ID  O15504;
PN  Nucleoporin NUP42;
GN  NUP42;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus, nuclear pore complex {ECO:0000269|PubMed:12228227, ECO:0000269|PubMed:16000379}. Nucleus membrane {ECO:0000269|PubMed:12228227, ECO:0000269|PubMed:16000379}; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:12228227}. Note=Excluded from the nucleolus. {ECO:0000269|PubMed:10358091}.
DR  UNIPROT: O15504;
DR  UNIPROT: A4D143;
DR  UNIPROT: B4DP42;
DR  UNIPROT: Q49AE7;
DR  UNIPROT: Q9BS49;
DR  PDB: 6B4F;
DR  PDB: 6B4I;
DR  PDB: 6B4J;
DR  PROSITE: PS50103;
DR  DisGeNET: 11097;
DE  Function: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. {ECO:0000269|PubMed:10610322, ECO:0000269|PubMed:16000379}. (Microbial infection) In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope. {ECO:0000269|PubMed:12228227}.
DE  Reference Proteome: Yes;
DE  Interaction: Q03518; IntAct: EBI-8550622; Score: 0.37
DE  Interaction: P24386; IntAct: EBI-2515120; Score: 0.40
DE  Interaction: A0A6L8P1I1; IntAct: EBI-2828503; Score: 0.00
DE  Interaction: Q81KT8; IntAct: EBI-2828510; Score: 0.00
DE  Interaction: Q9H0R8; IntAct: EBI-3623653; Score: 0.35
DE  Interaction: P25054; IntAct: EBI-3437356; Score: 0.00
DE  Interaction: Q92905; IntAct: EBI-21325777; Score: 0.35
DE  Interaction: Q6PFD9; IntAct: EBI-10994876; Score: 0.35
DE  Interaction: Q8BH74; IntAct: EBI-10997196; Score: 0.35
DE  Interaction: Q9ERU9; IntAct: EBI-10999306; Score: 0.35
DE  Interaction: Q7KZI7; IntAct: EBI-11002856; Score: 0.35
DE  Interaction: A5YKK6; IntAct: EBI-11005861; Score: 0.35
DE  Interaction: P63280; IntAct: EBI-11044140; Score: 0.35
DE  Interaction: Q09161; IntAct: EBI-11060556; Score: 0.35
DE  Interaction: P49790; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: Q9BVL2; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: Q14974; IntAct: EBI-11115566; Score: 0.35
DE  Interaction: P57740; IntAct: EBI-11160436; Score: 0.35
DE  Interaction: P55735; IntAct: EBI-11888324; Score: 0.37
DE  Interaction: O76011; IntAct: EBI-24510043; Score: 0.56
DE  Interaction: E5LBS6; IntAct: EBI-14062727; Score: 0.35
DE  Interaction: Q9GZY0; IntAct: EBI-21528397; Score: 0.35
DE  Interaction: Q8N4J0; IntAct: EBI-21736494; Score: 0.35
DE  Interaction: Q13158; IntAct: EBI-20736966; Score: 0.35
DE  Interaction: Q8IW93; IntAct: EBI-25410221; Score: 0.35
GO  GO:0005829;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0046872;
GO  GO:0005049;
GO  GO:0003723;
GO  GO:0051028;
GO  GO:0006913;
GO  GO:0006611;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MAICQFFLQGRCRFGDRCWNEHPGARGAGGGRQQPQQQPSGNNRRGWNTTSQRYSNVIQPSSFSKSTPWGGSRDQEKPYF
SQ  SSFDSGASTNRKEGFGLSENPFASLSPDEQKDEKKLLEGIVKDMEVWESSGQWMFSVYSPVKKKPNISGFTDISPEELRL
SQ  EYHNFLTSNNLQSYLNSVQRLINQWRNRVNELKSLNISTKVALLSDVKDGVNQAAPAFGFGSSQAATFMSPGFPVNNSSS
SQ  DNAQNFSFKTNSGFAAASSGSPAGFGSSPAFGAAASTSSGISTSAPAFGFGKPEVTSAASFSFKSPAASSFGSPGFSGLP
SQ  ASLATGPVRAPVAPAFGGGSSVAGFGSPGSHSHTAFSKPSSDTFGNSSISTSLSASSSIIATDNVLFTPRDKLTVEELEQ
SQ  FQSKKFTLGKIPLKPPPLELLNV
//