ID  M9PBE2;
PN  E3 ubiquitin-protein ligase Hakai;
GN  Hakai;
OS  7227;
SL  Nucleus Position: SL-0198;
SL  Comments: Nucleus {ECO:0000305}. Cell membrane {ECO:0000305|PubMed:19682089}. Cytoplasmic vesicle {ECO:0000305|PubMed:19682089}. Cytoplasm, perinuclear region {ECO:0000305|PubMed:19682089}.
DR  UNIPROT: M9PBE2;
DR  UNIPROT: Q86NQ9;
DR  UNIPROT: Q8INV9;
DR  UNIPROT: Q8INW0;
DR  UNIPROT: Q95RE3;
DR  UNIPROT: Q9VIT1;
DR  Pfam: PF18408;
DR  PROSITE: PS00518;
DR  PROSITE: PS50089;
DE  Function: E3 ubiquitin-protein ligase required during early development (PubMed:19682089). E3 ubiquitin-protein ligases mediate ubiquitination of target proteins (PubMed:19682089). Required for epithelial integrity and midgut morphogenesis (PubMed:19682089). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189). Its function in the WMM complex is unknown (PubMed:29535189). {ECO:0000250|UniProtKB:Q75N03, ECO:0000250|UniProtKB:Q9JIY2, ECO:0000269|PubMed:19682089, ECO:0000305|PubMed:29535189}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9VU72; IntAct: EBI-198772; Score: 0.00
DE  Interaction: A1Z9X0; IntAct: EBI-200042; Score: 0.00
DE  Interaction: Q9VI24; IntAct: EBI-200115; Score: 0.00
DE  Interaction: Q9VI16; IntAct: EBI-200123; Score: 0.00
DE  Interaction: Q24558; IntAct: EBI-200119; Score: 0.00
DE  Interaction: P25171; IntAct: EBI-200127; Score: 0.00
DE  Interaction: Q7KTX7; IntAct: EBI-200132; Score: 0.00
DE  Interaction: Q9W2M4; IntAct: EBI-200136; Score: 0.00
DE  Interaction: Q9VU89; IntAct: EBI-200140; Score: 0.00
DE  Interaction: Q9VU18; IntAct: EBI-200144; Score: 0.00
DE  Interaction: Q9VI55; IntAct: EBI-200148; Score: 0.00
DE  Interaction: Q8T0I9; IntAct: EBI-200152; Score: 0.00
DE  Interaction: Q9V472; IntAct: EBI-200156; Score: 0.00
DE  Interaction: Q4Z8K6; IntAct: EBI-200160; Score: 0.00
DE  Interaction: Q9VGB9; IntAct: EBI-200164; Score: 0.00
DE  Interaction: Q9V9R6; IntAct: EBI-200172; Score: 0.00
DE  Interaction: Q9VN36; IntAct: EBI-200176; Score: 0.00
DE  Interaction: Q9VRC3; IntAct: EBI-200180; Score: 0.00
DE  Interaction: Q9XZU1; IntAct: EBI-200184; Score: 0.00
DE  Interaction: Q9VSQ3; IntAct: EBI-200188; Score: 0.00
DE  Interaction: Q9VC48; IntAct: EBI-200192; Score: 0.00
DE  Interaction: Q9VMS5; IntAct: EBI-200196; Score: 0.00
DE  Interaction: Q8MYW5; IntAct: EBI-200200; Score: 0.00
DE  Interaction: Q9VGU7; IntAct: EBI-200204; Score: 0.00
DE  Interaction: Q9W550; IntAct: EBI-200208; Score: 0.00
DE  Interaction: Q9VZT6; IntAct: EBI-200212; Score: 0.00
DE  Interaction: P54356; IntAct: EBI-200216; Score: 0.00
DE  Interaction: Q9VJE3; IntAct: EBI-200220; Score: 0.00
DE  Interaction: Q9VJ53; IntAct: EBI-200224; Score: 0.00
DE  Interaction: Q9VXD4; IntAct: EBI-200228; Score: 0.00
DE  Interaction: Q9VMD4; IntAct: EBI-200232; Score: 0.00
DE  Interaction: Q9VFU6; IntAct: EBI-200236; Score: 0.00
DE  Interaction: Q9VCM3; IntAct: EBI-200240; Score: 0.00
DE  Interaction: Q8T3Y1; IntAct: EBI-200244; Score: 0.00
DE  Interaction: B7YZT2; IntAct: EBI-200248; Score: 0.00
DE  Interaction: Q9V9V8; IntAct: EBI-200252; Score: 0.00
DE  Interaction: Q9VVV6; IntAct: EBI-200256; Score: 0.00
DE  Interaction: Q9VF73; IntAct: EBI-200260; Score: 0.00
DE  Interaction: P42282; IntAct: EBI-200264; Score: 0.00
DE  Interaction: Q9W3J9; IntAct: EBI-200268; Score: 0.00
DE  Interaction: Q9V9V0; IntAct: EBI-200272; Score: 0.00
DE  Interaction: O46070; IntAct: EBI-200276; Score: 0.00
DE  Interaction: Q9W5B6; IntAct: EBI-200280; Score: 0.00
DE  Interaction: Q9VEA5; IntAct: EBI-200284; Score: 0.00
DE  Interaction: M9MRI4; IntAct: EBI-200288; Score: 0.00
DE  Interaction: Q9VKQ0; IntAct: EBI-200292; Score: 0.00
DE  Interaction: Q9V4B8; IntAct: EBI-200296; Score: 0.00
DE  Interaction: Q9VZM9; IntAct: EBI-200300; Score: 0.00
DE  Interaction: Q9VSB2; IntAct: EBI-200304; Score: 0.00
DE  Interaction: Q9VPE1; IntAct: EBI-200308; Score: 0.00
DE  Interaction: Q9VQF9; IntAct: EBI-200313; Score: 0.00
DE  Interaction: A1ZAC8; IntAct: EBI-200317; Score: 0.00
DE  Interaction: Q9VDC1; IntAct: EBI-200321; Score: 0.00
DE  Interaction: Q9W1R5; IntAct: EBI-200325; Score: 0.00
DE  Interaction: Q9VSY2; IntAct: EBI-200329; Score: 0.00
DE  Interaction: P11455; IntAct: EBI-200333; Score: 0.00
DE  Interaction: Q9Y156; IntAct: EBI-200337; Score: 0.00
DE  Interaction: Q9VAZ1; IntAct: EBI-200345; Score: 0.00
DE  Interaction: Q8IQB8; IntAct: EBI-200341; Score: 0.00
DE  Interaction: Q9VD25; IntAct: EBI-200349; Score: 0.00
DE  Interaction: Q7K4Z4; IntAct: EBI-200353; Score: 0.00
DE  Interaction: Q94981; IntAct: EBI-200357; Score: 0.00
DE  Interaction: O76924; IntAct: EBI-200361; Score: 0.00
DE  Interaction: O97365; IntAct: EBI-200365; Score: 0.00
DE  Interaction: Q7JXC4; IntAct: EBI-200369; Score: 0.00
DE  Interaction: P23696; IntAct: EBI-200373; Score: 0.00
DE  Interaction: Q9V460; IntAct: EBI-200377; Score: 0.00
DE  Interaction: A1Z8L7; IntAct: EBI-200382; Score: 0.00
DE  Interaction: Q9VLP3; IntAct: EBI-200386; Score: 0.00
DE  Interaction: Q9VHR4; IntAct: EBI-200390; Score: 0.00
DE  Interaction: Q7K127; IntAct: EBI-200394; Score: 0.00
DE  Interaction: Q9VHG0; IntAct: EBI-200398; Score: 0.00
DE  Interaction: Q8T3X9; IntAct: EBI-200402; Score: 0.00
DE  Interaction: Q9VHA9; IntAct: EBI-200406; Score: 0.00
DE  Interaction: Q9V428; IntAct: EBI-200410; Score: 0.00
DE  Interaction: Q9W379; IntAct: EBI-200414; Score: 0.00
DE  Interaction: Q9W5X1; IntAct: EBI-200418; Score: 0.00
DE  Interaction: Q9VXE7; IntAct: EBI-200422; Score: 0.00
DE  Interaction: P22810; IntAct: EBI-26730114; Score: 0.49
GO  GO:0031410;
GO  GO:0005829;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0036396;
GO  GO:0045296;
GO  GO:0061630;
GO  GO:0004842;
GO  GO:0008270;
GO  GO:0007015;
GO  GO:0040003;
GO  GO:0007391;
GO  GO:0007427;
GO  GO:0060429;
GO  GO:0030237;
GO  GO:0008258;
GO  GO:0007494;
GO  GO:0080009;
GO  GO:0016567;
GO  GO:0000381;
GO  GO:0030155;
GO  GO:0035282;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MDTEEVKRGRGRGRGTRARGRGRGRGRGRGKKIDDSSIADAAALAASSCAALEDSPGRLDASEDSVMQELDKDGELETPG
SQ  ALEEPLPHGALGAVAASGNMTPATQQPQVLQQVPPPVMSQTTISLSLARAVDMEADISQLEAPTFTTLSRGPPEPMLRLK
SQ  WNHKVSLIGEKVLNPMIHCCDQCDKPILVYGRMIPCKHVFCLKCARAEPIKSCPRCTDKVLRVEQSGLGTVFMCTHGGSR
SQ  YGSSGCRRTYLSQRDLQAHINHRHVAPQPPPLQPQPQLSAMAEQPKMTDLGGVGLGLELHKQRKLSESSVPISVSASIAS
SQ  RPVLSRLPLTGGVGNIGSIGSIPPPGSAAAAQNAIHGGHSTLTLANLTRINNANAQECHQGKASLHHTLKKGTPHQSESV
SQ  ADASYYSSVLASFGSAAGNPGSGPPGGGATAAAQPANPSGSHSAVGPGALIGGSTDAPTGGSSGNWQQSQYYR
//