ID  O96018;
PN  Amyloid-beta A4 precursor protein-binding family A member 3;
GN  APBA3;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:19726677}.
DR  UNIPROT: O96018;
DR  UNIPROT: O60483;
DR  UNIPROT: Q9UPZ2;
DR  PDB: 2YT7;
DR  PDB: 2YT8;
DR  PDB: 5UWS;
DR  Pfam: PF00595;
DR  Pfam: PF00640;
DR  PROSITE: PS50106;
DR  PROSITE: PS01179;
DR  OMIM: 604262;
DR  DisGeNET: 9546;
DE  Function: May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN. {ECO:0000269|PubMed:19726677}.
DE  Reference Proteome: Yes;
DE  Interaction: P11274; IntAct: EBI-7358205; Score: 0.61
DE  Interaction: P00533; IntAct: EBI-7877395; Score: 0.44
DE  Interaction: Q9QYP6; IntAct: EBI-6115837; Score: 0.50
DE  Interaction: A7MCY6; IntAct: EBI-6116450; Score: 0.50
DE  Interaction: Q92844; IntAct: EBI-6116592; Score: 0.50
DE  Interaction: Q9H6Z9; IntAct: EBI-12503146; Score: 0.35
DE  Interaction: P16152; IntAct: EBI-11153984; Score: 0.35
DE  Interaction: Q6P5F9; IntAct: EBI-11603310; Score: 0.35
DE  Interaction: Q96P71; IntAct: EBI-15098872; Score: 0.60
DE  Interaction: Q8NCP5; IntAct: EBI-15098805; Score: 0.37
DE  Interaction: Q06481; IntAct: EBI-15098809; Score: 0.37
DE  Interaction: P78545; IntAct: EBI-15098813; Score: 0.37
DE  Interaction: P14061; IntAct: EBI-15098817; Score: 0.37
DE  Interaction: Q9UN79; IntAct: EBI-15098821; Score: 0.37
DE  Interaction: Q9H6I2; IntAct: EBI-15098825; Score: 0.37
DE  Interaction: P52747; IntAct: EBI-15098829; Score: 0.37
DE  Interaction: Q9NWT6; IntAct: EBI-15099018; Score: 0.75
DE  Interaction: P78552; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: Q9UHD2; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: Q9NSD9; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: Q9H6S1; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: Q9BY42; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: Q9BSJ5; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: Q99590; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: Q99569; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: Q8TEU7; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: Q8TBX8; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: Q8N9R8; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: Q6PD62; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: Q6P5Z2; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: Q5JTD0; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: Q12986; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: Q08AH1; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: P55789; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: P29803; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: P17029; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: P05067; IntAct: EBI-25936284; Score: 0.56
DE  Interaction: O94985; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: O75319; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: Q96BW9; IntAct: EBI-21604776; Score: 0.35
DE  Interaction: P32320; IntAct: EBI-21622979; Score: 0.35
DE  Interaction: Q86VW1; IntAct: EBI-21721972; Score: 0.35
DE  Interaction: Q9BZB8; IntAct: EBI-21821951; Score: 0.35
DE  Interaction: Q9H492; IntAct: EBI-30828353; Score: 0.44
DE  Interaction: Q93009; IntAct: EBI-30841267; Score: 0.44
GO  GO:0005737;
GO  GO:0043197;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0001540;
GO  GO:0019899;
GO  GO:0004857;
GO  GO:0007268;
GO  GO:0001701;
GO  GO:0043086;
GO  GO:0015031;
GO  GO:0010468;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MDFPTISRSPSGPPAMDLEGPRDILVPSEDLTPDSQWDPMPGGPGSLSRMELDESSLQELVQQFEALPGDLVGPSPGGAP
SQ  CPLHIATGHGLASQEIADAHGLLSAEAGRDDLLGLLHCEECPPSQTGPEEPLEPAPRLLQPPEDPDEDSDSPEWVEGASA
SQ  EQEGSRSSSSSPEPWLETVPLVTPEEPPAGAQSPETLASYPAPQEVPGPCDHEDLLDGVIFGARYLGSTQLVSERNPPTS
SQ  TRMAQAREAMDRVKAPDGETQPMTEVDLFVSTKRIKVLTADSQEAMMDHALHTISYTADIGCVLVLMARRRLARRPAPQD
SQ  HGRRLYKMLCHVFYAEDAQLIAQAIGQAFAAAYSQFLRESGIDPSQVGVHPSPGACHLHNGDLDHFSNSDNCREVHLEKR
SQ  RGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLAACQAAVRETKSQTSVTLSIVHC
SQ  PPVTTAIIHRPHAREQLGFCVEDGIICSLLRGGIAERGGIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIKTMPA
SQ  ATYRLLTGQEQPVYL
//