ID  O75694;
PN  Nuclear pore complex protein Nup155;
GN  NUP155;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:P37199}. Nucleus membrane {ECO:0000250|UniProtKB:P37199}; Peripheral membrane protein {ECO:0000250|UniProtKB:P37199}; Cytoplasmic side {ECO:0000250|UniProtKB:P37199}. Nucleus membrane {ECO:0000250|UniProtKB:P37199}; Peripheral membrane protein {ECO:0000250|UniProtKB:P37199}; Nucleoplasmic side {ECO:0000250|UniProtKB:P37199}. Note=In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis. {ECO:0000250|UniProtKB:P37199}.
DR  UNIPROT: O75694;
DR  UNIPROT: Q9UBE9;
DR  UNIPROT: Q9UFL5;
DR  PDB: 5A9Q;
DR  PDB: 5IJN;
DR  PDB: 5IJO;
DR  PDB: 7PER;
DR  Pfam: PF03177;
DR  Pfam: PF08801;
DR  OMIM: 606694;
DR  OMIM: 615770;
DR  DisGeNET: 9631;
DE  Function: Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. {ECO:0000250|UniProtKB:Q99P88}.
DE  Disease: Atrial fibrillation, familial, 15 (ATFB15) [MIM:615770]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO:0000269|PubMed:19070573}. Note=The disease is caused by variants affecting the gene represented in this entry.
DE  Reference Proteome: Yes;
DE  Interaction: O95405; IntAct: EBI-7255490; Score: 0.37
DE  Interaction: P40337; IntAct: EBI-1062521; Score: 0.00
DE  Interaction: P11802; IntAct: EBI-1065754; Score: 0.00
DE  Interaction: P19532; IntAct: EBI-1070952; Score: 0.00
DE  Interaction: P23508; IntAct: EBI-1072074; Score: 0.00
DE  Interaction: Q9Y4K3; IntAct: EBI-1075999; Score: 0.00
DE  Interaction: P11171; IntAct: EBI-1078988; Score: 0.00
DE  Interaction: P01889; IntAct: EBI-1085884; Score: 0.00
DE  Interaction: Q8IY92; IntAct: EBI-2371120; Score: 0.35
DE  Interaction: Q6GQQ9; IntAct: EBI-2510717; Score: 0.40
DE  Interaction: Q09019; IntAct: EBI-2515767; Score: 0.40
DE  Interaction: Q99P88; IntAct: EBI-2558136; Score: 0.40
DE  Interaction: A0A2U2H2G3; IntAct: EBI-2862410; Score: 0.00
DE  Interaction: Q13573; IntAct: EBI-7950968; Score: 0.35
DE  Interaction: Q99459; IntAct: EBI-7954144; Score: 0.55
DE  Interaction: Q5EWX9; IntAct: EBI-8070469; Score: 0.35
DE  Interaction: Q8WVZ9; IntAct: EBI-3232144; Score: 0.35
DE  Interaction: O95758; IntAct: EBI-7850130; Score: 0.35
DE  Interaction: P98078; IntAct: EBI-6100356; Score: 0.35
DE  Interaction: P19320; IntAct: EBI-6189915; Score: 0.35
DE  Interaction: P02751; IntAct: EBI-6285956; Score: 0.35
DE  Interaction: Q92905; IntAct: EBI-21325777; Score: 0.35
DE  Interaction: Q15843; IntAct: EBI-21328206; Score: 0.35
DE  Interaction: Q13618; IntAct: EBI-21329068; Score: 0.35
DE  Interaction: Q53GS7; IntAct: EBI-8873568; Score: 0.37
DE  Interaction: Q8WYP5; IntAct: EBI-9050350; Score: 0.40
DE  Interaction: O43281; IntAct: EBI-10189017; Score: 0.56
DE  Interaction: Q15637; IntAct: EBI-11299723; Score: 0.00
DE  Interaction: P05412; IntAct: EBI-11323169; Score: 0.35
DE  Interaction: Q9ERU9; IntAct: EBI-10999306; Score: 0.35
DE  Interaction: Q68CZ1; IntAct: EBI-11363154; Score: 0.35
DE  Interaction: Q86VQ0; IntAct: EBI-11363336; Score: 0.35
DE  Interaction: Q86X19; IntAct: EBI-11372615; Score: 0.27
DE  Interaction: Q9P0N5; IntAct: EBI-11378021; Score: 0.27
DE  Interaction: Q66GS9; IntAct: EBI-11386281; Score: 0.27
DE  Interaction: Q86UK5; IntAct: EBI-11389870; Score: 0.27
DE  Interaction: Q8IVT5; IntAct: EBI-14035520; Score: 0.35
DE  Interaction: P43353; IntAct: EBI-21500028; Score: 0.35
DE  Interaction: P09067; IntAct: EBI-21543288; Score: 0.35
DE  Interaction: Q9H813; IntAct: EBI-21593240; Score: 0.35
DE  Interaction: O15155; IntAct: EBI-16788067; Score: 0.27
DE  Interaction: P27824; IntAct: EBI-16788621; Score: 0.27
DE  Interaction: Q96I36; IntAct: EBI-16791250; Score: 0.27
DE  Interaction: P02545; IntAct: EBI-16795756; Score: 0.67
DE  Interaction: Q9HBL7; IntAct: EBI-16797780; Score: 0.27
DE  Interaction: Q15388; IntAct: EBI-16801791; Score: 0.27
DE  Interaction: Q5S007; IntAct: EBI-21360986; Score: 0.35
DE  Interaction: Q8IY21; IntAct: EBI-21259607; Score: 0.35
DE  Interaction: Q9Y586; IntAct: EBI-21261050; Score: 0.35
DE  Interaction: Q15077; IntAct: EBI-21262943; Score: 0.35
DE  Interaction: P51159; IntAct: EBI-21264064; Score: 0.35
DE  Interaction: Q9Y275; IntAct: EBI-21266480; Score: 0.35
DE  Interaction: P0DOF2; IntAct: EBI-25603126; Score: 0.35
DE  Interaction: P0DTC5; IntAct: EBI-26495256; Score: 0.35
DE  Interaction: Q92621; IntAct: EBI-26588212; Score: 0.35
DE  Interaction: P01116; IntAct: EBI-27041844; Score: 0.27
DE  Interaction: P01111; IntAct: EBI-27042293; Score: 0.27
DE  Interaction: P01112; IntAct: EBI-27045317; Score: 0.27
DE  Interaction: A0A0H3NG92; IntAct: EBI-27055968; Score: 0.27
DE  Interaction: A0A0H3NB75; IntAct: EBI-27055983; Score: 0.27
DE  Interaction: P51617; IntAct: EBI-28935882; Score: 0.35
DE  Interaction: Q99952; IntAct: EBI-27114698; Score: 0.35
DE  Interaction: Q92932; IntAct: EBI-27116679; Score: 0.27
DE  Interaction: Q13283; IntAct: EBI-28955349; Score: 0.35
DE  Interaction: Q8WUM4; IntAct: EBI-30834760; Score: 0.44
DE  Interaction: Q9UM73; IntAct: EBI-32719830; Score: 0.27
DE  Interaction: P30530; IntAct: EBI-32719959; Score: 0.27
DE  Interaction: P00533; IntAct: EBI-32720286; Score: 0.27
DE  Interaction: P54756; IntAct: EBI-32720907; Score: 0.27
DE  Interaction: P29322; IntAct: EBI-32721175; Score: 0.27
DE  Interaction: P04626; IntAct: EBI-32721465; Score: 0.27
DE  Interaction: P11362; IntAct: EBI-32721578; Score: 0.27
DE  Interaction: P22607; IntAct: EBI-32721979; Score: 0.27
DE  Interaction: P22455; IntAct: EBI-32722168; Score: 0.27
DE  Interaction: P17948; IntAct: EBI-32722433; Score: 0.27
DE  Interaction: P36888; IntAct: EBI-32722567; Score: 0.27
DE  Interaction: P35916; IntAct: EBI-32722728; Score: 0.27
DE  Interaction: P08069; IntAct: EBI-32722947; Score: 0.27
DE  Interaction: P35968; IntAct: EBI-32723270; Score: 0.27
DE  Interaction: Q12866; IntAct: EBI-32723870; Score: 0.27
DE  Interaction: P04629; IntAct: EBI-32724282; Score: 0.27
DE  Interaction: Q16288; IntAct: EBI-32724526; Score: 0.27
DE  Interaction: P07949; IntAct: EBI-32725031; Score: 0.27
DE  Interaction: Q01973; IntAct: EBI-32725295; Score: 0.27
DE  Interaction: Q6J9G0; IntAct: EBI-32731895; Score: 0.27
GO  GO:0005829;
GO  GO:0016020;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0044611;
GO  GO:0017056;
GO  GO:0086014;
GO  GO:0035196;
GO  GO:0006406;
GO  GO:0006998;
GO  GO:0006913;
GO  GO:0006606;
GO  GO:0036228;
GO  GO:0006405;
GO  GO:0000972;
TP  Membrane Topology: Peripheral; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:P37199};
SQ  MPSSLLGAAMPASTSAAALQEALENAGRLIDRQLQEDRMYPDLSELLMVSAPNNPTVSGMSDMDYPLQGPGLLSVPNLPE
SQ  ISSIRRVPLPPELVEQFGHMQCNCMMGVFPPISRAWLTIDSDIFMWNYEDGGDLAYFDGLSETILAVGLVKPKAGIFQPH
SQ  VRHLLVLATPVDIVILGLSYANLQTGSGVLNDSLSGGMQLLPDPLYSLPTDNTYLLTITSTDNGRIFLAGKDGCLYEVAY
SQ  QAEAGWFSQRCRKINHSKSSLSFLVPSLLQFTFSEDDPILQIAIDNSRNILYTRSEKGVIQVYDLGQDGQGMSRVASVSQ
SQ  NAIVSAAGNIARTIDRSVFKPIVQIAVIENSESLDCQLLAVTHAGVRLYFSTCPFRQPLARPNTLTLVHVRLPPGFSASS
SQ  TVEKPSKVHRALYSKGILLMAASENEDNDILWCVNHDTFPFQKPMMETQMTAGVDGHSWALSAIDELKVDKIITPLNKDH
SQ  IPITDSPVVVQQHMLPPKKFVLLSAQGSLMFHKLRPVDQLRHLLVSNVGGDGEEIERFFKLHQEDQACATCLILACSTAA
SQ  CDREVSAWATRAFFRYGGEAQMRFPTTLPPPSNVGPILGSPVYSSSPVPSGSPYPNPSFLGTPSHGIQPPAMSTPVCALG
SQ  NPATQATNMSCVTGPEIVYSGKHNGICIYFSRIMGNIWDASLVVERIFKSGNREITAIESSVPCQLLESVLQELKGLQEF
SQ  LDRNSQFAGGPLGNPNTTAKVQQRLIGFMRPENGNPQQMQQELQRKFHEAQLSEKISLQAIQQLVRKSYQALALWKLLCE
SQ  HQFTIIVAELQKELQEQLKITTFKDLVIRDKELTGALIASLINCYIRDNAAVDGISLHLQDICPLLYSTDDAICSKANEL
SQ  LQRSRQVQNKTEKERMLRESLKEYQKISNQVDLSNVCAQYRQVRFYEGVVELSLTAAEKKDPQGLGLHFYKHGEPEEDIV
SQ  GLQAFQERLNSYKCITDTLQELVNQSKAAPQSPSVPKKPGPPVLSSDPNMLSNEEAGHHFEQMLKLSQRSKDELFSIALY
SQ  NWLIQVDLADKLLQVASPFLEPHLVRMAKVDQNRVRYMDLLWRYYEKNRSFSNAARVLSRLADMHSTEISLQQRLEYIAR
SQ  AILSAKSSTAISSIAADGEFLHELEEKMEVARIQLQIQETLQRQYSHHSSVQDAVSQLDSELMDITKLYGEFADPFKLAE
SQ  CKLAIIHCAGYSDPILVQTLWQDIIEKELSDSVTLSSSDRMHALSLKIVLLGKIYAGTPRFFPLDFIVQFLEQQVCTLNW
SQ  DVGFVIQTMNEIGVPLPRLLEVYDQLFKSRDPFWNRMKKPLHLLDCIHVLLIRYVENPSQVLNCERRRFTNLCLDAVCGY
SQ  LVELQSMSSSVAVQAITGNFKSLQAKLERLH
//