ID  O14684;
PN  Prostaglandin E synthase;
GN  PTGES;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Membrane {ECO:0000269|PubMed:10377395, ECO:0000269|PubMed:16439136, ECO:0000269|PubMed:18682561, ECO:0000269|PubMed:27684486}; Multi-pass membrane protein {ECO:0000303|PubMed:18682561}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10869354}. Note=Colocalizes with PTGS1/COX-1 and PTGS2/COX-2 in the perinuclear compartment. {ECO:0000269|PubMed:10869354}.
DR  UNIPROT: O14684;
DR  UNIPROT: O14900;
DR  UNIPROT: Q5SZC0;
DR  PDB: 3DWW;
DR  PDB: 4AL0;
DR  PDB: 4AL1;
DR  PDB: 4BPM;
DR  PDB: 4WAB;
DR  PDB: 4YK5;
DR  PDB: 4YL0;
DR  PDB: 4YL1;
DR  PDB: 4YL3;
DR  PDB: 5BQG;
DR  PDB: 5BQH;
DR  PDB: 5BQI;
DR  PDB: 5K0I;
DR  PDB: 5T36;
DR  PDB: 5T37;
DR  PDB: 5TL9;
DR  PDB: 6VL4;
DR  Pfam: PF01124;
DR  OMIM: 605172;
DR  DisGeNET: 9536;
DE  Function: Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:18682561, PubMed:10377395, PubMed:12672824, PubMed:12460774, PubMed:10869354, PubMed:12244105). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 (PubMed:12244105, PubMed:12672824). In addition, displays low glutathione transferase and glutathione- dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed:12672824). {ECO:0000250|UniProtKB:Q9JM51, ECO:0000269|PubMed:10377395, ECO:0000269|PubMed:10869354, ECO:0000269|PubMed:12244105, ECO:0000269|PubMed:12460774, ECO:0000269|PubMed:12672824, ECO:0000269|PubMed:18682561}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9Y3E0; IntAct: EBI-11161387; Score: 0.35
DE  Interaction: Q9H0R3; IntAct: EBI-24674609; Score: 0.56
DE  Interaction: Q04941; IntAct: EBI-24686270; Score: 0.56
DE  Interaction: Q9NRQ5; IntAct: EBI-23722140; Score: 0.56
DE  Interaction: Q96IW7; IntAct: EBI-23723397; Score: 0.56
DE  Interaction: Q6PI78; IntAct: EBI-24690855; Score: 0.56
DE  Interaction: Q96F15; IntAct: EBI-23780523; Score: 0.56
DE  Interaction: Q8N6R1; IntAct: EBI-23798787; Score: 0.56
DE  Interaction: O95070; IntAct: EBI-23825176; Score: 0.56
DE  Interaction: Q08426; IntAct: EBI-24755804; Score: 0.56
DE  Interaction: O95292; IntAct: EBI-24784464; Score: 0.56
DE  Interaction: Q8WWP7; IntAct: EBI-24641110; Score: 0.56
DE  Interaction: O15155; IntAct: EBI-24644551; Score: 0.56
DE  Interaction: O75379; IntAct: EBI-24799716; Score: 0.56
DE  Interaction: Q96HH6; IntAct: EBI-25213278; Score: 0.56
DE  Interaction: Q15836; IntAct: EBI-25224808; Score: 0.56
DE  Interaction: Q8WVX3; IntAct: EBI-25273998; Score: 0.56
DE  Interaction: P19739; IntAct: EBI-25685423; Score: 0.35
DE  Interaction: P0DTD8; IntAct: EBI-25687199; Score: 0.35
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0016020;
GO  GO:0005641;
GO  GO:0048471;
GO  GO:0043295;
GO  GO:0004602;
GO  GO:0004364;
GO  GO:0004667;
GO  GO:0050220;
GO  GO:0008283;
GO  GO:0008285;
GO  GO:0032308;
GO  GO:0001516;
GO  GO:0006693;
GO  GO:0031620;
GO  GO:0050727;
GO  GO:0019233;
GO  GO:0007165;
TP  Membrane Topology: Transmembrane; Source: UniProt - Curator Inference {ECO:0000305|PubMed:23431194};
SQ  MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIY
SQ  PFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
//