ID  O55047;
PN  Serine/threonine-protein kinase tousled-like 2;
GN  Tlk2;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Nucleus {ECO:0000269|PubMed:10455159}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10455159}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10455159}. Note=Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2.
DR  UNIPROT: O55047;
DR  UNIPROT: B1ASU7;
DR  UNIPROT: B1ASU8;
DR  UNIPROT: Q9D5Y5;
DR  Pfam: PF00069;
DR  PROSITE: PS00107;
DR  PROSITE: PS50011;
DR  PROSITE: PS00108;
DE  Function: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A and ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (By similarity). Negative regulator of amino acid starvation-induced autophagy (By similarity). {ECO:0000250}. Testis-specific isoforms may play a role in spermatogenesis. Highly expressed in embryos throughout development. {ECO:0000269|PubMed:10092119}.
DE  Reference Proteome: Yes;
DE  Interaction: P83510; IntAct: EBI-16734044; Score: 0.35
GO  GO:0005882;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005524;
GO  GO:0042802;
GO  GO:0106310;
GO  GO:0004674;
GO  GO:0007049;
GO  GO:0030154;
GO  GO:0006974;
GO  GO:0071480;
GO  GO:0006325;
GO  GO:0007059;
GO  GO:0035556;
GO  GO:0032435;
GO  GO:0018105;
GO  GO:0006468;
GO  GO:1902275;
GO  GO:0007283;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYDTSQGKGTPR
SQ  GHKISDYFERRAEQPLYGLDGSAAKEASEEQSALPTLMSVMLAKPRLDTEQLAPRGAGLCFTFVSAQQNSPSSTGSGNTE
SQ  HSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKK
SQ  LLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQ
SQ  APPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKD
SQ  HPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS
SQ  LDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDF
SQ  GLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQEN
SQ  TILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN
//