ID  O60645;
PN  Exocyst complex component 3;
GN  EXOC3;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250|UniProtKB:O54921}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O54921}. Cell projection, growth cone {ECO:0000250|UniProtKB:O54921}. Midbody {ECO:0000269|PubMed:18756269}. Golgi apparatus {ECO:0000305|PubMed:18756269}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q62825}. Note=Perinuclear in undifferentiated cells. Redistributes to growing neurites and growth cones during neuronal differentiation (By similarity). During mitosis, early recruitment to the midbody requires RALA, but not RALB, and EXOC2. In late stages of cytokinesis, localization to the midbody is RALB- dependent (PubMed:18756269). {ECO:0000250|UniProtKB:O54921, ECO:0000269|PubMed:18756269}.
DR  UNIPROT: O60645;
DR  UNIPROT: Q6P2E8;
DR  UNIPROT: Q8TEN6;
DR  UNIPROT: Q8WUW0;
DR  UNIPROT: Q96DI4;
DR  Pfam: PF06046;
DR  OMIM: 608186;
DR  DisGeNET: 11336;
DE  Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
DE  Reference Proteome: Yes;
DE  Interaction: A1L4K1; IntAct: EBI-25258050; Score: 0.56
DE  Interaction: P01106; IntAct: EBI-1074529; Score: 0.00
DE  Interaction: O88738; IntAct: EBI-1765706; Score: 0.35
DE  Interaction: Q8BHD1; IntAct: EBI-2557128; Score: 0.40
DE  Interaction: A0A2U2H1F8; IntAct: EBI-2870328; Score: 0.00
DE  Interaction: Q13573; IntAct: EBI-7950968; Score: 0.35
DE  Interaction: P40692; IntAct: EBI-2932395; Score: 0.37
DE  Interaction: O43684; IntAct: EBI-3916000; Score: 0.37
DE  Interaction: Q86VI4; IntAct: EBI-10764290; Score: 0.40
DE  Interaction: P00533; IntAct: EBI-10764491; Score: 0.40
DE  Interaction: Q8CAQ8; IntAct: EBI-11096643; Score: 0.35
DE  Interaction: Q9HBH9; IntAct: EBI-11139967; Score: 0.35
DE  Interaction: O00139; IntAct: EBI-11140263; Score: 0.35
DE  Interaction: Q9Z172; IntAct: EBI-11157923; Score: 0.35
DE  Interaction: Q86X19; IntAct: EBI-11372615; Score: 0.27
DE  Interaction: Q9NV70; IntAct: EBI-12449995; Score: 0.51
DE  Interaction: Q96KP1; IntAct: EBI-12450028; Score: 0.64
DE  Interaction: Q9UPT5; IntAct: EBI-12450043; Score: 0.51
DE  Interaction: Q13445; IntAct: EBI-12450043; Score: 0.51
DE  Interaction: Q96A65; IntAct: EBI-12450043; Score: 0.64
DE  Interaction: O00471; IntAct: EBI-12450093; Score: 0.64
DE  Interaction: Q9BZL4; IntAct: EBI-24371831; Score: 0.56
DE  Interaction: Q96IK5; IntAct: EBI-24472724; Score: 0.56
DE  Interaction: Q13049; IntAct: EBI-11902318; Score: 0.00
DE  Interaction: P11234; IntAct: EBI-11902309; Score: 0.00
DE  Interaction: O75386; IntAct: EBI-11902300; Score: 0.00
DE  Interaction: Q9Y2D4; IntAct: EBI-21672799; Score: 0.35
DE  Interaction: Q8IYI6; IntAct: EBI-21672932; Score: 0.51
DE  Interaction: Q8TAG9; IntAct: EBI-21673041; Score: 0.51
DE  Interaction: P35613; IntAct: EBI-21560440; Score: 0.35
DE  Interaction: P34741; IntAct: EBI-21628438; Score: 0.35
DE  Interaction: Q96EV8; IntAct: EBI-21651992; Score: 0.35
DE  Interaction: P27930; IntAct: EBI-21662122; Score: 0.35
DE  Interaction: Q13563; IntAct: EBI-21672799; Score: 0.35
DE  Interaction: Q9Y496; IntAct: EBI-21672799; Score: 0.35
DE  Interaction: Q9H0B6; IntAct: EBI-21672799; Score: 0.35
DE  Interaction: Q9BQD3; IntAct: EBI-21672799; Score: 0.35
DE  Interaction: Q9BQ69; IntAct: EBI-21672799; Score: 0.35
DE  Interaction: Q99666; IntAct: EBI-21672799; Score: 0.35
DE  Interaction: Q96NL6; IntAct: EBI-21672799; Score: 0.35
DE  Interaction: Q96JN2; IntAct: EBI-21672799; Score: 0.35
DE  Interaction: Q8WXW3; IntAct: EBI-21672799; Score: 0.35
DE  Interaction: Q8IY31; IntAct: EBI-21672799; Score: 0.35
DE  Interaction: Q8IWJ2; IntAct: EBI-21672799; Score: 0.35
DE  Interaction: P0DJD1; IntAct: EBI-21672799; Score: 0.35
DE  Interaction: Q2M2Z5; IntAct: EBI-21672799; Score: 0.35
DE  Interaction: Q15643; IntAct: EBI-21672799; Score: 0.35
DE  Interaction: Q07866; IntAct: EBI-21672799; Score: 0.35
DE  Interaction: Q32P51; IntAct: EBI-20938684; Score: 0.40
DE  Interaction: P12004; IntAct: EBI-21238234; Score: 0.37
DE  Interaction: Q96T52; IntAct: EBI-27050444; Score: 0.35
DE  Interaction: F1PAA9; IntAct: EBI-27079701; Score: 0.27
DE  Interaction: P18433; IntAct: EBI-27116377; Score: 0.27
DE  Interaction: Q9HD43; IntAct: EBI-27116527; Score: 0.27
GO  GO:0005829;
GO  GO:0000145;
GO  GO:0005794;
GO  GO:0030426;
GO  GO:0030496;
GO  GO:0048471;
GO  GO:0042734;
GO  GO:0030667;
GO  GO:0045296;
GO  GO:0000149;
GO  GO:0051601;
GO  GO:0006887;
GO  GO:0090148;
GO  GO:0000281;
GO  GO:0015031;
GO  GO:0006904;
GO  GO:0090522;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MKETDREAVATAVQRVAGMLQRPDQLDKVEQYRRREARKKASVEARLKAAIQSQLDGVRTGLSQLHNALNDVKDIQQSLA
SQ  DVSKDWRQSINTIESLKDVKDAVVQHSQLAAAVENLKNIFSVPEIVRETQDLIEQGALLQAHRKLMDLECSRDGLMYEQY
SQ  RMDSGNTRDMTLIHGYFGSTQGLSDELAKQLWMVLQRSLVTVRRDPTLLVSVVRIIEREEKIDRRILDRKKQTGFVPPGR
SQ  PKNWKEKMFTILERTVTTRIEGTQADTRESDKMWLVRHLEIIRKYVLDDLIVAKNLMVQCFPPHYEIFKNLLNMYHQALS
SQ  TRMQDLASEDLEANEIVSLLTWVLNTYTSTEMMRNVELAPEVDVGTLEPLLSPHVVSELLDTYMSTLTSNIIAWLRKALE
SQ  TDKKDWVKETEPEADQDGYYQTTLPAIVFQMFEQNLQVAAQISEDLKTKVLVLCLQQMNSFLSRYKDEAQLYKEEHLRNR
SQ  QHPHCYVQYMIAIINNCQTFKESIVSLKRKYLKNEVEEGVSPSQPSMDGILDAIAKEGCSGLLEEVFLDLEQHLNELMTK
SQ  KWLLGSNAVDIICVTVEDYFNDFAKIKKPYKKRMTAEAHRRVVVEYLRAVMQKRISFRSPEERKEGAEKMVREAEQLRFL
SQ  FRKLASGFGEDVDGYCDTIVAVAEVIKLTDPSLLYLEVSTLVSKYPDIRDDHIGALLAVRGDASRDMKQTIMETLEQGPA
SQ  QASPSYVPLFKDIVVPSLNVAKLLK
//