ID  P03247;
PN  E1B protein, small T-antigen;
GN  E1B;
OS  10515;
SL  Nucleus Position: SL-0415;
SL  Nucleus Position: SL-0416;
SL  Comments: Host cell membrane {ECO:0000250}. Host nucleus envelope {ECO:0000250}. Host nucleus lamina {ECO:0000250}. Note=Associated with the plasma and nuclear membranes, and with the insoluble nuclear lamina. {ECO:0000250}.
DR  UNIPROT: P03247;
DR  Pfam: PF01691;
DR  PROSITE: PS50062;
DE  Function: Putative adenovirus Bcl-2 homolog that inhibits apoptosis induced by TNF or FAS pathways, as well as p53-mediated apoptosis. Without E1B 19K function, virus production is compromised because of premature death of host cell. Interacts with Bax protein in cell lysates (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
DE  Interaction: O60238; IntAct: EBI-849900; Score: 0.65
DE  Interaction: P02545; IntAct: EBI-849870; Score: 0.37
DE  Interaction: Q16611; IntAct: EBI-849884; Score: 0.37
DE  Interaction: Q12982; IntAct: EBI-849887; Score: 0.37
DE  Interaction: Q12983; IntAct: EBI-849890; Score: 0.49
GO  GO:0044165;
GO  GO:0044199;
GO  GO:0044203;
GO  GO:0020002;
GO  GO:0016020;
GO  GO:0019050;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MEAWECLEDFSAVRNLLEQSSNSTSWFWRFLWGSSQAKLVCRIKEDYKWEFEELLKSCGELFDSLNLGHQALFQEKVIKT
SQ  LDFSTPGRAAAAVAFLSFIKDKWSEETHLSGGYLLDFLAMHLWRAVVRHKNRLLLLSSVRPAIIPTEEQQQEEARRRRRQ
SQ  EQSPWNPRAGLDPRE
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