ID  G5EFV8;
PN  Vacuolar protein sorting-associated protein 52 homolog;
GN  vps;
OS  6239;
SL  Nucleus Position: SL-0198;
SL  Comments: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:21613545}. Perikaryon {ECO:0000269|PubMed:27191843}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:27191843}. Note=Co-localizes with rab-2 to perinuclear puncta in the perikaryon. Co-localizes with the small GTPases rab-6.1 and rab-6.2 at Golgi structures (PubMed:21613545). {ECO:0000269|PubMed:21613545, ECO:0000269|PubMed:27191843}.
DR  UNIPROT: G5EFV8;
DR  UNIPROT: G5EFV9;
DR  Pfam: PF04129;
DE  Function: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN) (PubMed:21613545). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (PubMed:21613545). Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1 (PubMed:27191843). Important for neuronal function (PubMed:27191843). {ECO:0000269|PubMed:21613545, ECO:0000269|PubMed:27191843}.
DE  Reference Proteome: Yes;
DE  Interaction: O01839; IntAct: EBI-2411813; Score: 0.73
DE  Interaction: Q09501; IntAct: EBI-335600; Score: 0.00
DE  Interaction: P32743; IntAct: EBI-335609; Score: 0.00
DE  Interaction: O61975; IntAct: EBI-335606; Score: 0.00
DE  Interaction: Q20742; IntAct: EBI-335603; Score: 0.00
DE  Interaction: Q22227; IntAct: EBI-335612; Score: 0.00
DE  Interaction: Q22544; IntAct: EBI-335615; Score: 0.00
DE  Interaction: P91820; IntAct: EBI-335621; Score: 0.00
DE  Interaction: P34574; IntAct: EBI-335618; Score: 0.00
DE  Interaction: Q9N575; IntAct: EBI-335624; Score: 0.00
DE  Interaction: Q22639; IntAct: EBI-6398967; Score: 0.54
DE  Interaction: P34561; IntAct: EBI-6395189; Score: 0.54
DE  Interaction: Q22782; IntAct: EBI-6399389; Score: 0.46
DE  Interaction: P34213; IntAct: EBI-6399381; Score: 0.46
DE  Interaction: G5EFV8; IntAct: EBI-6398996; Score: 0.37
DE  Interaction: Q20797; IntAct: EBI-6399555; Score: 0.37
DE  Interaction: H2KZ72; IntAct: EBI-6399559; Score: 0.37
DE  Interaction: P41941; IntAct: EBI-6399538; Score: 0.37
DE  Interaction: Q21499; IntAct: EBI-6399564; Score: 0.37
GO  GO:0005829;
GO  GO:0000938;
GO  GO:0005797;
GO  GO:0000138;
GO  GO:0043204;
GO  GO:0048471;
GO  GO:0031267;
GO  GO:0019905;
GO  GO:0032456;
GO  GO:0006896;
GO  GO:0007041;
GO  GO:1904810;
GO  GO:1904811;
GO  GO:0090326;
GO  GO:0015031;
GO  GO:0042147;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MPRTRVNLQKSEANDRSFTISSLEFCLSQLRKADPNLVKKAIASGDGLTESKNDVSTRLSEAHRYSVQQCLDNSEQLAQL
SQ  HNQLVHCDNVFERLQATLYSFQDNLGSIGQDMKNLQLQSHHIHQELENRQKVRVELSQFVDDIAVSQTMMKTINDTDAND
SQ  RGFLEALHELHHKITLILQRGNGDAVAVNDTMPILEGLKLKAVVKVREWLLQKMFQFRKPLSNYQVFQHQLLKCRFFYEF
SQ  LLHHDLISAKELQDEYIDTISKMFFTYFKAYATRLFKLAMKDVATKEDALGSIDFAKPAGLGAIFSSKQHVVRNKATVFS
SQ  IGQRHQILSDDFLGALIVPHAATQNHQSYQFEALFRSIQLAFVDHYSHEYLFITDFFLVSNDEAIELHNKAMARAMSVVL
SQ  KSCEEQIALSWDAISLHLCICLCDKFTEVLAEREVPEVSDYWNTVTSFLWTRLNLVMSQHYESVKSVDLKKLMHSGSLDA
SQ  RPHFIVRRYAELTSAHLMIAKASGKEMGAKMEAVLENSEDSIEQLLTRMSAMQQTQKNKHVFLINNYDLILSIIDNEESK
SQ  HTKIYAIVHELEQKSIDDFVEEMLEPHIGYMIKFVNECESLIVQGHTQLLVRYNDKVGTVVANFNAKWRPAVDSINSECI
SQ  QLFTNFSLGTTILQTIFTKYVQYINRFTKILSHDVFAKNPVCSQLVNVHQVMLEIKRFKPAY
//