ID  O14657;
PN  Torsin-1B;
GN  TOR1B;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Endoplasmic reticulum lumen {ECO:0000269|PubMed:15147511}. Nucleus membrane {ECO:0000269|PubMed:15147511}.
DR  UNIPROT: O14657;
DR  Pfam: PF06309;
DR  OMIM: 608050;
DR  DisGeNET: 27348;
DE  Function: May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non- neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues. {ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}.
DE  Reference Proteome: Yes;
DE  Interaction: P16104; IntAct: EBI-2564373; Score: 0.35
DE  Interaction: A2APR8; IntAct: EBI-11001201; Score: 0.35
DE  Interaction: Q8IWL3; IntAct: EBI-13943458; Score: 0.35
DE  Interaction: A4D1S0; IntAct: EBI-21511461; Score: 0.35
DE  Interaction: P20036; IntAct: EBI-21511890; Score: 0.35
DE  Interaction: Q9UBM8; IntAct: EBI-21514186; Score: 0.35
DE  Interaction: P32971; IntAct: EBI-21604933; Score: 0.35
DE  Interaction: Q9NRD1; IntAct: EBI-21685297; Score: 0.35
DE  Interaction: Q9UG22; IntAct: EBI-21694248; Score: 0.35
DE  Interaction: P29016; IntAct: EBI-21693940; Score: 0.35
DE  Interaction: Q9BRR6; IntAct: EBI-21694151; Score: 0.35
DE  Interaction: Q9H3K2; IntAct: EBI-21899782; Score: 0.35
DE  Interaction: Q9H0V9; IntAct: EBI-21899782; Score: 0.35
DE  Interaction: Q5JTV8; IntAct: EBI-15853118; Score: 0.40
DE  Interaction: P0DTC3; IntAct: EBI-25686340; Score: 0.35
DE  Interaction: P0DTC8; IntAct: EBI-25687968; Score: 0.35
DE  Interaction: P0DTD1; IntAct: EBI-27050247; Score: 0.35
GO  GO:0005783;
GO  GO:0005788;
GO  GO:0070062;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0005524;
GO  GO:0016887;
GO  GO:0042802;
GO  GO:0019894;
GO  GO:0051085;
GO  GO:0007029;
GO  GO:0071763;
GO  GO:0034504;
GO  GO:0006986;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MLRAGWLRGAAALALLLAARVVAAFEPITVGLAIGAASAITGYLSYNDIYCRFAECCREERPLNASALKLDLEEKLFGQH
SQ  LATEVIFKALTGFRNNKNPKKPLTLSLHGWAGTGKNFVSQIVAENLHPKGLKSNFVHLFVSTLHFPHEQKIKLYQDQLQK
SQ  WIRGNVSACANSVFIFDEMDKLHPGIIDAIKPFLDYYEQVDGVSYRKAIFIFLSNAGGDLITKTALDFWRAGRKREDIQL
SQ  KDLEPVLSVGVFNNKHSGLWHSGLIDKNLIDYFIPFLPLEYRHVKMCVRAEMRARGSAIDEDIVTRVAEEMTFFPRDEKI
SQ  YSDKGCKTVQSRLDFH
//