ID  O88735;
PN  Ensconsin;
GN  Map7;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:14517216}. Basolateral cell membrane {ECO:0000269|PubMed:14517216}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14517216}. Note=Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte terminal differentiation from microtubules with a perinuclear localization to cortical microtubules organized in spike- like bundles facing intercellular contacts.
DR  UNIPROT: O88735;
DR  UNIPROT: Q3V0B9;
DR  UNIPROT: Q7TQL9;
DR  UNIPROT: Q80V60;
DR  Pfam: PF05672;
DE  Function: Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:14517216}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9QWI6; IntAct: EBI-27100778; Score: 0.35
GO  GO:0030424;
GO  GO:0016323;
GO  GO:0005829;
GO  GO:0005874;
GO  GO:0015630;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0005102;
GO  GO:0000902;
GO  GO:0008283;
GO  GO:0009566;
GO  GO:0007281;
GO  GO:0006687;
GO  GO:0048872;
GO  GO:0033327;
GO  GO:0001578;
GO  GO:0000226;
GO  GO:0006997;
GO  GO:0035265;
GO  GO:0072659;
GO  GO:0006970;
GO  GO:0032526;
GO  GO:0060009;
GO  GO:0007283;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAEQGAGGDGHRGGDGATHSDPASDGYKVQEKRTAPSRPTSTVSGQTSNHSGNKPDPPPVLRVDDRQRLARERREEREKQ
SQ  LAARETVWLEREERARQHYERHLEARKKKLEDQRLKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPRQKSNRW
SQ  SWGSPLHGSSSIHSGDPDRRSVSTMNLSKHVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVSRLLTPTHSFLARS
SQ  KSTAALSGDTASCSPIIMPFKAAHSRNPVDRPKLFVTPPEGSARRRTIHGLASHKREREREHVPFHVSPGARRTLSPSNL
SQ  KARSPAPARLWLPSKSMPHLPGTPRPASSLPPGSVRAASAQAPSSSPGNIRPFKREVKVEPEKKDPLPAVKSRVPLVKVE
SQ  EVTVEEGTPVKPPEPAAPASAPIATPAPAPATDPAPVPAPSSTVTVGVVPKTSAGTTDPEEATRLLAEKRRLAREQREKE
SQ  ERERKEKEELERQKIEELARRVAEERSRREEEARRLEEEQAREKEELALRLAEEERERWEREEVERVQKQKEEEARAREE
SQ  AERARQEREKHFQKEEQERLERKKRLEEIMRRTRRTETADKKTTEQRNGDIAKGVLTGEPEVPALPCMASSGNGESAESP
SQ  HGVALQQSEVTTESSPDLEKQPNENGMSIQNENFEEVINLPVGSKASRLDVTNENPEIPLKPILAFNDEGTLGPLPQVDG
SQ  VQTQQTAEVI
//