ID  O60271;
PN  C-Jun-amino-terminal kinase-interacting protein 4;
GN  SPAG9;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250|UniProtKB:Q58A65}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q58A65}. Lysosome membrane {ECO:0000269|PubMed:29146937}. Note=Perinuclear distribution in response to stress signals such as UV radiation. {ECO:0000250|UniProtKB:Q58A65}. [Isoform 5]: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:15693750}. Note=Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix. {ECO:0000269|PubMed:15693750}.
DR  UNIPROT: O60271;
DR  UNIPROT: A6H8U5;
DR  UNIPROT: A8MSX0;
DR  UNIPROT: B4DHH2;
DR  UNIPROT: O60905;
DR  UNIPROT: Q3KQU8;
DR  UNIPROT: Q3MKM7;
DR  UNIPROT: Q86WC7;
DR  UNIPROT: Q86WC8;
DR  UNIPROT: Q8IZX7;
DR  UNIPROT: Q96II0;
DR  UNIPROT: Q9H811;
DR  PDB: 2W83;
DR  Pfam: PF16471;
DR  Pfam: PF09744;
DR  PROSITE: PS51776;
DR  PROSITE: PS51777;
DR  OMIM: 605430;
DR  DisGeNET: 9043;
DE  Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein- dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}.
DE  Reference Proteome: Yes;
DE  Interaction: P19838; IntAct: EBI-353534; Score: 0.69
DE  Interaction: O88447; IntAct: EBI-7681059; Score: 0.27
DE  Interaction: Q14240; IntAct: EBI-1068469; Score: 0.00
DE  Interaction: P53350; IntAct: EBI-2372594; Score: 0.73
DE  Interaction: Q07832; IntAct: EBI-2560950; Score: 0.40
DE  Interaction: Q8ZED8; IntAct: EBI-2866304; Score: 0.00
DE  Interaction: P62330; IntAct: EBI-7140974; Score: 0.62
DE  Interaction: O60271; IntAct: EBI-7141074; Score: 0.44
DE  Interaction: P84077; IntAct: EBI-7141242; Score: 0.44
DE  Interaction: Q9HC52; IntAct: EBI-3951861; Score: 0.35
DE  Interaction: Q9GZQ8; IntAct: EBI-7190550; Score: 0.37
DE  Interaction: Q9NPJ4; IntAct: EBI-7316035; Score: 0.37
DE  Interaction: P62331; IntAct: EBI-7832567; Score: 0.40
DE  Interaction: Q96A65; IntAct: EBI-9817790; Score: 0.56
DE  Interaction: P23771; IntAct: EBI-10891010; Score: 0.35
DE  Interaction: A3KN83; IntAct: EBI-11898766; Score: 0.00
DE  Interaction: Q9UQ88; IntAct: EBI-11901851; Score: 0.00
DE  Interaction: Q9UKN8; IntAct: EBI-11901842; Score: 0.00
DE  Interaction: Q9UBC2; IntAct: EBI-11901833; Score: 0.00
DE  Interaction: Q8WUA4; IntAct: EBI-11901824; Score: 0.00
DE  Interaction: P11274; IntAct: EBI-11901815; Score: 0.00
DE  Interaction: P30291; IntAct: EBI-11907279; Score: 0.00
DE  Interaction: P33991; IntAct: EBI-11907576; Score: 0.00
DE  Interaction: P33993; IntAct: EBI-11907675; Score: 0.00
DE  Interaction: P49736; IntAct: EBI-11908484; Score: 0.00
DE  Interaction: Q00613; IntAct: EBI-11911387; Score: 0.00
DE  Interaction: Q06945; IntAct: EBI-11911777; Score: 0.00
DE  Interaction: Q12955; IntAct: EBI-11912325; Score: 0.00
DE  Interaction: Q14566; IntAct: EBI-11913337; Score: 0.00
DE  Interaction: Q14C86; IntAct: EBI-11913870; Score: 0.00
DE  Interaction: Q14683; IntAct: EBI-11913616; Score: 0.00
DE  Interaction: Q6IN85; IntAct: EBI-11917442; Score: 0.00
DE  Interaction: Q96BY7; IntAct: EBI-11926258; Score: 0.00
DE  Interaction: Q9NY27; IntAct: EBI-11934518; Score: 0.00
DE  Interaction: Q9P260; IntAct: EBI-11935551; Score: 0.00
DE  Interaction: Q9UQE7; IntAct: EBI-11939891; Score: 0.00
DE  Interaction: Q9Y4E8; IntAct: EBI-11941617; Score: 0.00
DE  Interaction: Q9Y6Y0; IntAct: EBI-11942633; Score: 0.00
DE  Interaction: Q8TBP5; IntAct: EBI-21502646; Score: 0.35
DE  Interaction: Q8N6T3; IntAct: EBI-21541414; Score: 0.35
DE  Interaction: Q9UF02; IntAct: EBI-21554221; Score: 0.35
DE  Interaction: Q86VU5; IntAct: EBI-21596714; Score: 0.35
DE  Interaction: Q6EMK4; IntAct: EBI-21651359; Score: 0.35
DE  Interaction: P08247; IntAct: EBI-21652717; Score: 0.35
DE  Interaction: Q2TBA0; IntAct: EBI-21658220; Score: 0.35
DE  Interaction: Q96MC5; IntAct: EBI-21663233; Score: 0.35
DE  Interaction: Q9UPT6; IntAct: EBI-21663692; Score: 0.35
DE  Interaction: O96006; IntAct: EBI-21692488; Score: 0.35
DE  Interaction: A6NED2; IntAct: EBI-21716445; Score: 0.35
DE  Interaction: P31350; IntAct: EBI-21732275; Score: 0.35
DE  Interaction: Q7LG56; IntAct: EBI-21732528; Score: 0.35
DE  Interaction: Q8WYK0; IntAct: EBI-21732608; Score: 0.35
DE  Interaction: O00592; IntAct: EBI-21750748; Score: 0.35
DE  Interaction: Q96CA5; IntAct: EBI-21754959; Score: 0.35
DE  Interaction: O14863; IntAct: EBI-21768088; Score: 0.35
DE  Interaction: O95159; IntAct: EBI-21768155; Score: 0.35
DE  Interaction: P06753; IntAct: EBI-21768209; Score: 0.35
DE  Interaction: P09493; IntAct: EBI-21768262; Score: 0.35
DE  Interaction: P16150; IntAct: EBI-21768371; Score: 0.35
DE  Interaction: Q14108; IntAct: EBI-21768396; Score: 0.35
DE  Interaction: Q147U7; IntAct: EBI-21768421; Score: 0.35
DE  Interaction: Q2T9K0; IntAct: EBI-21768445; Score: 0.35
DE  Interaction: Q5XKK7; IntAct: EBI-21768464; Score: 0.35
DE  Interaction: Q8N565; IntAct: EBI-21768514; Score: 0.35
DE  Interaction: Q96L93; IntAct: EBI-21768545; Score: 0.35
DE  Interaction: Q9BWT6; IntAct: EBI-21768576; Score: 0.35
DE  Interaction: Q9NWA0; IntAct: EBI-21768607; Score: 0.35
DE  Interaction: Q9NPJ6; IntAct: EBI-25472202; Score: 0.27
DE  Interaction: P61006; IntAct: EBI-21006330; Score: 0.62
DE  Interaction: Q5NFC5; IntAct: EBI-22299450; Score: 0.37
DE  Interaction: Q5NES6; IntAct: EBI-22299440; Score: 0.37
DE  Interaction: P61026; IntAct: EBI-25436875; Score: 0.40
DE  Interaction: H9EJ66; IntAct: EBI-25685143; Score: 0.35
DE  Interaction: P0DTC3; IntAct: EBI-25686340; Score: 0.35
DE  Interaction: Q2TAZ0; IntAct: EBI-26443127; Score: 0.35
DE  Interaction: P22612; IntAct: EBI-28934688; Score: 0.35
DE  Interaction: P36507; IntAct: EBI-28935019; Score: 0.35
DE  Interaction: P51617; IntAct: EBI-28935882; Score: 0.35
DE  Interaction: Q8TDX7; IntAct: EBI-28943744; Score: 0.35
DE  Interaction: Q92918; IntAct: EBI-28944233; Score: 0.35
DE  Interaction: Q96QS6; IntAct: EBI-28944559; Score: 0.35
DE  Interaction: Q99502; IntAct: EBI-27113432; Score: 0.35
DE  Interaction: O15297; IntAct: EBI-27113880; Score: 0.35
DE  Interaction: O14830; IntAct: EBI-27113806; Score: 0.35
DE  Interaction: Q8N3J5; IntAct: EBI-27114011; Score: 0.35
DE  Interaction: P56180; IntAct: EBI-27115406; Score: 0.35
GO  GO:0001669;
GO  GO:0034451;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0070062;
GO  GO:0005765;
GO  GO:0048471;
GO  GO:0042802;
GO  GO:0008432;
GO  GO:0019894;
GO  GO:0005078;
GO  GO:0030159;
GO  GO:0032418;
GO  GO:1903860;
GO  GO:0045665;
GO  GO:0001933;
GO  GO:0030335;
GO  GO:0045666;
GO  GO:0042147;
GO  GO:0051146;
GO  GO:0016192;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRD
SQ  DNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALH
SQ  QRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQP
SQ  RSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQ
SQ  VAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEG
SQ  ADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEA
SQ  EDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLF
SQ  SSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKED
SQ  GRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLD
SQ  TEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPG
SQ  ARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSE
SQ  VDENVPTAEEATEATEGNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVRE
SQ  EAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHL
SQ  LDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTY
SQ  QHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDK
SQ  VTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYID
SQ  FRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGNE
//