ID  O08579;
PN  Emerin;
GN  Emd;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0183;
SL  Comments: Nucleus inner membrane {ECO:0000250|UniProtKB:P50402}; Single-pass membrane protein; Nucleoplasmic side {ECO:0000250|UniProtKB:P50402}. Nucleus outer membrane. Note=Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus (By similarity). {ECO:0000250}.
DR  UNIPROT: O08579;
DR  UNIPROT: Q3TIH6;
DR  UNIPROT: Q3UJP3;
DR  Pfam: PF03020;
DR  PROSITE: PS50954;
DE  Function: Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta- catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1- dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non- farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells. {ECO:0000250|UniProtKB:P50402}.
DE  Reference Proteome: Yes;
DE  Interaction: P20263; IntAct: EBI-3043810; Score: 0.35
DE  Interaction: P52927; IntAct: EBI-9986179; Score: 0.35
DE  Interaction: Q8NF91; IntAct: EBI-10760599; Score: 0.27
DE  Interaction: Q8WXH0; IntAct: EBI-10760623; Score: 0.27
DE  Interaction: Q9NRI5; IntAct: EBI-26612017; Score: 0.35
GO  GO:0032541;
GO  GO:0005737;
GO  GO:0005783;
GO  GO:0016021;
GO  GO:0005874;
GO  GO:0005635;
GO  GO:0005637;
GO  GO:0005652;
GO  GO:0031965;
GO  GO:0005640;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0005819;
GO  GO:0031616;
GO  GO:0003779;
GO  GO:0048487;
GO  GO:0071363;
GO  GO:0090090;
GO  GO:0048147;
GO  GO:0071763;
GO  GO:0046827;
GO  GO:0060828;
GO  GO:0035914;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MDDYAVLSDTELAAVLRQYNIPHGPIVGSTRKLYEKKIFEYETQRRRLLPPNSSSSSFSYQFSDLDSAAVDSDMYDLPKK
SQ  EDALLYQSKDYNDDYYEESYLTTKTYGEPESVGMSKSFRQPGTSLVDADTFHHQVRDDIFSSLEEEGKDRERLIYGQDSA
SQ  YQSIAHYRPISNVSRSSLGLSYYPTSSTSSVSSSSSSPSSWLTRRAIRPEKQAPAAALGQDRQVPLWGQLLLFLVFAAFL
SQ  LFVYYSIQAEEGNPFWMDP
//