ID  H2KZB2;
PN  Ankyrin repeat and LEM domain-containing protein 2 homolog;
GN  lem;
OS  6239;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus membrane {ECO:0000269|PubMed:22770216}; Single-pass membrane protein {ECO:0000269|PubMed:22770216}.
DR  UNIPROT: H2KZB2;
DR  UNIPROT: Q5W7E5;
DR  PROSITE: PS50297;
DR  PROSITE: PS50088;
DE  Function: Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of baf-1 during mitotic exit. Coordinates the control of baf-1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of baf-1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. {ECO:0000269|PubMed:22770216}.
DE  Reference Proteome: Yes;
DE  Interaction: Q03565; IntAct: EBI-6258976; Score: 0.44
DE  Interaction: Q19848; IntAct: EBI-6258976; Score: 0.56
GO  GO:0005783;
GO  GO:0016021;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0051721;
GO  GO:0051301;
GO  GO:0007084;
GO  GO:0042326;
GO  GO:0035307;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MGRKSAILAVILAIIYFRSNFSKMSNTPVQETEGPVYVAYSMEDMLKSPRDLYKSVKEVAKFVNSAEGKSMSARFKKFGT
SQ  PREAMDFLAYGDAPTTPKTVPPVAPTEPNSPFSGVNRIQMNEFKKYVEKGDMENFLRLVDSNPRFLVNTGGDVASIVMEG
SQ  FRYNALHIAAKAGQTEIIAKILELIQNIDFLIRLYGTGADDVTLRKINILDSYLNTPDKGNSDTPLHFASKFGKIGVVRV
SQ  LTENSATDRTLLNKSGKSALDCAGERYTGEDKDMVQRDIHLAIEGFYVFLHRNPTTGSTQLTVSQKPPATYSTSPTTATV
SQ  TVSAQAGPFFTEREARDFAKSWQTAGKELKRTDFDKGWERVGRVLAEQSEAMWRETWHFLGSMELLDLGSEQGLGVLEAF
SQ  LREKRRGNLRNSEISEISTKKSIFRRGIHARKLDFGILDGEKSAEISENLTPDGSDSADDEDDDDIFYDTFSEIPAAAEK
SQ  SINDPDDTLGSLTDRFAAISIFSPLPPPPPPQWSNSPNFDYSEGEDSFATPPTTPPPTFVADDEPCKIDNDLFEVLAQIS
SQ  SELISKFPLTQDYVQKLGKLTAHDRSTWRPIDSPARCDSRRKI
//