ID  O02824;
PN  Alpha-1A adrenergic receptor;
GN  ADRA1A;
OS  9986;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:P35348}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:P35348}. Membrane, caveola {ECO:0000250|UniProtKB:P35348}. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK- mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes (By similarity). {ECO:0000250}.
DR  UNIPROT: O02824;
DR  Pfam: PF00001;
DR  PROSITE: PS00237;
DR  PROSITE: PS50262;
DE  Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
GO  GO:0005901;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0016021;
GO  GO:0031965;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0005886;
GO  GO:0004937;
GO  GO:0046982;
GO  GO:0007512;
GO  GO:0061049;
GO  GO:0000165;
GO  GO:0010259;
GO  GO:0010507;
GO  GO:0001985;
GO  GO:0150099;
GO  GO:0001994;
GO  GO:0007200;
GO  GO:0097195;
GO  GO:0010613;
GO  GO:0001996;
GO  GO:0043410;
GO  GO:1903997;
GO  GO:0045987;
GO  GO:0001997;
GO  GO:0055117;
GO  GO:0019229;
TP  Membrane Topology: Transmembrane; Source: UniProt - By Similarity {ECO:0000250};
SQ  MVFLSGNASDSSNCTHPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVL
SQ  PFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIISLCVISIDRYIGVSYPLRYPTIVTQRRGLRALLCVWAFSLVISVG
SQ  PLFGWRQPAPDDETICQINEEPGYVLFSALGSFYVPLTIILAMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
SQ  APAGGSGVASAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPPETVFKIVFWLGYLNSC
SQ  INPIIYPCSSQEFKKAFQNVLKIQCLRRKQSSKHALGYTLHAPSQALEGQHKDMVRIPVGSGETFYKISKTDGVCEWKFF
SQ  SSMPRGSARITVPKDQSACTTARVRSKSFLQVCCCVGPSTPNPGENHQVPTIKIHTISLSENGEEV
//