ID  O75146;
PN  Huntingtin-interacting protein 1-related protein;
GN  HIP1R;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
DR  UNIPROT: O75146;
DR  UNIPROT: A6NHQ6;
DR  UNIPROT: Q6NXG8;
DR  UNIPROT: Q9UED9;
DR  PDB: 1R0D;
DR  Pfam: PF07651;
DR  Pfam: PF16515;
DR  Pfam: PF01608;
DR  PROSITE: PS50942;
DR  PROSITE: PS50945;
DR  OMIM: 605613;
DR  DisGeNET: 9026;
DE  Function: Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. {ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:14732715}.
DE  Reference Proteome: Yes;
DE  Interaction: O14976; IntAct: EBI-11150908; Score: 0.53
DE  Interaction: Q13573; IntAct: EBI-7950968; Score: 0.35
DE  Interaction: Q99459; IntAct: EBI-7954144; Score: 0.35
DE  Interaction: P19320; IntAct: EBI-6189915; Score: 0.35
DE  Interaction: Q62925; IntAct: EBI-9971384; Score: 0.00
DE  Interaction: Q13404; IntAct: EBI-9971384; Score: 0.00
DE  Interaction: P22314; IntAct: EBI-9971384; Score: 0.00
DE  Interaction: P61088; IntAct: EBI-9971384; Score: 0.00
DE  Interaction: P60033; IntAct: EBI-10766934; Score: 0.35
DE  Interaction: Q96H55; IntAct: EBI-11031416; Score: 0.35
DE  Interaction: P60710; IntAct: EBI-11045267; Score: 0.35
DE  Interaction: Q9ERG0; IntAct: EBI-11054044; Score: 0.35
DE  Interaction: Q9UHB6; IntAct: EBI-11058729; Score: 0.35
DE  Interaction: G3X972; IntAct: EBI-11079358; Score: 0.35
DE  Interaction: P09497; IntAct: EBI-11081190; Score: 0.35
DE  Interaction: Q9NYZ3; IntAct: EBI-11081743; Score: 0.35
DE  Interaction: Q13492; IntAct: EBI-11082344; Score: 0.35
DE  Interaction: Q00610; IntAct: EBI-11082478; Score: 0.35
DE  Interaction: Q9WTI7; IntAct: EBI-11093786; Score: 0.35
DE  Interaction: P35579; IntAct: EBI-11098811; Score: 0.35
DE  Interaction: P47755; IntAct: EBI-11117728; Score: 0.35
DE  Interaction: Q9UBB9; IntAct: EBI-24361039; Score: 0.56
DE  Interaction: O14777; IntAct: EBI-24400766; Score: 0.56
DE  Interaction: P14373; IntAct: EBI-25262907; Score: 0.56
DE  Interaction: C5E519; IntAct: EBI-12583021; Score: 0.35
DE  Interaction: P32970; IntAct: EBI-21512742; Score: 0.35
DE  Interaction: Q6PJG9; IntAct: EBI-21552126; Score: 0.35
DE  Interaction: P35414; IntAct: EBI-21559824; Score: 0.35
DE  Interaction: P46059; IntAct: EBI-21560916; Score: 0.35
DE  Interaction: Q14627; IntAct: EBI-21561326; Score: 0.35
DE  Interaction: P21709; IntAct: EBI-21595997; Score: 0.35
DE  Interaction: Q86VU5; IntAct: EBI-21596714; Score: 0.35
DE  Interaction: Q8N6K0; IntAct: EBI-21599984; Score: 0.35
DE  Interaction: O95274; IntAct: EBI-21607810; Score: 0.35
DE  Interaction: P35813; IntAct: EBI-21660332; Score: 0.35
DE  Interaction: Q96D71; IntAct: EBI-21660332; Score: 0.35
DE  Interaction: Q15311; IntAct: EBI-21660332; Score: 0.35
DE  Interaction: Q10567; IntAct: EBI-21660332; Score: 0.35
DE  Interaction: P23246; IntAct: EBI-21660332; Score: 0.35
DE  Interaction: O75688; IntAct: EBI-21660332; Score: 0.35
DE  Interaction: O00291; IntAct: EBI-21660332; Score: 0.35
DE  Interaction: Q96FJ0; IntAct: EBI-21668214; Score: 0.35
DE  Interaction: O60939; IntAct: EBI-21671922; Score: 0.35
DE  Interaction: A2RU67; IntAct: EBI-21694732; Score: 0.35
DE  Interaction: Q9NZQ7; IntAct: EBI-21740460; Score: 0.35
DE  Interaction: Q9NUM3; IntAct: EBI-21748242; Score: 0.35
DE  Interaction: Q8N468; IntAct: EBI-21785908; Score: 0.35
DE  Interaction: O75146; IntAct: EBI-15564862; Score: 0.56
DE  Interaction: P03372; IntAct: EBI-21301141; Score: 0.53
DE  Interaction: Q9BYP7; IntAct: EBI-28946054; Score: 0.35
DE  Interaction: P0DTD8; IntAct: EBI-27127141; Score: 0.35
GO  GO:0016324;
GO  GO:0005938;
GO  GO:0005905;
GO  GO:0030136;
GO  GO:0030665;
GO  GO:0005856;
GO  GO:0005829;
GO  GO:0032839;
GO  GO:0043197;
GO  GO:0043231;
GO  GO:0005739;
GO  GO:0043025;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0014069;
GO  GO:0032587;
GO  GO:0097060;
GO  GO:0051015;
GO  GO:0035615;
GO  GO:0030276;
GO  GO:0032051;
GO  GO:0042802;
GO  GO:0035091;
GO  GO:0005547;
GO  GO:0043325;
GO  GO:0080025;
GO  GO:0005546;
GO  GO:0046982;
GO  GO:0042803;
GO  GO:0017124;
GO  GO:0007015;
GO  GO:0006919;
GO  GO:0006915;
GO  GO:0048268;
GO  GO:0055123;
GO  GO:0006897;
GO  GO:0030837;
GO  GO:0043066;
GO  GO:0034316;
GO  GO:0043065;
GO  GO:1905445;
GO  GO:0045742;
GO  GO:1901030;
GO  GO:2000588;
GO  GO:0032092;
GO  GO:0050821;
GO  GO:0006898;
GO  GO:0032956;
GO  GO:2000369;
GO  GO:0030100;
GO  GO:0060453;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINTQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLPSSS
SQ  ILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWGHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEV
SQ  LEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSC
SQ  LPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEDEEPENLIE
SQ  ISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRK
SQ  QKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ
SQ  SQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALS
SQ  GAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVS
SQ  KLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADR
SQ  LIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRR
SQ  IEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVG
SQ  WGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQI
SQ  EDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPL
SQ  AQKPSVAPRQDHQLDKKDGIYPAQLVNY
//