ID  O01477;
PN  Protein simr-1;
GN  simr;
OS  6239;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:32338603}. Note=Localizes to perinuclear foci in germ cells, called SIMR foci, which are distinct from Mutator foci, P granules and Z granules (PubMed:32338603). SIMR foci are stacked, with znfx-1 localizing between simr-1 and pgl-1 (PubMed:32338603). Its localization at SIMR foci is adjacent to the mutator complex protein mut-16 (PubMed:32338603). Perinuclear localization is not dependent on mut-16 (PubMed:32338603). {ECO:0000269|PubMed:32338603}.
DR  UNIPROT: O01477;
DE  Function: Acts downstream of piRNA production to promote mediator complex-dependent endogenous siRNA biogenesis from piRNA-target mRNAs in the RNA interference pathway in germ cells (PubMed:32338603). Not required to identify target mRNA by the piRNA pathway (PubMed:32338603). Plays a role in both spermatogenesis and oogenesis and in maintaining fertility over multiple generations, probably by directing mutator-dependent silencing to piRNA-targeted genes (PubMed:32338603). {ECO:0000269|PubMed:32338603}.
DE  Reference Proteome: Yes;
GO  GO:0048471;
GO  GO:0090727;
GO  GO:1905881;
GO  GO:0030422;
GO  GO:0007283;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSNEKQQWDDAYCLAEEMHDAGRPFKREELNIADQFICSRFSTIFEYDPYKDTYGFRNQELTHAIPVKSKCRHISDVDIL
SQ  ELKKNTANADIRFPSYLNICPVYAMHPFTVLAFDLSKPVPMGMNASMENAAPNMKSPTEAEITPGTIYIFKHRDNKCYRC
SQ  VILFEDGDNNVSDADRKYMVAFLDTPQVVSVKLKTLFHLGKFTIESYPCALYCCRAVGILEIRKDFGADLNGQINEFYKD
SQ  KVKRKSGVHALIYKKDDRGDKLIFDCPSILGTSMTMALEIKDVIGHRSVAENDPTALSYDELVSKQLPTVDIDDHNSSVV
SQ  LDLEESVIAQELGSTNGADCPCNNDNIDDFMQSQRQNPLDNNRDNWDRINESRSSMQSFAINQSQAITANPTPQPTFDES
SQ  SGEVQTIPESINNLALNGRYLEDGRGTEEIREERSVESRQIGNQVVSQASCNYLEARQNSTQTANAESVCAIISESHAAL
SQ  PTDIQVIPSQHVLNENNHTVLPSVAPIIRNATGHSHIFGRQIPSPAFRRESLSSGNSIQVATFAATTGPCGSNTSRPTAQ
SQ  NTANSSINQDMSISNSSTNARLITIAQDNLNDTENWPNSEREQSATEMESGAEATTNSAVDEFAQVSDDMKGLADSMINF
SQ  LRLTANSNNQDAFKANIFAMELISTKIPNQLTKRFFTLKIAEAKSLAEGFN
//