ID  O35413;
PN  Sorbin and SH3 domain-containing protein 2;
GN  Sorbs2;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:10521485, ECO:0000269|PubMed:15128873, ECO:0000269|PubMed:15659545, ECO:0000269|PubMed:16125169}. Apical cell membrane {ECO:0000250|UniProtKB:O94875}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:O94875}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O94875}. Note=Detected in the stress fibers, synaptosomal cytosol, postsynaptic density fraction, Z-disks and intercalated. The CBL/PTK2B/ARGBP2 complex is recruited to lipid rafts following growth factor stimulation. In pancreatic acinar cells, localized preferentially to the apical membrane. Colocalized with vinculin and filamentous actin at focal adhesions and lamellipodia of pancreatic cells. {ECO:0000250|UniProtKB:O94875}.
DR  UNIPROT: O35413;
DR  UNIPROT: Q923T8;
DR  Pfam: PF00018;
DR  Pfam: PF14604;
DR  Pfam: PF02208;
DR  PROSITE: PS50002;
DR  PROSITE: PS50831;
DE  Function: Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 (By similarity). May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (By similarity). Isoform 2 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000250, ECO:0000250|UniProtKB:O94875, ECO:0000269|PubMed:10521485}.
DE  Reference Proteome: Yes;
DE  Interaction: Q62910; IntAct: EBI-7458056; Score: 0.40
DE  Interaction: P16086; IntAct: EBI-7458130; Score: 0.40
DE  Interaction: P21575; IntAct: EBI-7458357; Score: 0.59
DE  Interaction: P39052; IntAct: EBI-7458445; Score: 0.40
DE  Interaction: Q9WVJ4; IntAct: EBI-7458481; Score: 0.40
DE  Interaction: Q5FWU0; IntAct: EBI-7458532; Score: 0.40
DE  Interaction: P49286; IntAct: EBI-11578506; Score: 0.00
DE  Interaction: Q5XIE8; IntAct: EBI-26439741; Score: 0.35
GO  GO:0016324;
GO  GO:0030425;
GO  GO:0005925;
GO  GO:0030027;
GO  GO:0043025;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0014069;
GO  GO:0045202;
GO  GO:0019904;
GO  GO:0095500;
GO  GO:0007015;
GO  GO:0061049;
GO  GO:0007219;
GO  GO:1904393;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MNTDSGGCARKRAAMSVTLTSVKRVQSSPNLLAAGRESHSPDSAWRSYNGRNPETLNGDATYSSLAAKGFRSVRPNLQDK
SQ  KSPTQSHITINGNSGGAVSPVSYYQRPFSPSAYSLPASLNSSIIMPHGRSLDSAETYSQHAQSLDGTMGSSIPLYRSSEE
SQ  EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDEDTDMYNTPYTYNAGLYNSPYSAQSHPA
SQ  AKTQTYRPLSKSHSDNGTDAFKEATSPVPPPHVPPRPRDQSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH
SQ  ERPVSVYQSSIDRSLERPSSSASMAGDFRKRRKSEPAVGPPRGLGDHSSSRTSPGRADLPGSSSTFTTSFISSSPSSPSR
SQ  AQGGDDSKMCPPLCSYSGLNGSPSSELECCGAYRRHLDVPQDSQRAITFKNGWQMARQNAEIWSSTEEAVSPKIKSRSCD
SQ  DLLNDDCGSFPDPKTKSESMGSLLCDEGSKESDPMTWTSPYIPEVCGNSRSRLKHRSAHNAPGFLKMYKKMHRINRKDLM
SQ  NSEVICSVKSRILQYEKEQQHRGLLHGWSQSSTEEVPRDVVPTRISEFEKLIQKSKSMPNLGDEMLSPVTLEPPQNGLCP
SQ  KRRFSIESLLEEETQVRHPSQGQRSCKSNTLVPIHIEVTSDEQPRTHMEFSDSDQDGVVSDHSDNVHVERSSFCSESDFD
SQ  HFSFTSSESFYGSSHHHHHHHHHHGHFISSCKGRCPASYTRFTTMLKHERAKHENIDRPRRQDMDPGLSKLAFLVSPVPF
SQ  RRKKVLTPQKQTEQAKCKASVVEALDSALKDICDQIKAEKRRGSLPDNSILHRLISELLPQIPKRNSSLNALKRSPMHQP
SQ  FHPLPQDGAIHCPLYQNDCGRMPHSASFPDVDTTSSYHAQDYGSVLSLQDHESPRSYSSTLTDLGRSVSRERRGTPEKEV
SQ  KLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPVQPGEIGEAI
SQ  AKYNFNADTNVELSLRKGDRIILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKRNTKGSEDYPDPPLPHSYSSDRIYSL
SQ  SSNKPQRPVFSHENIQGGGEPFQALYNYTPRNEDELELRESDVVDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
//