ID  F1M4A4;
PN  Kinesin-like protein KIF1A;
GN  Kif1a;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q12756}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q12756}. Cell projection, axon {ECO:0000250|UniProtKB:P33173}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P33173}. Synapse {ECO:0000250|UniProtKB:P33173}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane {ECO:0000269|PubMed:29166604, ECO:0000269|PubMed:30021165}; Peripheral membrane protein {ECO:0000305|PubMed:30021165}; Cytoplasmic side {ECO:0000305|PubMed:30021165}. Note=Within neuronal cells concentrated in the axon, with smaller amounts in the perinuclear and synaptic regions (By similarity). Expressed in distal regions of neurites. {ECO:0000250|UniProtKB:P33173, ECO:0000250|UniProtKB:Q12756}.
DR  UNIPROT: F1M4A4;
DR  Pfam: PF12473;
DR  Pfam: PF00498;
DR  Pfam: PF12423;
DR  Pfam: PF00225;
DR  Pfam: PF16183;
DR  Pfam: PF00169;
DR  PROSITE: PS50006;
DR  PROSITE: PS00411;
DR  PROSITE: PS50067;
DR  PROSITE: PS50003;
DE  Function: Motor for anterograde axonal transport of synaptic vesicle precursors (Probable). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons (PubMed:29166604, PubMed:30021165). The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites (PubMed:30021165). {ECO:0000269|PubMed:29166604, ECO:0000269|PubMed:30021165, ECO:0000305}.
DE  Reference Proteome: Yes;
DE  Interaction: A0A142I9X8; IntAct: EBI-11701393; Score: 0.50
GO  GO:0070161;
GO  GO:0030424;
GO  GO:1904115;
GO  GO:0005829;
GO  GO:0030425;
GO  GO:0098674;
GO  GO:0005871;
GO  GO:0005874;
GO  GO:0043005;
GO  GO:0043025;
GO  GO:0098992;
GO  GO:0048471;
GO  GO:0098794;
GO  GO:0098793;
GO  GO:0032991;
GO  GO:0008021;
GO  GO:0005524;
GO  GO:0016887;
GO  GO:0042802;
GO  GO:0008017;
GO  GO:0003777;
GO  GO:0008574;
GO  GO:0008089;
GO  GO:1990048;
GO  GO:0030705;
GO  GO:0099519;
GO  GO:0022027;
GO  GO:0007018;
GO  GO:0098840;
GO  GO:0060998;
GO  GO:0061001;
GO  GO:1990049;
GO  GO:0016192;
TP  Membrane Topology: Peripheral; Source: UniProt - Curator Inference {ECO:0000305|PubMed:30021165};
SQ  MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHTSPEDINYASQKQVYRDIGEE
SQ  MLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNP
SQ  KNKGNLRVREHPLLGPYVEDLSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEK
SQ  VSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLG
SQ  GNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDITDTNTVPGG
SQ  PKLTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAE
SQ  MGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGVTRVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGG
SQ  EAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQRELLEKQG
SQ  IDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAF
SQ  RKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQD
SQ  QKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDRFPWFRLVGRAFVYLSNLLYPVPLVHRVA
SQ  IVSEKGEVKGFLRVAVQAISADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGA
SQ  DAGPSADEVNNNTCSAVPPEGLLDSPEKAALDGPLDTALDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEA
SQ  FSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKP
SQ  VPATKLSTMTRPSPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRWK
SQ  EVRELVVGRIRNTPETDEALIDPNILSLNILSSGYVHPAQDDRQFLDSDIPRTFYQFEAAWDSSMHNSLLLNRVTPYREK
SQ  IYMTLSAYIEMENCTQPAVITKDFCMVFYSRDAKLPASRSIRNLFGSGSLRATEGNRVTGVYELSLCHVADAGSPGMQRR
SQ  RRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELEKLSLLQEVEKTRHYLLLREKLETTQRPVPEVLSPASSEDSESR
SQ  SSSGASSPLSAEGQPSPLEVPNERQRELAVKCLRLLMHTFNREYTHSHVCISASESKLSEMSVTLMRDPSMSPLGAATLT
SQ  PSSTCPSLIEGRYGATDVRTPQPCSRPASPEPELLPELDSKKTPSPVRATETEKEPQRLLVPDIQEIRVSPIVSKKGYLH
SQ  FLEPHTAGWAKRFVVVRRPYAYMYNSDKDTVERFVLNLSTAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQANSDKDMHD
SQ  WLYAFNPLLAGTIRSKLSRRRSAQMRV
//