ID  O35710;
PN  Nocturnin;
GN  Noct;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:23449310}. Nucleus {ECO:0000269|PubMed:23449310}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:20498072}. Mitochondrion {ECO:0000250|UniProtKB:Q9UK39}.
DR  UNIPROT: O35710;
DR  UNIPROT: Q9QZG9;
DR  Pfam: PF03372;
DE  Function: Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (By similarity). Shows a small preference for NADPH over NADP(+) (By similarity). Represses translation and promotes degradation of target mRNA molecules (By similarity). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (PubMed:20685873, PubMed:20498072). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (PubMed:20498072, PubMed:22082366, PubMed:21820310, PubMed:22073225, PubMed:22331129). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (PubMed:20498072, PubMed:22082366). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (PubMed:20498072). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (PubMed:22073225, PubMed:20685873). Critical for proper development of early embryos (PubMed:23449310). {ECO:0000250|UniProtKB:Q9UK39, ECO:0000269|PubMed:20498072, ECO:0000269|PubMed:20685873, ECO:0000269|PubMed:21820310, ECO:0000269|PubMed:22073225, ECO:0000269|PubMed:22082366, ECO:0000269|PubMed:22331129, ECO:0000269|PubMed:23449310}.
DE  Reference Proteome: Yes;
DE  Interaction: P37238; IntAct: EBI-15856114; Score: 0.40
GO  GO:0005737;
GO  GO:0005739;
GO  GO:0005634;
GO  GO:0000932;
GO  GO:0048471;
GO  GO:0000175;
GO  GO:0046872;
GO  GO:0003729;
GO  GO:0019178;
GO  GO:0102757;
GO  GO:0004535;
GO  GO:0032922;
GO  GO:0007623;
GO  GO:0000290;
GO  GO:0048255;
GO  GO:0006739;
GO  GO:0010629;
GO  GO:0045668;
GO  GO:0033962;
GO  GO:0045600;
GO  GO:0042752;
GO  GO:0045995;
GO  GO:0009991;
GO  GO:0032496;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MYQSPRRLCSALLLRDAPGLRRTLVPGPRRTLAPPVLGSRPKSPQLQAAAASGAARSRPRTVSSMGNGTSRLYSALAKTV
SQ  NSSAAAQHPEYLVSTDPEHLEPIDPKELLEECRAVLHTRPPRYQRDFVDLRTDCSSSHSPIRVMQWNILAQALGEGKDNF
SQ  VQCPVEALKWEERKCLILEEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQ
SQ  NRFKLISSTNIRLTAMTLKTNQVAIAQTLECKESGRQFCIAVTHLKARTGWERFRSAQGCDLLQNLQNITQGAKIPLIVC
SQ  GDFNAEPTEEVYKHFASSSLNLNSAYKLLSPDGQSEPPYTTWKIRTSGECRHTLDYIWYSRHALSVTSALDLLTEEQIGP
SQ  NRLPSFHYPSDHLSLVCDFSFNEEPHELF
//