ID  O94972;
PN  E3 ubiquitin-protein ligase TRIM37;
GN  TRIM37;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:15885686}. Peroxisome {ECO:0000269|PubMed:11938494}. Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. {ECO:0000269|PubMed:15885686}.
DR  UNIPROT: O94972;
DR  UNIPROT: A8K0V9;
DR  UNIPROT: A8K8U4;
DR  UNIPROT: A8MZ79;
DR  UNIPROT: B4DGZ3;
DR  UNIPROT: F8WEE6;
DR  UNIPROT: Q7Z3E6;
DR  UNIPROT: Q8IYF7;
DR  UNIPROT: Q8WYF7;
DR  PDB: 3LRQ;
DR  Pfam: PF00917;
DR  Pfam: PF00643;
DR  PROSITE: PS50144;
DR  PROSITE: PS50119;
DR  PROSITE: PS50089;
DR  OMIM: 253250;
DR  OMIM: 605073;
DR  DisGeNET: 4591;
DE  Function: E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724). {ECO:0000269|PubMed:15885686, ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24317724, ECO:0000269|PubMed:25470042}.
DE  Disease: Mulibrey nanism (MUL) [MIM:253250]: An autosomal recessive growth disorder characterized by severe growth failure of prenatal onset, constrictive pericardium and progressive cardiomyopathy, facial dysmorphism, and failure of sexual maturation. Additional clinical features include hepatomegaly, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, hypoplasia of various endocrine glands, insulin resistance with type 2 diabetes, and an increased risk for Wilms' tumor. {ECO:0000269|PubMed:10888877, ECO:0000269|PubMed:12754710, ECO:0000269|PubMed:15108285, ECO:0000269|PubMed:15885686, ECO:0000269|PubMed:17100991, ECO:0000269|PubMed:17551331, ECO:0000269|PubMed:21865362, ECO:0000269|PubMed:23385855}. Note=The disease is caused by variants affecting the gene represented in this entry.
DE  Reference Proteome: Yes;
DE  Interaction: O43663; IntAct: EBI-761001; Score: 0.63
DE  Interaction: Q9H5Z6; IntAct: EBI-752977; Score: 0.55
DE  Interaction: Q96M61; IntAct: EBI-753037; Score: 0.37
DE  Interaction: Q8IYF1; IntAct: EBI-753112; Score: 0.37
DE  Interaction: Q9UBZ4; IntAct: EBI-753262; Score: 0.37
DE  Interaction: P51116; IntAct: EBI-753616; Score: 0.37
DE  Interaction: O95990; IntAct: EBI-10192918; Score: 0.56
DE  Interaction: Q9H4K1; IntAct: EBI-754930; Score: 0.37
DE  Interaction: Q8TCX5; IntAct: EBI-755044; Score: 0.37
DE  Interaction: Q13895; IntAct: EBI-755389; Score: 0.78
DE  Interaction: Q8N720; IntAct: EBI-755725; Score: 0.37
DE  Interaction: Q15398; IntAct: EBI-756466; Score: 0.37
DE  Interaction: Q96T60; IntAct: EBI-756790; Score: 0.67
DE  Interaction: P53618; IntAct: EBI-757102; Score: 0.67
DE  Interaction: Q6ZU52; IntAct: EBI-757480; Score: 0.37
DE  Interaction: Q8TAU3; IntAct: EBI-758119; Score: 0.67
DE  Interaction: Q7L590; IntAct: EBI-758425; Score: 0.55
DE  Interaction: Q01844; IntAct: EBI-758560; Score: 0.37
DE  Interaction: Q96EZ8; IntAct: EBI-758704; Score: 0.67
DE  Interaction: Q6ZVK8; IntAct: EBI-758902; Score: 0.37
DE  Interaction: Q96KB5; IntAct: EBI-759697; Score: 0.37
DE  Interaction: Q7Z2E3; IntAct: EBI-956382; Score: 0.00
DE  Interaction: Q5VVX9; IntAct: EBI-2130409; Score: 0.37
DE  Interaction: Q8N5R6; IntAct: EBI-2320558; Score: 0.37
DE  Interaction: P62256; IntAct: EBI-2341474; Score: 0.37
DE  Interaction: P58526; IntAct: EBI-2851623; Score: 0.00
DE  Interaction: Q96SN8; IntAct: EBI-3919380; Score: 0.37
DE  Interaction: P08238; IntAct: EBI-6427394; Score: 0.40
DE  Interaction: Q7TSJ6; IntAct: EBI-8800022; Score: 0.27
DE  Interaction: P88980; IntAct: EBI-9640232; Score: 0.37
DE  Interaction: A8K932; IntAct: EBI-10174682; Score: 0.56
DE  Interaction: Q2TBE0; IntAct: EBI-10174987; Score: 0.72
DE  Interaction: P26196; IntAct: EBI-10203749; Score: 0.56
DE  Interaction: P32969; IntAct: EBI-10206109; Score: 0.56
DE  Interaction: P57075; IntAct: EBI-10215794; Score: 0.56
DE  Interaction: Q3B820; IntAct: EBI-10240229; Score: 0.56
DE  Interaction: Q86UD4; IntAct: EBI-10258857; Score: 0.56
DE  Interaction: Q86Y33; IntAct: EBI-10260502; Score: 0.56
DE  Interaction: Q92993; IntAct: EBI-10279849; Score: 0.56
DE  Interaction: Q96NC0; IntAct: EBI-10291622; Score: 0.56
DE  Interaction: Q9BWG6; IntAct: EBI-10300546; Score: 0.56
DE  Interaction: Q9Y247; IntAct: EBI-10325546; Score: 0.56
DE  Interaction: Q9Y272; IntAct: EBI-10325762; Score: 0.56
DE  Interaction: Q9Y2D8; IntAct: EBI-10326014; Score: 0.66
DE  Interaction: X5D778; IntAct: EBI-21247082; Score: 0.37
DE  Interaction: X5DP31; IntAct: EBI-21247741; Score: 0.37
DE  Interaction: Q68CZ1; IntAct: EBI-11363154; Score: 0.42
DE  Interaction: Q6ZU80; IntAct: EBI-11370150; Score: 0.27
DE  Interaction: Q8N0Z3; IntAct: EBI-11392023; Score: 0.27
DE  Interaction: Q8N137; IntAct: EBI-11392655; Score: 0.27
DE  Interaction: Q96KN7; IntAct: EBI-11395685; Score: 0.27
DE  Interaction: Q96MT8; IntAct: EBI-11396049; Score: 0.27
DE  Interaction: Q96ST8; IntAct: EBI-11396670; Score: 0.27
DE  Interaction: P32571; IntAct: EBI-11526650; Score: 0.56
DE  Interaction: P39009; IntAct: EBI-11529791; Score: 0.56
DE  Interaction: Q12417; IntAct: EBI-11537369; Score: 0.56
DE  Interaction: Q6P5F9; IntAct: EBI-11603310; Score: 0.35
DE  Interaction: A0A0S2Z4G9; IntAct: EBI-16432706; Score: 0.56
DE  Interaction: A0A0S2Z4M1; IntAct: EBI-16432696; Score: 0.56
DE  Interaction: O15169; IntAct: EBI-16432686; Score: 0.56
DE  Interaction: P28702; IntAct: EBI-16432716; Score: 0.56
DE  Interaction: Q8N8B7; IntAct: EBI-24299182; Score: 0.56
DE  Interaction: Q8IVW4; IntAct: EBI-24321007; Score: 0.56
DE  Interaction: O43167; IntAct: EBI-24327690; Score: 0.56
DE  Interaction: P29972; IntAct: EBI-24333819; Score: 0.56
DE  Interaction: Q14241; IntAct: EBI-25244007; Score: 0.56
DE  Interaction: Q96C24; IntAct: EBI-24364517; Score: 0.56
DE  Interaction: O00311; IntAct: EBI-24370073; Score: 0.56
DE  Interaction: Q8IYY4; IntAct: EBI-24385646; Score: 0.56
DE  Interaction: Q96SQ5; IntAct: EBI-24388285; Score: 0.56
DE  Interaction: O60941; IntAct: EBI-24406639; Score: 0.56
DE  Interaction: Q7Z398; IntAct: EBI-21528160; Score: 0.35
DE  Interaction: Q13042; IntAct: EBI-21544527; Score: 0.35
DE  Interaction: Q6IBW4; IntAct: EBI-21600868; Score: 0.35
DE  Interaction: O14978; IntAct: EBI-21712468; Score: 0.35
DE  Interaction: Q8IWZ6; IntAct: EBI-21737366; Score: 0.35
DE  Interaction: Q0VGE8; IntAct: EBI-21783788; Score: 0.35
DE  Interaction: Q9UL59; IntAct: EBI-21784336; Score: 0.35
DE  Interaction: Q96GS4; IntAct: EBI-21795617; Score: 0.35
DE  Interaction: Q6XPS3; IntAct: EBI-21801323; Score: 0.35
DE  Interaction: Q13398; IntAct: EBI-21807860; Score: 0.35
DE  Interaction: Q9BWM5; IntAct: EBI-21807951; Score: 0.35
DE  Interaction: Q8N9Z0; IntAct: EBI-21807908; Score: 0.35
DE  Interaction: P07305; IntAct: EBI-20925498; Score: 0.40
DE  Interaction: P54764; IntAct: EBI-21380558; Score: 0.00
DE  Interaction: Q9NRI5; IntAct: EBI-21380573; Score: 0.00
DE  Interaction: P53778; IntAct: EBI-28938491; Score: 0.35
DE  Interaction: Q14145; IntAct: EBI-30821612; Score: 0.44
GO  GO:0016235;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0048471;
GO  GO:0005777;
GO  GO:0003682;
GO  GO:0042803;
GO  GO:0003713;
GO  GO:0005164;
GO  GO:0061630;
GO  GO:0031625;
GO  GO:0004842;
GO  GO:0008270;
GO  GO:0070842;
GO  GO:0035518;
GO  GO:0036353;
GO  GO:0046600;
GO  GO:0032088;
GO  GO:0000122;
GO  GO:0051091;
GO  GO:0051092;
GO  GO:0051865;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLRELVNCRWAEEVTQQLDTLQ
SQ  LCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWGGMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISL
SQ  VQEVERNVEAVRNAKDERVREIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISK
SQ  SSEILMMFQQVHRKPMASFVTTPVPPDFTSELVPSYDSATFVLENFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVV
SQ  RGYYLSVFLELSAGLPETSKYEYRVEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNPQNDTVILR
SQ  FQVRSPTFFQKSRDQHWYITQLEAAQTSYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQNDDALETRAKKSACSDM
SQ  LLEGGPTTASVREAKEDEEDEEKIQNEDYHHELSDGDLDLDLVYEDEVNQLDGSSSSASSTATSNTEENDIDEETMSGEN
SQ  DVEYNNMELEEGELMEDAAAAGPAGSSHGYVGSSSRISRRTHLCSAATSSLLDIDPLILIHLLDLKDRSSIENLWGLQPR
SQ  PPASLLQPTASYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKNTLSEIKSSSAASGDMQTSLFSADQAA
SQ  LAACGTENSGRLQDLGMELLAKSSVANCYIRNSTNKKSNSPKPARSSVAGSLSLRRAVDPGENSRSKGDCQTLSEGSPGS
SQ  SQSGSRHSSPRALIHGSIGDILPKTEDRQCKALDSDAVVVAVFSGLPAVEKRRKMVTLGANAKGGHLEGLQMTDLENNSE
SQ  TGELQPVLPEGASAAPEEGMSSDSDIECDTENEEQEEHTSVGGFHDSFMVMTQPPDEDTHSSFPDGEQIGPEDLSFNTDE
SQ  NSGR
//