ID  O14976;
PN  Cyclin-G-associated kinase;
GN  GAK;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:10625686}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:10625686}. Cell junction, focal adhesion {ECO:0000305|PubMed:10625686}. Note=Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions.
DR  UNIPROT: O14976;
DR  UNIPROT: Q5U4P5;
DR  UNIPROT: Q9BVY6;
DR  PDB: 4C57;
DR  PDB: 4C58;
DR  PDB: 4C59;
DR  PDB: 4O38;
DR  PDB: 4Y8D;
DR  PDB: 5Y7Z;
DR  PDB: 5Y80;
DR  Pfam: PF00069;
DR  Pfam: PF10409;
DR  PROSITE: PS51182;
DR  PROSITE: PS50076;
DR  PROSITE: PS51181;
DR  PROSITE: PS50011;
DR  PROSITE: PS00108;
DR  OMIM: 602052;
DR  DisGeNET: 2580;
DE  Function: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. {ECO:0000269|PubMed:10625686}.
DE  Reference Proteome: Yes;
DE  Interaction: O14966; IntAct: EBI-9247728; Score: 0.35
DE  Interaction: O15169; IntAct: EBI-731365; Score: 0.00
DE  Interaction: O60763; IntAct: EBI-759358; Score: 0.37
DE  Interaction: P10275; IntAct: EBI-1632203; Score: 0.37
DE  Interaction: Q9Q2G4; IntAct: EBI-6174875; Score: 0.35
DE  Interaction: Q9NQ11; IntAct: EBI-6377262; Score: 0.51
DE  Interaction: Q5S007; IntAct: EBI-9247177; Score: 0.79
DE  Interaction: P11142; IntAct: EBI-9655962; Score: 0.69
DE  Interaction: Q9UL15; IntAct: EBI-9655962; Score: 0.35
DE  Interaction: Q38SD2; IntAct: EBI-9659083; Score: 0.44
DE  Interaction: Q76MZ3; IntAct: EBI-10991736; Score: 0.35
DE  Interaction: A2AUM9; IntAct: EBI-10994361; Score: 0.35
DE  Interaction: P63005; IntAct: EBI-11041417; Score: 0.35
DE  Interaction: P10126; IntAct: EBI-11048962; Score: 0.35
DE  Interaction: G3X972; IntAct: EBI-11079358; Score: 0.35
DE  Interaction: P09497; IntAct: EBI-11081190; Score: 0.35
DE  Interaction: Q9NYZ3; IntAct: EBI-11081743; Score: 0.35
DE  Interaction: Q13492; IntAct: EBI-11082344; Score: 0.35
DE  Interaction: Q00610; IntAct: EBI-11082478; Score: 0.35
DE  Interaction: O15027; IntAct: EBI-11083608; Score: 0.35
DE  Interaction: Q9Z1Z0; IntAct: EBI-11112182; Score: 0.35
DE  Interaction: P15735; IntAct: EBI-11135895; Score: 0.35
DE  Interaction: P51805; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q07912; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q96CW1; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q9H2Y7; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q5TB80; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q8TEH3; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q8N684; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q9Y496; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q14789; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q2M2I8; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q8N556; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: O43175; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: O75146; IntAct: EBI-11150908; Score: 0.53
DE  Interaction: P47756; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: P27482; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: P53992; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q14677; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q9UHB6; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: P49757; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q9ULH0; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: P42566; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: P55735; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q13813; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q96PK6; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: E9PK67; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q96FJ0; IntAct: EBI-11150908; Score: 0.53
DE  Interaction: Q8IVT2; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: P53675; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: P09496; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: P08047; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q9H0K6; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q8WXE9; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q27J81; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: P14384; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: P28066; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q3B7T1; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q6ZRV2; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q9UBH6; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: O00159; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q16643; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q5T0W9; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: O00443; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: H0YEF7; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q9NSY1; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: F5GWT4; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q9UM54; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q8N3V7; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: P62158; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q9UK73; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: P63010; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: O94973; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q13470; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q8TDG2; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: O00291; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: O95782; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: Q9BY43; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: P98082; IntAct: EBI-11150908; Score: 0.35
DE  Interaction: P29703; IntAct: EBI-11525188; Score: 0.56
DE  Interaction: P56945; IntAct: EBI-15099463; Score: 0.35
DE  Interaction: Q8IWL3; IntAct: EBI-13943458; Score: 0.35
DE  Interaction: Q6IQ23; IntAct: EBI-16398399; Score: 0.35
DE  Interaction: Q8TBP5; IntAct: EBI-21502646; Score: 0.35
DE  Interaction: Q9P296; IntAct: EBI-21519943; Score: 0.35
DE  Interaction: Q8N3R9; IntAct: EBI-21627185; Score: 0.35
DE  Interaction: Q9UJ41; IntAct: EBI-21644136; Score: 0.35
DE  Interaction: O95630; IntAct: EBI-21667922; Score: 0.35
DE  Interaction: Q9NZL4; IntAct: EBI-21711136; Score: 0.35
DE  Interaction: Q09019; IntAct: EBI-21714883; Score: 0.35
DE  Interaction: Q9ULV8; IntAct: EBI-21715242; Score: 0.35
DE  Interaction: Q8N2M8; IntAct: EBI-21714908; Score: 0.35
DE  Interaction: Q96SL4; IntAct: EBI-21714987; Score: 0.35
DE  Interaction: Q9NSE4; IntAct: EBI-21715157; Score: 0.35
DE  Interaction: Q01968; IntAct: EBI-16412116; Score: 0.35
DE  Interaction: Q9Y6W8; IntAct: EBI-16721689; Score: 0.35
DE  Interaction: O43493; IntAct: EBI-16800265; Score: 0.27
DE  Interaction: Q9Y4C4; IntAct: EBI-20590176; Score: 0.44
DE  Interaction: Q9Y586; IntAct: EBI-21261050; Score: 0.35
DE  Interaction: P49023; IntAct: EBI-25376663; Score: 0.35
DE  Interaction: Q9C0B5; IntAct: EBI-25637382; Score: 0.35
DE  Interaction: P51617; IntAct: EBI-28935882; Score: 0.35
DE  Interaction: Q9BYP7; IntAct: EBI-28946054; Score: 0.35
DE  Interaction: P31947; IntAct: EBI-30814567; Score: 0.44
DE  Interaction: P04637; IntAct: EBI-34581131; Score: 0.35
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005925;
GO  GO:0005794;
GO  GO:0043231;
GO  GO:0016020;
GO  GO:0048471;
GO  GO:0098793;
GO  GO:0031982;
GO  GO:0005524;
GO  GO:0051087;
GO  GO:0030276;
GO  GO:0030332;
GO  GO:0106310;
GO  GO:0004674;
GO  GO:0007049;
GO  GO:0051085;
GO  GO:0072318;
GO  GO:1905224;
GO  GO:0072583;
GO  GO:0007029;
GO  GO:0007030;
GO  GO:0090160;
GO  GO:0010977;
GO  GO:0034067;
GO  GO:0072659;
GO  GO:0006468;
GO  GO:0006898;
GO  GO:0016191;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNR
SQ  AIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQ
SQ  HMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPI
SQ  GEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAAR
SQ  NVNPKSPITELLEQNGGYGSATLSRGPPPPVGPAGSGYSGGLALAEYDQPYGGFLDILRGGTERLFTNLKDTSSKVIQSV
SQ  ANYAKGDLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRTYRPSRFHNRVSECGWAARRAP
SQ  HLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFSMKRCPPGIWPSHKRYIEYMC
SQ  DMVAEEPITPHSKPILVRAVVMTPVPLFSKQRSGCRPFCEVYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGDV
SQ  LIVIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRPSREAP
SQ  PWENSSMRGLNPKILFSSREEQQDILSKFGKPELPRQPGSTAQYDAGAGSPEAEPTDSDSPPSSSADASRFLHTLDWQEE
SQ  KEAETGAENASSKESESALMEDRDESEVSDEGGSPISSEGQEPRADPEPPGLAAGLVQQDLVFEVETPAVLPEPVPQEDG
SQ  VDLLGLHSEVGAGPAVPPQACKAPSSNTDLLSCLLGPPEAASQGPPEDLLSEDPLLLASPAPPLSVQSTPRGGPPAAADP
SQ  FGPLLPSSGNNSQPCSNPDLFGEFLNSDSVTVPPSFPSAHSAPPPSCSADFLHLGDLPGEPSKMTASSSNPDLLGGWAAW
SQ  TETAASAVAPTPATEGPLFSPGGQPAPCGSQASWTKSQNPDPFADLGDLSSGLQGSPAGFPPGGFIPKTATTPKGSSSWQ
SQ  TSRPPAQGASWPPQAKPPPKACTQPRPNYASNFSVIGAREERGVRAPSFAQKPKVSENDFEDLLSNQGFSSRSDKKGPKT
SQ  IAEMRKQDLAKDTDPLKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVGMADLVAPEQVKKHYRRAVLAVHPDKAA
SQ  GQPYEQHAKMIFMELNDAWSEFENQGSRPLF
//