ID  O14681;
PN  Etoposide-induced protein 2.4 homolog;
GN  EI24;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus membrane {ECO:0000269|PubMed:21154811}; Multi-pass membrane protein {ECO:0000269|PubMed:21154811}. Cytoplasm {ECO:0000269|PubMed:21154811}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
DR  UNIPROT: O14681;
DR  UNIPROT: A8K7D6;
DR  UNIPROT: B4DKL6;
DR  UNIPROT: Q9BUQ1;
DR  OMIM: 605170;
DR  DisGeNET: 9538;
DE  Function: Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity). {ECO:0000250}.
DE  Disease: Note=EI24 is on a chromosomal region frequently deleted in solid tumors, and it is thought to play a role in breast and cervical cancer. Particularly, expression analysis of EI24 in cancerous tissues shows that EI24 loss is associated with tumor invasiveness.
DE  Reference Proteome: Yes;
DE  Interaction: A0A142I5B9; IntAct: EBI-20626169; Score: 0.35
DE  Interaction: P51668; IntAct: EBI-2339419; Score: 0.37
DE  Interaction: P62837; IntAct: EBI-2339474; Score: 0.37
DE  Interaction: P06460; IntAct: EBI-11723082; Score: 0.35
DE  Interaction: P0C739; IntAct: EBI-11725101; Score: 0.35
DE  Interaction: Q6NUS6; IntAct: EBI-11368748; Score: 0.27
DE  Interaction: Q9WMX2; IntAct: EBI-11513187; Score: 0.35
DE  Interaction: P11234; IntAct: EBI-12451925; Score: 0.51
DE  Interaction: P27105; IntAct: EBI-12452286; Score: 0.51
DE  Interaction: Q8N4P2; IntAct: EBI-12452567; Score: 0.51
DE  Interaction: Q9NUH8; IntAct: EBI-24698409; Score: 0.56
DE  Interaction: O15173; IntAct: EBI-24712104; Score: 0.56
DE  Interaction: Q12982; IntAct: EBI-24742623; Score: 0.56
DE  Interaction: Q9UI14; IntAct: EBI-24743382; Score: 0.56
DE  Interaction: Q6PL24; IntAct: EBI-25225021; Score: 0.56
DE  Interaction: Q8IWL3; IntAct: EBI-13943458; Score: 0.35
DE  Interaction: P51685; IntAct: EBI-20804904; Score: 0.37
DE  Interaction: F5H1C8; IntAct: EBI-21264930; Score: 0.35
DE  Interaction: Q9H1C4; IntAct: EBI-21266770; Score: 0.35
DE  Interaction: P01116; IntAct: EBI-27041844; Score: 0.27
DE  Interaction: P01111; IntAct: EBI-27042293; Score: 0.27
DE  Interaction: P01112; IntAct: EBI-27045317; Score: 0.27
DE  Interaction: Q9H5K3; IntAct: EBI-28948637; Score: 0.35
DE  Interaction: Q8NCK7; IntAct: EBI-27103180; Score: 0.35
GO  GO:0005829;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0005794;
GO  GO:0016021;
GO  GO:0016020;
GO  GO:0031965;
GO  GO:0061676;
GO  GO:0006915;
GO  GO:0016236;
GO  GO:0030308;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MADSVKTFLQDLARGIKDSIWGICTISKLDARIQQKREEQRRRRASSVLAQRRAQSIERKQESEPRIVSRIFQCCAWNGG
SQ  VFWFSLLLFYRVFIPVLQSVTARIIGDPSLHGDVWSWLEFFLTSIFSALWVLPLFVLSKVVNAIWFQDIADLAFEVSGRK
SQ  PHPFPSVSKIIADMLFNLLLQALFLIQGMFVSLFPIHLVGQLVSLLHMSLLYSLYCFEYRWFNKGIEMHQRLSNIERNWP
SQ  YYFGFGLPLAFLTAMQSSYIISGCLFSILFPLFIISANEAKTPGKAYLFQLRLFSLVVFLSNRLFHKTVYLQSALSSSTS
SQ  AEKFPSPHPSPAKLKATAGH
//