ID  O57429;
PN  Ubiquitin carboxyl-terminal hydrolase 2;
GN  USP2;
OS  9031;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250|UniProtKB:O88623}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O88623}.
DR  UNIPROT: O57429;
DR  Pfam: PF00443;
DR  PROSITE: PS00972;
DR  PROSITE: PS00973;
DR  PROSITE: PS50235;
DE  Function: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Possesses both ubiquitin- specific peptidase and isopeptidase activities. May play a role in the regulation of the circadian clock. {ECO:0000250|UniProtKB:O75604, ECO:0000250|UniProtKB:O88623}.
DE  Reference Proteome: Yes;
GO  GO:0005737;
GO  GO:0048471;
GO  GO:0004843;
GO  GO:0046872;
GO  GO:0016579;
GO  GO:0048511;
GO  GO:0006511;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAARMAPTPRSSKVVQGLTGLRNLGNTCFMNSILQCLSNTKELRDYCLQNQYLRDLNNNSRMRTALMSEFAKLIQLLWTS
SQ  SPNDSVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHGEVNRVLVRPRANADTLDHLPDDEKSRQMWRRYQERED
SQ  SRVSDLFVGQLKSSLTCSECGYCSTAFDPFWDLSLPIPKKGYGEVTLMDCLRLFTKEDVLDGDEKPTCCRCKARTRCTKK
SQ  FSIQKFPKILVLHLKRFSEARIRASKLTTFVNFPLKDLDLREFASQSCNHAVYNLYAVSNHSGTTMGGHYTAYCKSPISS
SQ  EWHSFNDSRVTPMSSSHVRSSDAYLLFYELASPSSRM
//