ID  F4IMH3;
PN  Protein NUCLEOLAR COMPLEX ASSOCIATED 4;
GN  NOC4;
OS  3702;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus membrane {ECO:0000250|UniProtKB:Q9BVI4}; Multi-pass membrane protein {ECO:0000255}. Nucleus, nucleolus {ECO:0000269|PubMed:23382868}.
DR  UNIPROT: F4IMH3;
DR  UNIPROT: O22737;
DR  UNIPROT: Q8VZE1;
DR  Pfam: PF03914;
DE  Function: Essential protein required during embryogenesis (PubMed:15266054, PubMed:23382868). Involved in nucleolar processing of ribosomal RNA (rRNA) 40S and 90S ribosomal subunits and ribosome assembly; early in ribosome biogenesis, especially required during the maturation of 5.8S rRNA (PubMed:23382868). Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q06512, ECO:0000269|PubMed:15266054, ECO:0000269|PubMed:23382868}.
DE  Reference Proteome: Yes;
GO  GO:0016021;
GO  GO:0030692;
GO  GO:0031965;
GO  GO:0005730;
GO  GO:0005654;
GO  GO:0032040;
GO  GO:0009793;
GO  GO:0006364;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MASILSKKQKKNEKYTLKELKSLGHDLLTSRSHINNLPLLLTFVSPESPPQFVVESLLSLQSFFTPLLSQLPPTSSSPSS
SQ  TKTEDPEVVFKAWLRSKFDEFVKLLLDVLVSQQSEDSLRGIVLGTLMEFVKLLNAGRFHSSIYHRLLDAIIHSEVDIEIF
SQ  LDILTSKYFKYIDVRYFTYISMEKFVKTLEASVSADRTVIENNEAESDSKESLELSVRKIYQVLSQIPPPEKQAEKSQHE
SQ  MWSGSDESISEKPTDKKKKTEKGDSTLLSPATISKRMKLKFTKAWISFLRLPLPIDVYKEVLASIHLTVIPHLSNPTMLC
SQ  DFLTKSYDIGGVVSVMALSSLFILMTQHGLEYPFFYEKLYALLVPSVFVAKHRAKFLQLLDACLKSSMLPAYLAASFTKK
SQ  LSRLSLSIPPAGSLVITALIYNLLRRNPTINHLVQEIVENADEANTEAGEHNESQPKTIKKRKLGIDYFNNQESDPKKSG
SQ  ALKSSLWEIDTLRHHYCPPVSRFISSLETNLTIRSKTTEMKIEDFCSGSYATIFGDEIRRRVKQVPLAFYKTVPTSLFAD
SQ  SDFPGWTFTIPQEEGTC
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