ID  O13066;
PN  Ran GTPase-activating protein 1;
GN  rangap1;
OS  8355;
SL  Nucleus Position: SL-0178;
SL  Comments: Cytoplasm {ECO:0000250|UniProtKB:P46060}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P46060}. Nucleus envelope {ECO:0000250|UniProtKB:P46060}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:P46060}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P46060}. Note=Cytoplasmic during interphase. Detected at the nuclear envelope during interphase. Targeted to the nuclear pores after sumoylation. During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles. Mitotic location also requires sumoylation. {ECO:0000250|UniProtKB:P46060}.
DR  UNIPROT: O13066;
DR  Pfam: PF13516;
DR  Pfam: PF07834;
DE  Function: GTPase activator for RAN, converting it to the GDP-bound state (PubMed:9108047). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is required for RAN-mediated nuclear import and export (By similarity). {ECO:0000250|UniProtKB:P46060, ECO:0000269|PubMed:9108047}.
DE  Reference Proteome: Yes;
GO  GO:0005737;
GO  GO:0000776;
GO  GO:0005635;
GO  GO:0005654;
GO  GO:0005819;
GO  GO:0005096;
GO  GO:0007165;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAAEDIAQLADCLAKANVGDGELSFKGKTLKLNTAQDAEEVIREIEEYEGLQALRLEGNTVGVEAAKAIAEVLQRKPDLK
SQ  RCHWSDMFTGRLRPEIPTALRSLGDALITAGAQLTELDLSDNAFGPDGVRGFEALLKSPTCFTLQELKLNNCGMGIGGGK
SQ  ILAAALTECHKKSSAHGKPLALKVFIAGRNRLENDGATALSEAFRLIGTLEEVHMPQNGINHAGITALAESFKANSLLKV
SQ  INLNDNTFTEKGGVAMAEALKTLRQVEVINFGDCLVRSKGAQAIASALKEGLHKLKDLNLSYCEIKADAAVSLAESVEDK
SQ  SDLEKLDLNGNCLGEEGCEQVQEILESINMANILGSLSDDEDEDDDDDDEDDDDDEDDENDDEEVEEEEEEVEEEEGGDN
SQ  ENKEKSKEIPCLSGSAPASPPKLPVDASTFLSFPSPEKLVRMGPRRSAMIAQQVNVADTEKVVQAFIQVSSVYREDGEIK
SQ  AAVEETIDGLMKEAFENRGFQANVFITSLLVQMGLLKSEDKMKTIPHLNGPLLTLNHMVQQNYFPKSLASTLLAFISKPN
SQ  GVLENNASARHTLLCNLHNL
//