ID  O76083;
PN  High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A;
GN  PDE9A;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: [Isoform PDE9A1]: Cell projection, ruffle membrane {ECO:0000269|PubMed:17090334}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17090334}. Golgi apparatus {ECO:0000269|PubMed:17090334}. Endoplasmic reticulum {ECO:0000269|PubMed:17090334}. Cell membrane, sarcolemma {ECO:0000269|PubMed:25799991}. [Isoform PDE9A2]: Cell projection, ruffle membrane {ECO:0000269|PubMed:17090334}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17090334}. [Isoform PDE9A3]: Cytoplasm {ECO:0000269|PubMed:17090334}. Endoplasmic reticulum {ECO:0000269|PubMed:17090334}. [Isoform PDE9A17]: Cytoplasm {ECO:0000269|PubMed:17090334}. Endoplasmic reticulum {ECO:0000269|PubMed:17090334}.
DR  UNIPROT: O76083;
DR  UNIPROT: B2RBI5;
DR  UNIPROT: B4DFI5;
DR  UNIPROT: D3DSJ8;
DR  UNIPROT: D3DSJ9;
DR  UNIPROT: O75490;
DR  UNIPROT: O75491;
DR  UNIPROT: O95225;
DR  UNIPROT: Q53Y40;
DR  UNIPROT: Q5QD39;
DR  UNIPROT: Q86SF7;
DR  UNIPROT: Q86SI6;
DR  UNIPROT: Q86SJ3;
DR  UNIPROT: Q86WN3;
DR  UNIPROT: Q86WN4;
DR  UNIPROT: Q86WN5;
DR  UNIPROT: Q86WN6;
DR  UNIPROT: Q86WN7;
DR  UNIPROT: Q86WN8;
DR  UNIPROT: Q86WN9;
DR  UNIPROT: Q86WP0;
DR  PDB: 2HD1;
DR  PDB: 2YY2;
DR  PDB: 3DY8;
DR  PDB: 3DYL;
DR  PDB: 3DYN;
DR  PDB: 3DYQ;
DR  PDB: 3DYS;
DR  PDB: 3JSI;
DR  PDB: 3JSW;
DR  PDB: 3K3E;
DR  PDB: 3K3H;
DR  PDB: 3N3Z;
DR  PDB: 3QI3;
DR  PDB: 3QI4;
DR  PDB: 4E90;
DR  PDB: 4G2J;
DR  PDB: 4G2L;
DR  PDB: 4GH6;
DR  PDB: 4Y86;
DR  PDB: 4Y87;
DR  PDB: 4Y8C;
DR  PDB: 6A3N;
DR  PDB: 6LZZ;
DR  PDB: 7F0I;
DR  Pfam: PF00233;
DR  PROSITE: PS00126;
DR  PROSITE: PS51845;
DR  OMIM: 602973;
DR  DisGeNET: 5152;
DE  Function: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity). {ECO:0000250|UniProtKB:Q8QZV1, ECO:0000269|PubMed:18757755, ECO:0000269|PubMed:21483814, ECO:0000269|PubMed:25799991, ECO:0000269|PubMed:9624146, ECO:0000305}.
DE  Reference Proteome: Yes;
DE  Interaction: Q13049; IntAct: EBI-753319; Score: 0.88
DE  Interaction: Q96FC7; IntAct: EBI-10285664; Score: 0.56
DE  Interaction: O76083; IntAct: EBI-16433405; Score: 0.56
DE  Interaction: Q8NAJ2; IntAct: EBI-10173127; Score: 0.56
DE  Interaction: P60410; IntAct: EBI-10190681; Score: 0.56
DE  Interaction: Q7Z3S9; IntAct: EBI-10190711; Score: 0.67
DE  Interaction: Q9BYQ4; IntAct: EBI-10190721; Score: 0.56
DE  Interaction: Q9BYR5; IntAct: EBI-10190731; Score: 0.56
DE  Interaction: O95817; IntAct: EBI-10192173; Score: 0.56
DE  Interaction: P25791; IntAct: EBI-10202658; Score: 0.56
DE  Interaction: P49759; IntAct: EBI-10211130; Score: 0.56
DE  Interaction: P49888; IntAct: EBI-10211543; Score: 0.56
DE  Interaction: Q14657; IntAct: EBI-10233665; Score: 0.56
DE  Interaction: Q49AN0; IntAct: EBI-10241753; Score: 0.56
DE  Interaction: Q9BRA0; IntAct: EBI-10296698; Score: 0.56
DE  Interaction: Q9BRU9; IntAct: EBI-10297143; Score: 0.56
DE  Interaction: Q9H8Y8; IntAct: EBI-10309418; Score: 0.67
DE  Interaction: Q9Y260; IntAct: EBI-10325620; Score: 0.56
DE  Interaction: P25377; IntAct: EBI-11524546; Score: 0.56
DE  Interaction: P32502; IntAct: EBI-11525726; Score: 0.56
DE  Interaction: P38744; IntAct: EBI-11529381; Score: 0.56
DE  Interaction: P39518; IntAct: EBI-11529837; Score: 0.56
DE  Interaction: P40454; IntAct: EBI-11530904; Score: 0.56
DE  Interaction: Q00618; IntAct: EBI-11534143; Score: 0.56
DE  Interaction: Q12259; IntAct: EBI-11536954; Score: 0.56
DE  Interaction: O00560; IntAct: EBI-24276653; Score: 0.56
DE  Interaction: P61964; IntAct: EBI-24286856; Score: 0.56
DE  Interaction: O15205; IntAct: EBI-24291537; Score: 0.56
DE  Interaction: P26371; IntAct: EBI-24298959; Score: 0.56
DE  Interaction: Q99633; IntAct: EBI-24316761; Score: 0.56
DE  Interaction: Q16649; IntAct: EBI-24491918; Score: 0.56
DE  Interaction: Q15051; IntAct: EBI-24524430; Score: 0.56
DE  Interaction: P59991; IntAct: EBI-24372163; Score: 0.56
DE  Interaction: A8MQ03; IntAct: EBI-24378365; Score: 0.56
DE  Interaction: P60411; IntAct: EBI-24407802; Score: 0.56
DE  Interaction: Q63ZY3; IntAct: EBI-24409161; Score: 0.56
DE  Interaction: P60328; IntAct: EBI-25262737; Score: 0.56
DE  Interaction: Q07627; IntAct: EBI-24418030; Score: 0.56
DE  Interaction: Q8IUG1; IntAct: EBI-24436343; Score: 0.56
DE  Interaction: O76011; IntAct: EBI-24437958; Score: 0.56
DE  Interaction: Q16543; IntAct: EBI-24460241; Score: 0.56
DE  Interaction: P60409; IntAct: EBI-24468187; Score: 0.56
DE  Interaction: Q96DX4; IntAct: EBI-11903808; Score: 0.00
DE  Interaction: Q8TAD7; IntAct: EBI-11903800; Score: 0.00
DE  Interaction: Q7Z494; IntAct: EBI-11903789; Score: 0.00
DE  Interaction: Q13237; IntAct: EBI-11903780; Score: 0.00
DE  Interaction: Q13432; IntAct: EBI-21558921; Score: 0.35
DE  Interaction: P51114; IntAct: EBI-26510978; Score: 0.37
DE  Interaction: P51116; IntAct: EBI-26512056; Score: 0.37
GO  GO:0005829;
GO  GO:0005783;
GO  GO:0005794;
GO  GO:0005654;
GO  GO:0043204;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0032587;
GO  GO:0042383;
GO  GO:0047555;
GO  GO:0004114;
GO  GO:0042802;
GO  GO:0046872;
GO  GO:0046069;
GO  GO:0046068;
GO  GO:0019934;
GO  GO:0010613;
GO  GO:0007165;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRP
SQ  VAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQV
SQ  AEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
SQ  PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV
SQ  AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNI
SQ  FSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
SQ  LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAM
SQ  KELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
//