ID  O95295;
PN  SNARE-associated protein Snapin;
GN  SNAPIN;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Membrane {ECO:0000250|UniProtKB:Q9Z266}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Z266}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z266}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Z266}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:18167355, ECO:0000269|PubMed:19168546, ECO:0000269|PubMed:21102408}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Z266}. Lysosome membrane {ECO:0000305|PubMed:25898167}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305|PubMed:21102408}. Note=Colocalizes with NANOS1 and PUM2 in the perinuclear region of germ cells. {ECO:0000269|PubMed:19168546}.
DR  UNIPROT: O95295;
DR  UNIPROT: D3DV56;
DR  UNIPROT: Q5SXU8;
DR  Pfam: PF14712;
DR  OMIM: 607007;
DR  DisGeNET: 23557;
DE  Function: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE- mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:18167355, ECO:0000269|PubMed:25898167}.
DE  Reference Proteome: Yes;
DE  Interaction: A1L4K1; IntAct: EBI-24500672; Score: 0.56
DE  Interaction: Q9Y561; IntAct: EBI-296734; Score: 0.37
DE  Interaction: Q9NUP1; IntAct: EBI-465885; Score: 0.37
DE  Interaction: Q6QNY1; IntAct: EBI-465893; Score: 0.83
DE  Interaction: Q96EV8; IntAct: EBI-465897; Score: 0.82
DE  Interaction: P78537; IntAct: EBI-465910; Score: 0.76
DE  Interaction: Q9UL45; IntAct: EBI-466025; Score: 0.53
DE  Interaction: Q6QNY0; IntAct: EBI-466164; Score: 0.35
DE  Interaction: Q15796; IntAct: EBI-7225073; Score: 0.37
DE  Interaction: Q08345; IntAct: EBI-728871; Score: 0.00
DE  Interaction: O95163; IntAct: EBI-729336; Score: 0.00
DE  Interaction: P26641; IntAct: EBI-730846; Score: 0.00
DE  Interaction: P54257; IntAct: EBI-730849; Score: 0.00
DE  Interaction: Q92993; IntAct: EBI-730852; Score: 0.00
DE  Interaction: Q16891; IntAct: EBI-730855; Score: 0.00
DE  Interaction: O95251; IntAct: EBI-730858; Score: 0.00
DE  Interaction: Q96AW1; IntAct: EBI-733337; Score: 0.00
DE  Interaction: O60282; IntAct: EBI-733340; Score: 0.00
DE  Interaction: Q96R06; IntAct: EBI-733343; Score: 0.00
DE  Interaction: P11047; IntAct: EBI-735808; Score: 0.00
DE  Interaction: Q15849; IntAct: EBI-1573308; Score: 0.60
DE  Interaction: Q62668; IntAct: EBI-1573609; Score: 0.62
DE  Interaction: Q08850; IntAct: EBI-1573773; Score: 0.35
DE  Interaction: O70377; IntAct: EBI-1573773; Score: 0.35
DE  Interaction: Q16539; IntAct: EBI-2116941; Score: 0.00
DE  Interaction: Q96L14; IntAct: EBI-2554834; Score: 0.56
DE  Interaction: Q9D0F1; IntAct: EBI-2558810; Score: 0.40
DE  Interaction: Q6A065; IntAct: EBI-2563315; Score: 0.40
DE  Interaction: Q8CZZ7; IntAct: EBI-2855566; Score: 0.00
DE  Interaction: Q7Z465; IntAct: EBI-3943766; Score: 0.37
DE  Interaction: O75923; IntAct: EBI-5357023; Score: 0.50
DE  Interaction: Q9BZ29; IntAct: EBI-5656556; Score: 0.00
DE  Interaction: P13929; IntAct: EBI-5658499; Score: 0.00
DE  Interaction: P35609; IntAct: EBI-5664140; Score: 0.00
DE  Interaction: P05023; IntAct: EBI-5664157; Score: 0.00
DE  Interaction: O00499; IntAct: EBI-5664176; Score: 0.00
DE  Interaction: Q5VT25; IntAct: EBI-5664210; Score: 0.00
DE  Interaction: Q5SW79; IntAct: EBI-21644990; Score: 0.55
DE  Interaction: Q8N3K9; IntAct: EBI-5664244; Score: 0.00
DE  Interaction: P17661; IntAct: EBI-5664261; Score: 0.00
DE  Interaction: P50570; IntAct: EBI-5664279; Score: 0.00
DE  Interaction: Q03001; IntAct: EBI-5664296; Score: 0.00
DE  Interaction: Q9NV70; IntAct: EBI-21673234; Score: 0.35
DE  Interaction: Q8IWE2; IntAct: EBI-5664349; Score: 0.00
DE  Interaction: Q9H6L5; IntAct: EBI-5664367; Score: 0.00
DE  Interaction: Q14974; IntAct: EBI-5664409; Score: 0.00
DE  Interaction: Q04695; IntAct: EBI-5664449; Score: 0.00
DE  Interaction: P24043; IntAct: EBI-5664487; Score: 0.00
DE  Interaction: Q9UPN3; IntAct: EBI-5664521; Score: 0.00
DE  Interaction: Q7Z406; IntAct: EBI-5664555; Score: 0.00
DE  Interaction: P11055; IntAct: EBI-5664573; Score: 0.00
DE  Interaction: P12883; IntAct: EBI-5664609; Score: 0.00
DE  Interaction: Q14511; IntAct: EBI-5664643; Score: 0.00
DE  Interaction: Q15149; IntAct: EBI-5664660; Score: 0.00
DE  Interaction: Q15276; IntAct: EBI-5664677; Score: 0.00
DE  Interaction: Q9UJ41; IntAct: EBI-24270079; Score: 0.56
DE  Interaction: Q96Q15; IntAct: EBI-5664713; Score: 0.00
DE  Interaction: P11277; IntAct: EBI-5664730; Score: 0.00
DE  Interaction: Q01082; IntAct: EBI-5664785; Score: 0.00
DE  Interaction: O94826; IntAct: EBI-5664802; Score: 0.00
DE  Interaction: P09493; IntAct: EBI-5664819; Score: 0.00
DE  Interaction: P07951; IntAct: EBI-24798942; Score: 0.56
DE  Interaction: Q969Q1; IntAct: EBI-5664873; Score: 0.00
DE  Interaction: P62258; IntAct: EBI-5664890; Score: 0.00
DE  Interaction: P63104; IntAct: EBI-5664907; Score: 0.00
DE  Interaction: Q5S007; IntAct: EBI-8752670; Score: 0.66
DE  Interaction: P60881; IntAct: EBI-8753069; Score: 0.40
DE  Interaction: H7BX26; IntAct: EBI-11021989; Score: 0.35
DE  Interaction: Q96NL6; IntAct: EBI-11396361; Score: 0.27
DE  Interaction: P48039; IntAct: EBI-11576732; Score: 0.00
DE  Interaction: P08779; IntAct: EBI-24330490; Score: 0.56
DE  Interaction: Q9UBB9; IntAct: EBI-24341172; Score: 0.56
DE  Interaction: Q7Z3Y8; IntAct: EBI-24484835; Score: 0.56
DE  Interaction: P19012; IntAct: EBI-24486820; Score: 0.56
DE  Interaction: P08727; IntAct: EBI-24509579; Score: 0.56
DE  Interaction: Q7Z3Y9; IntAct: EBI-22754657; Score: 0.56
DE  Interaction: P51946; IntAct: EBI-22754942; Score: 0.56
DE  Interaction: Q63ZY3; IntAct: EBI-24665653; Score: 0.56
DE  Interaction: Q12934; IntAct: EBI-24669400; Score: 0.56
DE  Interaction: Q9Y3C0; IntAct: EBI-24672862; Score: 0.56
DE  Interaction: Q9H1M0; IntAct: EBI-24680175; Score: 0.56
DE  Interaction: Q7Z6G3; IntAct: EBI-24691932; Score: 0.56
DE  Interaction: P49585; IntAct: EBI-24694444; Score: 0.56
DE  Interaction: Q8N9N5; IntAct: EBI-23767493; Score: 0.56
DE  Interaction: P20700; IntAct: EBI-24720012; Score: 0.56
DE  Interaction: Q8IV53; IntAct: EBI-23774805; Score: 0.56
DE  Interaction: P06753; IntAct: EBI-23779263; Score: 0.56
DE  Interaction: P67936; IntAct: EBI-24766526; Score: 0.56
DE  Interaction: Q70UQ0; IntAct: EBI-24768892; Score: 0.67
DE  Interaction: Q13515; IntAct: EBI-24778153; Score: 0.56
DE  Interaction: Q68D86; IntAct: EBI-24778626; Score: 0.56
DE  Interaction: P35900; IntAct: EBI-24793035; Score: 0.56
DE  Interaction: Q5JTB6; IntAct: EBI-25276210; Score: 0.56
DE  Interaction: Q9NYB9; IntAct: EBI-24602317; Score: 0.56
DE  Interaction: Q99816; IntAct: EBI-23929943; Score: 0.56
DE  Interaction: Q9UPT5; IntAct: EBI-25288795; Score: 0.56
DE  Interaction: Q2M2I5; IntAct: EBI-24455909; Score: 0.60
DE  Interaction: Q2T9L4; IntAct: EBI-24558210; Score: 0.56
DE  Interaction: Q96BD8; IntAct: EBI-24594639; Score: 0.56
DE  Interaction: Q8IYW4; IntAct: EBI-25161488; Score: 0.56
DE  Interaction: Q9Y5B8; IntAct: EBI-24760105; Score: 0.56
DE  Interaction: A1L168; IntAct: EBI-24806766; Score: 0.56
DE  Interaction: Q86WT6; IntAct: EBI-21541317; Score: 0.35
DE  Interaction: Q8TDR4; IntAct: EBI-21617027; Score: 0.35
DE  Interaction: Q9Y2V7; IntAct: EBI-21673529; Score: 0.35
DE  Interaction: Q9UJT2; IntAct: EBI-21696311; Score: 0.35
DE  Interaction: Q9NX95; IntAct: EBI-21720503; Score: 0.35
DE  Interaction: O60296; IntAct: EBI-21729552; Score: 0.35
DE  Interaction: Q8WVE6; IntAct: EBI-21754350; Score: 0.35
DE  Interaction: Q9UIL1; IntAct: EBI-21762105; Score: 0.35
DE  Interaction: Q07866; IntAct: EBI-21768919; Score: 0.35
DE  Interaction: A5D8V7; IntAct: EBI-21779481; Score: 0.35
DE  Interaction: Q8N7C3; IntAct: EBI-21782264; Score: 0.35
DE  Interaction: Q96GS4; IntAct: EBI-21795617; Score: 0.35
DE  Interaction: Q5T0J7; IntAct: EBI-21813461; Score: 0.35
DE  Interaction: Q8TDM0; IntAct: EBI-21813727; Score: 0.35
DE  Interaction: P51151; IntAct: EBI-16798325; Score: 0.27
DE  Interaction: O43493; IntAct: EBI-16800265; Score: 0.27
DE  Interaction: Q19QW5; IntAct: EBI-25649498; Score: 0.37
DE  Interaction: Q7TLC7; IntAct: EBI-26377368; Score: 0.35
DE  Interaction: P26583; IntAct: EBI-26436206; Score: 0.37
GO  GO:0001669;
GO  GO:0070161;
GO  GO:1904115;
GO  GO:0031083;
GO  GO:0099078;
GO  GO:0098574;
GO  GO:0005829;
GO  GO:0000139;
GO  GO:0002177;
GO  GO:0048471;
GO  GO:0030141;
GO  GO:0045202;
GO  GO:0008021;
GO  GO:0030672;
GO  GO:0000149;
GO  GO:0008089;
GO  GO:0048490;
GO  GO:0097352;
GO  GO:0008333;
GO  GO:0006886;
GO  GO:1902774;
GO  GO:0007042;
GO  GO:0032418;
GO  GO:0007040;
GO  GO:0032438;
GO  GO:0010977;
GO  GO:0070050;
GO  GO:0031175;
GO  GO:0007269;
GO  GO:0072384;
GO  GO:1902824;
GO  GO:0051604;
GO  GO:0031503;
GO  GO:0051036;
GO  GO:0062196;
GO  GO:0043393;
GO  GO:2000300;
GO  GO:0008090;
GO  GO:0016079;
GO  GO:0031629;
GO  GO:0016188;
GO  GO:0048489;
GO  GO:0072553;
TP  Membrane Topology: Peripheral; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:Q9Z266};
SQ  MAGAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDP
SQ  YVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDSGIYPPGSPGK
//