ID  O14524;
PN  Nuclear envelope integral membrane protein 1;
GN  NEMP1;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus inner membrane {ECO:0000250|UniProtKB:Q6ZQE4}; Multi-pass membrane protein {ECO:0000255}; Nucleoplasmic side {ECO:0000250|UniProtKB:B9X187}. Nucleus envelope {ECO:0000250|UniProtKB:Q6ZQE4}. Note=Colocalizes with lamins and RAN-GTP at the nuclear envelope. {ECO:0000250|UniProtKB:Q6ZQE4}.
DR  UNIPROT: O14524;
DR  UNIPROT: Q17R72;
DR  UNIPROT: Q68DH0;
DR  UNIPROT: Q6IQ25;
DR  Pfam: PF10225;
DR  OMIM: 616496;
DR  DisGeNET: 23306;
DE  Function: Together with EMD, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). Required for female fertility (By similarity). {ECO:0000250|UniProtKB:Q6ZQE4, ECO:0000269|PubMed:32923640}.
DE  Reference Proteome: Yes;
DE  Interaction: A0A6H3AKG3; IntAct: EBI-2826538; Score: 0.00
DE  Interaction: Q12952; IntAct: EBI-11318689; Score: 0.35
DE  Interaction: Q8BH74; IntAct: EBI-10997196; Score: 0.35
DE  Interaction: Q9ERU9; IntAct: EBI-10999306; Score: 0.35
DE  Interaction: P63280; IntAct: EBI-11044140; Score: 0.35
DE  Interaction: Q14974; IntAct: EBI-11115566; Score: 0.35
DE  Interaction: Q6ZNC8; IntAct: EBI-11121915; Score: 0.35
DE  Interaction: Q9Y6G1; IntAct: EBI-24659878; Score: 0.56
DE  Interaction: Q86UF1; IntAct: EBI-24660066; Score: 0.56
DE  Interaction: Q15848; IntAct: EBI-23677731; Score: 0.56
DE  Interaction: Q96PS8; IntAct: EBI-24670298; Score: 0.56
DE  Interaction: A0PK11; IntAct: EBI-24685606; Score: 0.56
DE  Interaction: P54315; IntAct: EBI-24691337; Score: 0.56
DE  Interaction: Q9BXN2; IntAct: EBI-23735883; Score: 0.56
DE  Interaction: Q5BJF2; IntAct: EBI-24702243; Score: 0.56
DE  Interaction: P01031; IntAct: EBI-24710670; Score: 0.56
DE  Interaction: Q69YG0; IntAct: EBI-23757171; Score: 0.56
DE  Interaction: Q8NBD8; IntAct: EBI-23775909; Score: 0.56
DE  Interaction: Q86Y82; IntAct: EBI-24726194; Score: 0.56
DE  Interaction: Q9Y5U4; IntAct: EBI-24727065; Score: 0.56
DE  Interaction: Q5BVD1; IntAct: EBI-23788982; Score: 0.56
DE  Interaction: O75841; IntAct: EBI-23811148; Score: 0.56
DE  Interaction: Q07325; IntAct: EBI-23826105; Score: 0.56
DE  Interaction: Q9NPR9; IntAct: EBI-24757439; Score: 0.56
DE  Interaction: Q02747; IntAct: EBI-24769561; Score: 0.56
DE  Interaction: Q8TBE1; IntAct: EBI-24778423; Score: 0.56
DE  Interaction: Q8N661; IntAct: EBI-23881612; Score: 0.56
DE  Interaction: Q15836; IntAct: EBI-24784453; Score: 0.56
DE  Interaction: Q14162; IntAct: EBI-25284656; Score: 0.56
DE  Interaction: Q5QGT7; IntAct: EBI-25286161; Score: 0.56
DE  Interaction: Q96IV6; IntAct: EBI-24746528; Score: 0.56
DE  Interaction: P07306; IntAct: EBI-24775456; Score: 0.56
DE  Interaction: Q71RG4; IntAct: EBI-24788045; Score: 0.56
DE  Interaction: P29400; IntAct: EBI-25202447; Score: 0.56
DE  Interaction: P60033; IntAct: EBI-24799557; Score: 0.56
DE  Interaction: Q6PL45; IntAct: EBI-25271145; Score: 0.56
DE  Interaction: Q8N6R1; IntAct: EBI-25271350; Score: 0.56
DE  Interaction: P62826; IntAct: EBI-21557447; Score: 0.35
DE  Interaction: P61769; IntAct: EBI-21675069; Score: 0.35
DE  Interaction: Q9Y2X3; IntAct: EBI-21695903; Score: 0.35
DE  Interaction: Q9NVU7; IntAct: EBI-21695903; Score: 0.35
DE  Interaction: Q99666; IntAct: EBI-21695903; Score: 0.35
DE  Interaction: Q709F0; IntAct: EBI-21695903; Score: 0.35
DE  Interaction: P0DJD1; IntAct: EBI-21695903; Score: 0.35
DE  Interaction: Q15398; IntAct: EBI-21695903; Score: 0.35
DE  Interaction: P78356; IntAct: EBI-21695903; Score: 0.35
DE  Interaction: P63279; IntAct: EBI-21695903; Score: 0.35
DE  Interaction: P50579; IntAct: EBI-21695903; Score: 0.35
DE  Interaction: P49792; IntAct: EBI-21695903; Score: 0.35
DE  Interaction: P48426; IntAct: EBI-21695903; Score: 0.35
DE  Interaction: P48167; IntAct: EBI-21695903; Score: 0.35
DE  Interaction: P46060; IntAct: EBI-21695903; Score: 0.35
DE  Interaction: O60503; IntAct: EBI-21695903; Score: 0.35
DE  Interaction: O14715; IntAct: EBI-21695903; Score: 0.35
DE  Interaction: P27824; IntAct: EBI-16789004; Score: 0.35
DE  Interaction: Q92630; IntAct: EBI-28952196; Score: 0.27
DE  Interaction: Q8NCK7; IntAct: EBI-27103180; Score: 0.35
DE  Interaction: P35712; IntAct: EBI-29730925; Score: 0.27
DE  Interaction: P48436; IntAct: EBI-29732788; Score: 0.27
GO  GO:0016021;
GO  GO:0005635;
GO  GO:0005637;
GO  GO:0071763;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MAGGMKVAVSPAVGPGPWGSGVGGGGTVRLLLILSGCLVYGTAETDVNVVMLQESQVCEKRASQQFCYTNVLIPKWHDIW
SQ  TRIQIRVNSSRLVRVTQVENEEKLKELEQFSIWNFFSSFLKEKLNDTYVNVGLYSTKTCLKVEIIEKDTKYSVIVIRRFD
SQ  PKLFLVFLLGLMLFFCGDLLSRSQIFYYSTGMTVGIVASLLIIIFILSKFMPKKSPIYVILVGGWSFSLYLIQLVFKNLQ
SQ  EIWRCYWQYLLSYVLTVGFMSFAVCYKYGPLENERSINLLTWTLQLMGLCFMYSGIQIPHIALAIIIIALCTKNLEHPIQ
SQ  WLYITCRKVCKGAEKPVPPRLLTEEEYRIQGEVETRKALEELREFCNSPDCSAWKTVSRIQSPKRFADFVEGSSHLTPNE
SQ  VSVHEQEYGLGSIIAQDEIYEEASSEEEDSYSRCPAITQNNFLT
//