ID  O44749;
PN  Protein pid-4;
GN  pid;
OS  6239;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:33231880}. Cytoplasm, P-body {ECO:0000269|PubMed:33231880}. Note=Co-localizes with pid-5 at P granules in germ cells. {ECO:0000269|PubMed:33231880}.
DR  UNIPROT: O44749;
DE  Function: Together with pid-5, it is involved in gene silencing mediated by a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and guide the Piwi protein prg-1 to its DNA targets for silencing (PubMed:33231880). Together with pid-5, it is required for the biogenesis of secondary and tertiary 22G-siRNAs (PubMed:33231880). Specifically, promotes the production of 22G-siRNAs from the 5' end of target mRNAs (PubMed:33231880). Together with pid-5, plays a role in small RNA-directed transgenerational epigenetic inheritance (also called RNAe) over several generations and germline immortality (PubMed:33231880). Together with pid-5, plays a role in the formation of liquid-like condensates in the cytoplasm called Z granules (PubMed:33231880). {ECO:0000269|PubMed:33231880}.
DE  Reference Proteome: Yes;
DE  Interaction: Q20655; IntAct: EBI-2418054; Score: 0.49
DE  Interaction: P41932; IntAct: EBI-2419419; Score: 0.49
DE  Interaction: Q17604; IntAct: EBI-16012007; Score: 0.35
GO  GO:0000932;
GO  GO:0048471;
GO  GO:0031047;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MNTHNARDSDDESPLESEEHLKRFFAGRNLYSQTKIDDARKKSHDAKYAKEVEWDAKDTAKGKPVFKKYRQEIADKTSRC
SQ  DAQFINNLHTYYGNGSELRELPETHYAVDFMGTTIATTEMTAELKKLKVLKKKTATSQFVREHRQLGFIPTPSRRSLSCT
SQ  GRFMNFETKCDERPDRTNPEFSVGNNNFLSATISNLDEDFKTPSNCEHVASIVPKEISNALTALIPHVNVFDYEKGEMEI
SQ  GKVLCSNKNLHAYVIPKQHDQEQMLKDFSARFLAWYNKLSHLQRDTFGTDKDPKRSGKQEDGKPMKPYFWRVNVILCLQE
SQ  FQEEGTMFRRARHVCGIRPHKSQPGLDLYIEIDTGSMRALKTNYLTVRKLPQEFANVPTPILEVRFEGAKTEEDVARRIA
SQ  HIRKTGRAYIKSFDTGKRKIYQNSFFNGQPKDWSNIETAVLLPPKESSMSKLFCEDRDCMGLCCTDQWLENAESSPGIST
SQ  IPASWIADKNKKPFVDRSPQKFKFPASGSYMKPAN
//