ID  O18998;
PN  Deoxyribonuclease-1;
GN  DNASE1;
OS  9986;
SL  Nucleus Position: SL-0178;
SL  Comments: Secreted {ECO:0000250|UniProtKB:P24855}. Zymogen granule {ECO:0000250|UniProtKB:P24855}. Nucleus envelope {ECO:0000250|UniProtKB:P24855}. Note=Secretory protein, stored in zymogen granules and found in the nuclear envelope. {ECO:0000250|UniProtKB:P24855}.
DR  UNIPROT: O18998;
DR  Pfam: PF03372;
DR  PROSITE: PS00919;
DE  Function: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:9230129). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (PubMed:9230129). Preferentially attacks double-stranded DNA and produces oligonucleotides with 5'-phospho and 3'-hydroxy termini (PubMed:9230129). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity). {ECO:0000250|UniProtKB:P21704, ECO:0000250|UniProtKB:P49183, ECO:0000269|PubMed:9230129}.
DE  Reference Proteome: Yes;
GO  GO:0005576;
GO  GO:0005635;
GO  GO:0042588;
GO  GO:0003779;
GO  GO:0004530;
GO  GO:0006915;
GO  GO:0000737;
GO  GO:0002283;
GO  GO:0002673;
GO  GO:0070948;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MRSEMLTALLTLAVLLQVAGSLKIAAFNIRSFGETKMSNATLTSYIVRILQRYDIALIQEVRDSHLTAVGKLLDKLNEKA
SQ  ADTYRFVASEPLGRRTYKERYLFVYRPDQVSVLDSYYYDDGCEPCGTDTFSREPAVVRFSSPSTKVREFAIVPLHSAPED
SQ  AVAEIDALYDVYLDVQKKWGLQDVMLMGDFNADYSYVTSSQWSSIRLRTNPAFKWLIPDTADTTATSTNCAYDRIVVAGP
SQ  LLQDAVVPNSAAPFNFQAAYGLSNQLAQAISDHYPVEVTLA
//