ID  O95271;
PN  Poly [ADP-ribose] polymerase tankyrase-1;
GN  TNKS;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0185;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:10523501, ECO:0000269|PubMed:21799911, ECO:0000269|PubMed:22864114}. Golgi apparatus membrane {ECO:0000269|PubMed:22864114}; Peripheral membrane protein {ECO:0000269|PubMed:22864114}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10523501, ECO:0000269|PubMed:21799911}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:10523501}. Chromosome, telomere {ECO:0000305|PubMed:9822378}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16076287}. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles (PubMed:22864114). A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres (PubMed:10523501). During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1 (PubMed:12768206). Localizes to spindle poles at mitosis onset via interaction with NUMA1 (PubMed:12080061). {ECO:0000269|PubMed:10523501, ECO:0000269|PubMed:12080061, ECO:0000269|PubMed:12768206, ECO:0000269|PubMed:22864114}.
DR  UNIPROT: O95271;
DR  UNIPROT: O95272;
DR  UNIPROT: Q4G0F2;
DR  UNIPROT: Q59FX0;
DR  PDB: 2RF5;
DR  PDB: 3UDD;
DR  PDB: 3UH2;
DR  PDB: 3UH4;
DR  PDB: 4DVI;
DR  PDB: 4I9I;
DR  PDB: 4K4E;
DR  PDB: 4K4F;
DR  PDB: 4KRS;
DR  PDB: 4LI6;
DR  PDB: 4LI7;
DR  PDB: 4LI8;
DR  PDB: 4MSG;
DR  PDB: 4MSK;
DR  PDB: 4MT9;
DR  PDB: 4N3R;
DR  PDB: 4N4V;
DR  PDB: 4OA7;
DR  PDB: 4TOR;
DR  PDB: 4TOS;
DR  PDB: 4U6A;
DR  PDB: 4UUH;
DR  PDB: 4UW1;
DR  PDB: 4W5S;
DR  PDB: 4W6E;
DR  PDB: 5EBT;
DR  PDB: 5ECE;
DR  PDB: 5ETY;
DR  PDB: 5GP7;
DR  PDB: 5JHQ;
DR  PDB: 5JTI;
DR  PDB: 5JU5;
DR  PDB: 5KNI;
DR  PDB: 6QXU;
DR  PDB: 6URQ;
DR  PDB: 7KKM;
DR  PDB: 7KKN;
DR  PDB: 7KKO;
DR  PDB: 7KKP;
DR  PDB: 7KKQ;
DR  Pfam: PF00023;
DR  Pfam: PF12796;
DR  Pfam: PF13606;
DR  Pfam: PF13637;
DR  Pfam: PF13857;
DR  Pfam: PF00644;
DR  Pfam: PF07647;
DR  PROSITE: PS50297;
DR  PROSITE: PS50088;
DR  PROSITE: PS51059;
DR  PROSITE: PS50105;
DR  OMIM: 603303;
DR  DisGeNET: 8658;
DE  Function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly- ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245). {ECO:0000269|PubMed:10988299, ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:22864114, ECO:0000269|PubMed:23622245, ECO:0000269|PubMed:25043379}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9NRI5; IntAct: EBI-1106475; Score: 0.00
DE  Interaction: O60239; IntAct: EBI-1106480; Score: 0.00
DE  Interaction: Q96RU3; IntAct: EBI-1111242; Score: 0.60
DE  Interaction: Q9NWV8; IntAct: EBI-2514464; Score: 0.56
DE  Interaction: A0A5P8YFM9; IntAct: EBI-2841120; Score: 0.00
DE  Interaction: P54274; IntAct: EBI-8146932; Score: 0.71
DE  Interaction: O95271; IntAct: EBI-8152907; Score: 0.40
DE  Interaction: Q9NWT6; IntAct: EBI-8565753; Score: 0.78
DE  Interaction: Q9Y2T1; IntAct: EBI-4400023; Score: 0.35
DE  Interaction: O35625; IntAct: EBI-4400085; Score: 0.58
DE  Interaction: O15084; IntAct: EBI-5653887; Score: 0.00
DE  Interaction: Q06649; IntAct: EBI-5328405; Score: 0.40
DE  Interaction: Q9HC77; IntAct: EBI-7924713; Score: 0.46
DE  Interaction: O43303; IntAct: EBI-7925293; Score: 0.27
DE  Interaction: P34969; IntAct: EBI-9027817; Score: 0.35
DE  Interaction: P62826; IntAct: EBI-9692184; Score: 0.40
DE  Interaction: O95235; IntAct: EBI-11007956; Score: 0.35
DE  Interaction: P80314; IntAct: EBI-11019324; Score: 0.35
DE  Interaction: Q3UES3; IntAct: EBI-11025889; Score: 0.35
DE  Interaction: O75367; IntAct: EBI-11506883; Score: 0.52
DE  Interaction: Q6P5F9; IntAct: EBI-11603310; Score: 0.35
DE  Interaction: O00560; IntAct: EBI-24280426; Score: 0.56
DE  Interaction: Q9Y530; IntAct: EBI-24310113; Score: 0.56
DE  Interaction: P56279; IntAct: EBI-24345984; Score: 0.56
DE  Interaction: Q7L775; IntAct: EBI-25257538; Score: 0.56
DE  Interaction: Q9NX46; IntAct: EBI-24383999; Score: 0.56
DE  Interaction: Q8TF42; IntAct: EBI-24458289; Score: 0.56
DE  Interaction: A4D1S0; IntAct: EBI-21511461; Score: 0.35
DE  Interaction: Q96CW1; IntAct: EBI-21520588; Score: 0.35
DE  Interaction: O60232; IntAct: EBI-21543889; Score: 0.35
DE  Interaction: Q96A37; IntAct: EBI-21627270; Score: 0.35
DE  Interaction: Q9H201; IntAct: EBI-21644009; Score: 0.35
DE  Interaction: Q5SW79; IntAct: EBI-21644990; Score: 0.35
DE  Interaction: Q9UPT6; IntAct: EBI-21663692; Score: 0.35
DE  Interaction: Q07954; IntAct: EBI-21684279; Score: 0.35
DE  Interaction: Q6P1L5; IntAct: EBI-21690977; Score: 0.35
DE  Interaction: Q7L8J4; IntAct: EBI-21713418; Score: 0.35
DE  Interaction: Q8N6W0; IntAct: EBI-21727590; Score: 0.35
DE  Interaction: Q2T9K0; IntAct: EBI-21768445; Score: 0.35
DE  Interaction: Q9BS91; IntAct: EBI-21804617; Score: 0.59
DE  Interaction: Q9H2G9; IntAct: EBI-21813197; Score: 0.59
DE  Interaction: Q9BSI4; IntAct: EBI-21813154; Score: 0.35
DE  Interaction: Q86WJ1; IntAct: EBI-21813081; Score: 0.35
DE  Interaction: O75298; IntAct: EBI-21813019; Score: 0.35
DE  Interaction: O60547; IntAct: EBI-21813000; Score: 0.35
DE  Interaction: Q9NTX7; IntAct: EBI-16124474; Score: 0.73
DE  Interaction: Q3KP66; IntAct: EBI-20715953; Score: 0.59
DE  Interaction: P12956; IntAct: EBI-20904600; Score: 0.40
DE  Interaction: P21709; IntAct: EBI-21390848; Score: 0.00
DE  Interaction: Q8TER5; IntAct: EBI-25410884; Score: 0.35
DE  Interaction: Q9C0C2; IntAct: EBI-28963818; Score: 0.40
DE  Interaction: Q9UIQ6; IntAct: EBI-28963830; Score: 0.40
DE  Interaction: Q14980; IntAct: EBI-28964088; Score: 0.61
DE  Interaction: Q16281; IntAct: EBI-30838012; Score: 0.44
DE  Interaction: Q15019; IntAct: EBI-30837990; Score: 0.44
DE  Interaction: Q14CM0; IntAct: EBI-30837979; Score: 0.44
DE  Interaction: Q14764; IntAct: EBI-30837957; Score: 0.44
DE  Interaction: Q14689; IntAct: EBI-30837946; Score: 0.44
DE  Interaction: Q14574; IntAct: EBI-30837935; Score: 0.44
DE  Interaction: Q14249; IntAct: EBI-30837924; Score: 0.44
DE  Interaction: Q13813; IntAct: EBI-30837913; Score: 0.44
DE  Interaction: Q13698; IntAct: EBI-30837902; Score: 0.44
DE  Interaction: Q13367; IntAct: EBI-30837891; Score: 0.44
DE  Interaction: Q13111; IntAct: EBI-30837880; Score: 0.44
DE  Interaction: Q12802; IntAct: EBI-30837869; Score: 0.44
DE  Interaction: Q03468; IntAct: EBI-30837858; Score: 0.44
DE  Interaction: P78314; IntAct: EBI-30837847; Score: 0.44
DE  Interaction: P62955; IntAct: EBI-30837836; Score: 0.44
DE  Interaction: P58512; IntAct: EBI-30837825; Score: 0.44
DE  Interaction: P52272; IntAct: EBI-30837804; Score: 0.44
DE  Interaction: P51946; IntAct: EBI-30837771; Score: 0.44
DE  Interaction: P36915; IntAct: EBI-30837760; Score: 0.44
DE  Interaction: P31271; IntAct: EBI-30837749; Score: 0.44
DE  Interaction: P0DP91; IntAct: EBI-30837738; Score: 0.44
DE  Interaction: P0DP72; IntAct: EBI-30837727; Score: 0.44
DE  Interaction: P03923; IntAct: EBI-30837716; Score: 0.44
DE  Interaction: O95819; IntAct: EBI-30837705; Score: 0.44
DE  Interaction: O75038; IntAct: EBI-30837694; Score: 0.44
DE  Interaction: O15069; IntAct: EBI-30837683; Score: 0.44
DE  Interaction: O00763; IntAct: EBI-30837672; Score: 0.44
DE  Interaction: O00555; IntAct: EBI-30837661; Score: 0.44
DE  Interaction: C9JE40; IntAct: EBI-30837650; Score: 0.44
DE  Interaction: Q15742; IntAct: EBI-30838001; Score: 0.44
DE  Interaction: Q2KJY2; IntAct: EBI-30838160; Score: 0.44
DE  Interaction: Q9Y2J4; IntAct: EBI-30838700; Score: 0.44
DE  Interaction: Q9Y2I8; IntAct: EBI-30838689; Score: 0.44
DE  Interaction: Q9Y2B5; IntAct: EBI-30838678; Score: 0.44
DE  Interaction: Q9ULI4; IntAct: EBI-30838667; Score: 0.44
DE  Interaction: Q9UJM3; IntAct: EBI-30838656; Score: 0.44
DE  Interaction: Q9UGK3; IntAct: EBI-30838645; Score: 0.44
DE  Interaction: Q9P2M7; IntAct: EBI-30838634; Score: 0.44
DE  Interaction: Q9P281; IntAct: EBI-30838623; Score: 0.44
DE  Interaction: Q9NX62; IntAct: EBI-30838612; Score: 0.44
DE  Interaction: Q9NSK0; IntAct: EBI-30838601; Score: 0.44
DE  Interaction: Q9NRP7; IntAct: EBI-30838590; Score: 0.44
DE  Interaction: Q9H2V7; IntAct: EBI-30838579; Score: 0.44
DE  Interaction: Q9BXF3; IntAct: EBI-30838557; Score: 0.44
DE  Interaction: Q9BWF2; IntAct: EBI-30838546; Score: 0.44
DE  Interaction: Q9BT40; IntAct: EBI-30838535; Score: 0.44
DE  Interaction: Q9BQE5; IntAct: EBI-30838513; Score: 0.44
DE  Interaction: Q96T23; IntAct: EBI-30838502; Score: 0.44
DE  Interaction: Q96J42; IntAct: EBI-30838491; Score: 0.44
DE  Interaction: Q96HP0; IntAct: EBI-30838480; Score: 0.44
DE  Interaction: Q96EV8; IntAct: EBI-30838469; Score: 0.44
DE  Interaction: Q96C34; IntAct: EBI-30838458; Score: 0.44
DE  Interaction: Q96B70; IntAct: EBI-30838430; Score: 0.44
DE  Interaction: Q96A61; IntAct: EBI-30838419; Score: 0.44
DE  Interaction: Q969S9; IntAct: EBI-30838408; Score: 0.44
DE  Interaction: Q8WZ42; IntAct: EBI-30838397; Score: 0.44
DE  Interaction: Q8WY91; IntAct: EBI-30838386; Score: 0.44
DE  Interaction: Q8NCU7; IntAct: EBI-30838375; Score: 0.44
DE  Interaction: Q8N831; IntAct: EBI-30838364; Score: 0.44
DE  Interaction: Q8IYB4; IntAct: EBI-30838353; Score: 0.44
DE  Interaction: Q8IY63; IntAct: EBI-30838342; Score: 0.44
DE  Interaction: Q8IWJ2; IntAct: EBI-30838331; Score: 0.44
DE  Interaction: Q8IVH2; IntAct: EBI-30838320; Score: 0.44
DE  Interaction: Q86UD5; IntAct: EBI-30838309; Score: 0.44
DE  Interaction: Q86SG4; IntAct: EBI-30838298; Score: 0.44
DE  Interaction: Q76N32; IntAct: EBI-30838287; Score: 0.44
DE  Interaction: Q6ZRV2; IntAct: EBI-30838276; Score: 0.44
DE  Interaction: Q6UB35; IntAct: EBI-30838265; Score: 0.44
DE  Interaction: Q5VYV7; IntAct: EBI-30838254; Score: 0.44
DE  Interaction: Q5T7P6; IntAct: EBI-30838243; Score: 0.44
DE  Interaction: Q5T4T6; IntAct: EBI-30838226; Score: 0.44
DE  Interaction: Q5JTH9; IntAct: EBI-30838215; Score: 0.44
DE  Interaction: Q58A45; IntAct: EBI-30838204; Score: 0.44
DE  Interaction: Q53ET0; IntAct: EBI-30838193; Score: 0.44
DE  Interaction: Q3KQZ1; IntAct: EBI-30838182; Score: 0.44
DE  Interaction: P14652; IntAct: EBI-28997321; Score: 0.35
GO  GO:0000781;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005794;
GO  GO:0000139;
GO  GO:0097431;
GO  GO:0016604;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0000242;
GO  GO:0042393;
GO  GO:0003950;
GO  GO:1990404;
GO  GO:0008270;
GO  GO:0051301;
GO  GO:0007052;
GO  GO:0051028;
GO  GO:1904908;
GO  GO:1904357;
GO  GO:1904743;
GO  GO:0018105;
GO  GO:0018107;
GO  GO:0090263;
GO  GO:0051973;
GO  GO:1904355;
GO  GO:0032212;
GO  GO:0045944;
GO  GO:0006471;
GO  GO:0070213;
GO  GO:0070198;
GO  GO:0070212;
GO  GO:0000209;
GO  GO:0015031;
GO  GO:0032210;
GO  GO:0051225;
GO  GO:0016055;
TP  Membrane Topology: Peripheral; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:22864114};
SQ  MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRS
SQ  PDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVS
SQ  STAPLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGA
SQ  NVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALD
SQ  LADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDK
SQ  GGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL
SQ  RERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMT
SQ  PLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILS
SQ  ESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVP
SQ  LHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDL
SQ  LRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASY
SQ  GHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEA
SQ  LPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGL
SQ  EHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQS
SQ  VEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDER
SQ  HAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIG
SQ  RPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT
//