ID  O35430;
PN  Amyloid-beta A4 precursor protein-binding family A member 1;
GN  Apba1;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20531236}. Note=Only a small proportion of the protein is nuclear. [Isoform 2]: Golgi apparatus {ECO:0000250}.
DR  UNIPROT: O35430;
DR  PDB: 4DBB;
DR  PDB: 6KMH;
DR  Pfam: PF00595;
DR  Pfam: PF00640;
DR  PROSITE: PS50106;
DR  PROSITE: PS01179;
DE  Function: Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.
DE  Reference Proteome: Yes;
DE  Interaction: P26010; IntAct: EBI-8611689; Score: 0.44
DE  Interaction: P05106; IntAct: EBI-8611732; Score: 0.44
DE  Interaction: P05556; IntAct: EBI-8611776; Score: 0.44
DE  Interaction: Q99PW8; IntAct: EBI-7293493; Score: 0.64
DE  Interaction: Q00975; IntAct: EBI-7076778; Score: 0.51
DE  Interaction: Q02294; IntAct: EBI-7076897; Score: 0.40
DE  Interaction: Q62889; IntAct: EBI-7414748; Score: 0.44
DE  Interaction: Q63373; IntAct: EBI-7414873; Score: 0.27
DE  Interaction: P49768; IntAct: EBI-8513481; Score: 0.40
DE  Interaction: P05067; IntAct: EBI-8513444; Score: 0.52
DE  Interaction: P52188; IntAct: EBI-704679; Score: 0.35
DE  Interaction: P32851; IntAct: EBI-8545713; Score: 0.66
DE  Interaction: P61765; IntAct: EBI-2027999; Score: 0.62
DE  Interaction: Q24008; IntAct: EBI-4307047; Score: 0.56
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0043197;
GO  GO:0098978;
GO  GO:0005794;
GO  GO:0016020;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0048787;
GO  GO:0032991;
GO  GO:0098685;
GO  GO:0008021;
GO  GO:0001540;
GO  GO:0030165;
GO  GO:0005546;
GO  GO:0044877;
GO  GO:0007268;
GO  GO:0051649;
GO  GO:0014051;
GO  GO:0014047;
GO  GO:0001701;
GO  GO:0006886;
GO  GO:0007626;
GO  GO:0035264;
GO  GO:0065003;
GO  GO:0010468;
GO  GO:2000300;
GO  GO:0016079;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MNHLEGSAEVEVADEAPGGEVNESVEADLEHPEVEEEQQPSPPPPAGHAPEDHRAHPAPPPPPPPQEEEEERGECLARSA
SQ  STESGFHNHTDTAEGDVLAAARDGYEAERAQDADDESAYAVQYRPEAEEYTEQAEAEHAEAAQRRALPNHLHFHSLEHEE
SQ  AMNAAYSGYVYTHRLFHRAEDEPYAEPYADYGGLQEHVYEEIGDAPELEARDGLRLYERERDEAAAYRQEALGARLHHYD
SQ  ERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERAPTPGGGHPDSPGLPAP
SQ  AGQQQRVVGTPGGSEVGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPVD
SQ  GDSPSPGSSSPLGAESSITPLHPGDPTEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPS
SQ  KNVRMMQAQEAVSRIKTAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQEPMMDHPLRTISYIADIGNIVVLM
SQ  ARRRMPRSNSQENVEASHPSQDAKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQ
SQ  DMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLP
SQ  LSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVA
SQ  TPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI
//