ID  O94901;
PN  SUN domain-containing protein 1;
GN  SUN1;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus inner membrane {ECO:0000269|PubMed:12958361, ECO:0000269|PubMed:16445915, ECO:0000269|PubMed:17132086, ECO:0000269|PubMed:18845190, ECO:0000269|PubMed:19933576}; Single-pass type II membrane protein {ECO:0000269|PubMed:12958361, ECO:0000269|PubMed:16445915, ECO:0000269|PubMed:17132086, ECO:0000269|PubMed:18845190, ECO:0000269|PubMed:19933576}. Note=At oocyte MI stage localized around the spindle, at MII stage localized to the spindle poles. {ECO:0000250|UniProtKB:Q9D666}.
DR  UNIPROT: O94901;
DR  UNIPROT: A5PL20;
DR  UNIPROT: B3KMV7;
DR  UNIPROT: B4DZF7;
DR  UNIPROT: B7WNY4;
DR  UNIPROT: B7WP53;
DR  UNIPROT: E9PDU4;
DR  UNIPROT: E9PF23;
DR  UNIPROT: F8WD13;
DR  UNIPROT: Q96CZ7;
DR  UNIPROT: Q9HA14;
DR  UNIPROT: Q9UH98;
DR  PDB: 6R15;
DR  PDB: 6R16;
DR  PDB: 6R2I;
DR  PDB: 7E34;
DR  Pfam: PF18580;
DR  Pfam: PF09387;
DR  Pfam: PF07738;
DR  PROSITE: PS51469;
DR  OMIM: 607723;
DR  DisGeNET: 23353;
DE  Function: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:18039933, PubMed:18396275). The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity). Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity). May be involved in nuclear remodeling during sperm head formation in spermatogenesis (By similarity). May play a role in DNA repair by suppressing non- homologous end joining repair to facilitate the repair of DNA cross- links (PubMed:24375709). {ECO:0000250|UniProtKB:Q9D666, ECO:0000269|PubMed:18039933, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:24375709}.
DE  Reference Proteome: Yes;
DE  Interaction: Q5NFR9; IntAct: EBI-2796914; Score: 0.00
DE  Interaction: Q8NF91; IntAct: EBI-6163229; Score: 0.52
DE  Interaction: Q8WXH0; IntAct: EBI-6163348; Score: 0.52
DE  Interaction: O94901; IntAct: EBI-6171008; Score: 0.40
DE  Interaction: P04578; IntAct: EBI-6174316; Score: 0.46
DE  Interaction: P06461; IntAct: EBI-11723785; Score: 0.35
DE  Interaction: Q6NUS6; IntAct: EBI-11368748; Score: 0.27
DE  Interaction: Q9P0N5; IntAct: EBI-11398030; Score: 0.27
DE  Interaction: Q80VJ8; IntAct: EBI-11685143; Score: 0.27
DE  Interaction: Q9Y6Q1; IntAct: EBI-21501330; Score: 0.35
DE  Interaction: Q86UE6; IntAct: EBI-21507777; Score: 0.35
DE  Interaction: P16444; IntAct: EBI-21514808; Score: 0.35
DE  Interaction: Q8TCN5; IntAct: EBI-21528943; Score: 0.35
DE  Interaction: Q15654; IntAct: EBI-21528943; Score: 0.35
DE  Interaction: A2RUC4; IntAct: EBI-21528943; Score: 0.35
DE  Interaction: Q8WWF5; IntAct: EBI-21589535; Score: 0.35
DE  Interaction: Q9BQ31; IntAct: EBI-21590203; Score: 0.35
DE  Interaction: Q8N6G5; IntAct: EBI-21622328; Score: 0.35
DE  Interaction: Q9NVF7; IntAct: EBI-21671334; Score: 0.35
DE  Interaction: Q53F39; IntAct: EBI-21694305; Score: 0.35
DE  Interaction: Q6AZY7; IntAct: EBI-21722497; Score: 0.35
DE  Interaction: Q401N2; IntAct: EBI-21749859; Score: 0.35
DE  Interaction: P14625; IntAct: EBI-20908648; Score: 0.40
DE  Interaction: P14404; IntAct: EBI-21028244; Score: 0.35
DE  Interaction: P50402; IntAct: EBI-22057164; Score: 0.46
DE  Interaction: P02545; IntAct: EBI-22057187; Score: 0.40
DE  Interaction: P0DOF2; IntAct: EBI-25603126; Score: 0.35
DE  Interaction: O95476; IntAct: EBI-27115722; Score: 0.27
GO  GO:0005737;
GO  GO:0005639;
GO  GO:0043231;
GO  GO:0034993;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0140444;
GO  GO:0005521;
GO  GO:0043495;
GO  GO:0051642;
GO  GO:0007129;
GO  GO:0070197;
GO  GO:0006998;
GO  GO:0090292;
GO  GO:0021817;
GO  GO:0007283;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis;
SQ  MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSA
SQ  VSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSHGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKG
SQ  GNKAAIQGNGDVGAAAATAHNGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQKCYFLLQILRRIGAVGQAVSRT
SQ  AWSALWLAVVAPGKAASGVFWWLGIGWYQFVTLISWLNVFLLTRCLRNICKFLVLLIPLFLLLAGLSLRGQGNFFSFLPV
SQ  LNWASMHRTQRVDDPQDVFKPTTSRLKQPLQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKLQARVDQM
SQ  EGGAAGPSASVRDAVGQPPRETDFMAFHQEHEVRMSHLEDILGKLREKSEAIQKELEQTKQKTISAVGEQLLPTVEHLQL
SQ  ELDQLKSELSSWRHVKTGCETVDAVQERVDVQVREMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQILR
SQ  NVTHHVSVTKQLPTSEAVVSAVSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFALESGGGSILSTRCSETYETKTAL
SQ  MSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLSPTGNISSAPKDFAVYGLEN
SQ  EYQEEGQLLGQFTYDQDGESLQMFQALKRPDDTAFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK
//