ID  O62255;
PN  m7GpppN-mRNA hydrolase dcap-2;
GN  dcap;
OS  6239;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasmic granule {ECO:0000269|PubMed:18439994}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:18439994}. Note=Localizes to perinuclear puncta in pachytene-stage germ cells (PubMed:18439994). Diffusely localized to cytoplasmic puncta in maturing oocytes (PubMed:18439994). {ECO:0000269|PubMed:18439994}.
DR  UNIPROT: O62255;
DR  UNIPROT: A0A061ACN4;
DR  UNIPROT: A0A061ADX7;
DR  UNIPROT: B3VKU3;
DR  UNIPROT: O62257;
DR  UNIPROT: Q2YS49;
DR  UNIPROT: Q2YS50;
DR  UNIPROT: Q45F95;
DR  Pfam: PF05026;
DR  Pfam: PF00293;
DR  PROSITE: PS51462;
DR  PROSITE: PS00893;
DE  Function: Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:16199859). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:16199859). RNA-decapping enzyme although it does not bind the RNA cap (PubMed:16199859). May contribute to gene regulation in multiple RNA pathways including monomethylguanosine- and trimethylguanosine-capped RNAs (PubMed:16199859). In oocytes, may play a role in the response to stress induced by heat shock, osmotic stress and anoxia (PubMed:18439994). Required for the developmental axon guidance and regrowth of PLM touch receptor neurons (PubMed:31983639). Early in embryogenesis, plays a role in ciliary shape formation in sensory neurons (PubMed:28887031). Promotes survival at high temperatures (PubMed:25061667). {ECO:0000269|PubMed:16199859, ECO:0000269|PubMed:18439994, ECO:0000269|PubMed:25061667, ECO:0000269|PubMed:28887031, ECO:0000269|PubMed:31983639}.
DE  Reference Proteome: Yes;
GO  GO:0005737;
GO  GO:0043186;
GO  GO:0000932;
GO  GO:0048471;
GO  GO:0050072;
GO  GO:0030145;
GO  GO:0003723;
GO  GO:0000290;
GO  GO:0008340;
GO  GO:0006397;
GO  GO:0002119;
GO  GO:0000184;
GO  GO:0040012;
GO  GO:0000003;
GO  GO:0009408;
GO  GO:0006979;
GO  GO:0009411;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MEISTENWCKKPKNRSIFSKNISFQKQNKSTEEPPSSVQKLLASLQQAQNKSDLSEQPSTSKPKKNEKRKKAVAQAPASA
SQ  PAPGPEEKKKQPKRASVGARMQQQAENARISQTKRPRQVSTSKGSSRNTTAPEQQNYQQQQQQYKGPRIPTDILDELEFR
SQ  FISNMVECEINDNIRVCFHLELAHWYYIDHMVEDDKISGCPNVGSRDFNFQMCQHCRVLRKYAHRADEVLAKFREYKSTV
SQ  PTYGAILVDPEMDHVVLVQSYFAKGKNWGFPKGKINQAEPPRDAAIRETFEETGFDFGIYSEKEKKFQRFINDGMVRLYL
SQ  VKNVPKDFNFQPQTRKEIRKIEWFKIDDLPTDKTDELPAYLQGNKFYMVMPFVKDIQIYVQKEKEKLRRRKAEAVQSTPS
SQ  SSIFSQLFPAQPPPPVPEDATPTRPMYKRLTSEELFSAFKNPPAGEVARPTLPDMSPAVNGLDTLAVLGICTPLKPGASL
SQ  NEFSGAPQNCPMISEEAGSPADPSAEIGFAMPMDLKQPVVTSDHPWQHHKISDSSAPPQTLESHQGWLDTQLVNTIMHSP
SQ  NHPLPPTSNSPATPTAVLGHLIGKPIQPQAILPQAATPTALGSAEKPKSSRISLSDNSAFKAISSTQKQSIPKATAAPPS
SQ  TEKTRSASLSGSSQVVGKPARNLFNSVVSPVSSGIQSIQGDGGAWEDVWFREQLAATTTAGTSISSLAASNQELAMINRE
SQ  ETPIEDPYFKQQAYQKAQKAQSLIPACSQWTNSIKLDIDYVVGPLSFWMQQFSTKSPVSGTGPQLP
//