:0007254;
GO  GO:0048286;
GO  GO:0060425;
GO  GO:0043066;
GO  GO:0031175;
GO  GO:0046330;
GO  GO:0043507;
GO  GO:0045666;
GO  GO:2001224;
GO  GO:0009791;
GO  GO:0008104;
GO  GO:0050821;
GO  GO:0010468;
GO  GO:0046328;
GO  GO:0007585;
GO  GO:0016192;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVEL
SQ  ELLREDNEQLLTQYEREKALRKQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKE
SQ  YNALHQRHTEMIQTYVEHIERSKMQQVGGGGQTESSLPGRSRKERPTSLNVFPLADGMVRAQMGGKLVPAGDHWHLSDLG
SQ  QLQSSSSYQCPNDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGSVTKNNKRAREKRNSRNMEV
SQ  QVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDVCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDE
SQ  GADLLGEFSGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLKGELEAAKQAKVKLENRIKELEEELKR
SQ  VKSEAVTARREPREEVEDDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQ
SQ  FFSRLFSSSSSPPPAKRSYPSVNIHYKSPTTAGFSQRRNHALCQISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHV
SQ  RNDDGRLQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPSTKLWCAAGVNLSGWKPNEEDSSNGPKPAPG
SQ  RDPLTCDREGEGEPKSTHPSPEKKKAKEVPEADATSSRVWILTSTLTTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIP
SQ  AASDSDYPPGDMFLDSDVNPEDSGADGVLAGITLVGCATRCNVPRSNCSSRGDTPVLDKGQGDVAATANGKVNPSQSTEE
SQ  ATEATEVPDPGPSESEATTVRPGPLTEHVFTDPAPTQSSSTQPASENGSESDGSIVQPQVEPSGESSATTSSAAPTMWLG
SQ  AQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAV
SQ  VDDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKM
SQ  LGTGKLGFSFVRITALLIAGNRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGTRPGGIIHVYGDDSSDK
SQ  TASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDSPSEGPGPAAPAADAEGQKLKNALVLSGGEGYIDF
SQ  RIGDGEDDETEEGTGDVNQTKPSLSKAERSHIIVWQVSYTPE
//