ID  P05783;
PN  Keratin, type I cytoskeletal 18;
GN  KRT18;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Nucleus matrix {ECO:0000250|UniProtKB:Q5BJY9}. Cytoplasm, perinuclear region. Nucleus, nucleolus {ECO:0000269|PubMed:22002106}. Cytoplasm {ECO:0000250|UniProtKB:Q5BJY9}.
DR  UNIPROT: P05783;
DR  UNIPROT: Q53G38;
DR  UNIPROT: Q5U0N8;
DR  UNIPROT: Q9BW26;
DR  Pfam: PF00038;
DR  PROSITE: PS00226;
DR  PROSITE: PS51842;
DR  OMIM: 148070;
DR  OMIM: 215600;
DR  DisGeNET: 3875;
DE  Function: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}.
DE  Disease: Cirrhosis (CIRRH) [MIM:215600]: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension. {ECO:0000269|PubMed:12724528, ECO:0000269|PubMed:9011570}. Note=The disease is caused by variants affecting the gene represented in this entry.
DE  Reference Proteome: Yes;
DE  Interaction: O15027; IntAct: EBI-11083608; Score: 0.35
DE  Interaction: O75190; IntAct: EBI-1255173; Score: 0.62
DE  Interaction: P01112; IntAct: EBI-3930926; Score: 0.37
DE  Interaction: Q925J2; IntAct: EBI-7985760; Score: 0.53
DE  Interaction: P62993; IntAct: EBI-297464; Score: 0.35
DE  Interaction: P29353; IntAct: EBI-298042; Score: 0.27
DE  Interaction: P05787; IntAct: EBI-445615; Score: 0.94
DE  Interaction: P04049; IntAct: EBI-7291105; Score: 0.49
DE  Interaction: P63104; IntAct: EBI-7293055; Score: 0.67
DE  Interaction: Q9BVR6; IntAct: EBI-753352; Score: 0.37
DE  Interaction: P19012; IntAct: EBI-754231; Score: 0.55
DE  Interaction: O95751; IntAct: EBI-756694; Score: 0.37
DE  Interaction: Q8IYI6; IntAct: EBI-756712; Score: 0.37
DE  Interaction: Q15834; IntAct: EBI-757168; Score: 0.37
DE  Interaction: O14964; IntAct: EBI-758998; Score: 0.78
DE  Interaction: Q9Y5B8; IntAct: EBI-759004; Score: 0.67
DE  Interaction: O75688; IntAct: EBI-1060989; Score: 0.00
DE  Interaction: P23508; IntAct: EBI-1078134; Score: 0.00
DE  Interaction: P05452; IntAct: EBI-1085136; Score: 0.00
DE  Interaction: P02671; IntAct: EBI-1255726; Score: 0.37
DE  Interaction: P27348; IntAct: EBI-1255734; Score: 0.37
DE  Interaction: Q15628; IntAct: EBI-1371586; Score: 0.60
DE  Interaction: Q8NFJ9; IntAct: EBI-1805760; Score: 0.44
DE  Interaction: Q96RK4; IntAct: EBI-1805921; Score: 0.44
DE  Interaction: Q9BXC9; IntAct: EBI-1805991; Score: 0.44
DE  Interaction: Q8IWZ6; IntAct: EBI-1806052; Score: 0.44
DE  Interaction: Q99816; IntAct: EBI-2339235; Score: 0.67
DE  Interaction: Q8NFA0; IntAct: EBI-2513538; Score: 0.40
DE  Interaction: O46385; IntAct: EBI-7872249; Score: 0.37
DE  Interaction: P63103; IntAct: EBI-8673294; Score: 0.35
DE  Interaction: P63101; IntAct: EBI-8686577; Score: 0.35
DE  Interaction: P61981; IntAct: EBI-3453257; Score: 0.00
DE  Interaction: P28799; IntAct: EBI-3909889; Score: 0.37
DE  Interaction: Q9Y6K9; IntAct: EBI-3911087; Score: 0.57
DE  Interaction: Q14094; IntAct: EBI-3915486; Score: 0.37
DE  Interaction: Q9NUX5; IntAct: EBI-3917886; Score: 0.49
DE  Interaction: Q99459; IntAct: EBI-3926990; Score: 0.37
DE  Interaction: Q09472; IntAct: EBI-3929095; Score: 0.37
DE  Interaction: P52292; IntAct: EBI-3931399; Score: 0.37
DE  Interaction: O43913; IntAct: EBI-3931539; Score: 0.37
DE  Interaction: Q96GM5; IntAct: EBI-3931549; Score: 0.37
DE  Interaction: Q5VU43; IntAct: EBI-3931569; Score: 0.44
DE  Interaction: Q14161; IntAct: EBI-3931579; Score: 0.44
DE  Interaction: Q92837; IntAct: EBI-3934896; Score: 0.37
DE  Interaction: Q99757; IntAct: EBI-3938277; Score: 0.37
DE  Interaction: Q6PKC3; IntAct: EBI-3939414; Score: 0.37
DE  Interaction: Q8N2W9; IntAct: EBI-3939424; Score: 0.37
DE  Interaction: Q96MU7; IntAct: EBI-3939434; Score: 0.37
DE  Interaction: P15336; IntAct: EBI-5529812; Score: 0.35
DE  Interaction: Q12815; IntAct: EBI-5652482; Score: 0.31
DE  Interaction: Q13895; IntAct: EBI-5652463; Score: 0.31
DE  Interaction: P19320; IntAct: EBI-6190694; Score: 0.53
DE  Interaction: P02751; IntAct: EBI-6285956; Score: 0.35
DE  Interaction: P04792; IntAct: EBI-6871566; Score: 0.37
DE  Interaction: P13569; IntAct: EBI-6898303; Score: 0.53
DE  Interaction: Q99959; IntAct: EBI-9074403; Score: 0.40
DE  Interaction: Q13835; IntAct: EBI-9073560; Score: 0.58
DE  Interaction: P27958; IntAct: EBI-9350927; Score: 0.35
DE  Interaction: Q08379; IntAct: EBI-10194630; Score: 0.78
DE  Interaction: Q8IYE0; IntAct: EBI-10263041; Score: 0.56
DE  Interaction: Q96CS2; IntAct: EBI-10283572; Score: 0.56
DE  Interaction: P05783; IntAct: EBI-10483950; Score: 0.37
DE  Interaction: Q9D7I8; IntAct: EBI-11048266; Score: 0.35
DE  Interaction: P63167; IntAct: EBI-11051725; Score: 0.35
DE  Interaction: A0A0S2Z505; IntAct: EBI-16437711; Score: 0.56
DE  Interaction: P07196; IntAct: EBI-16437697; Score: 0.56
DE  Interaction: A0A0S2Z4Q4; IntAct: EBI-16437687; Score: 0.56
DE  Interaction: Q5JVL4; IntAct: EBI-24291369; Score: 0.56
DE  Interaction: Q3SY84; IntAct: EBI-24361934; Score: 0.56
DE  Interaction: P02538; IntAct: EBI-24367348; Score: 0.56
DE  Interaction: Q5XKE5; IntAct: EBI-24620654; Score: 0.56
DE  Interaction: Q9NX04; IntAct: EBI-24396239; Score: 0.56
DE  Interaction: P48668; IntAct: EBI-24419624; Score: 0.68
DE  Interaction: Q9P2K3; IntAct: EBI-24420285; Score: 0.56
DE  Interaction: Q9BVG8; IntAct: EBI-24553060; Score: 0.56
DE  Interaction: Q8WW24; IntAct: EBI-24557965; Score: 0.56
DE  Interaction: Q14533; IntAct: EBI-24563479; Score: 0.56
DE  Interaction: Q8TD31; IntAct: EBI-24572327; Score: 0.56
DE  Interaction: Q8N0S2; IntAct: EBI-12703058; Score: 0.56
DE  Interaction: O75022; IntAct: EBI-14032442; Score: 0.43
DE  Interaction: Q14457; IntAct: EBI-16020615; Score: 0.50
DE  Interaction: Q5SQX6; IntAct: EBI-16086797; Score: 0.35
DE  Interaction: Q9BQ69; IntAct: EBI-16880214; Score: 0.65
DE  Interaction: P61417; IntAct: EBI-20817152; Score: 0.37
DE  Interaction: P61416; IntAct: EBI-20817281; Score: 0.37
DE  Interaction: P68640; IntAct: EBI-20817402; Score: 0.37
DE  Interaction: O30878; IntAct: EBI-20817508; Score: 0.37
DE  Interaction: P69974; IntAct: EBI-20817667; Score: 0.37
DE  Interaction: A0A5P8YI02; IntAct: EBI-20818482; Score: 0.37
DE  Interaction: Q0WD22; IntAct: EBI-20818419; Score: 0.37
DE  Interaction: Q86U44; IntAct: EBI-20594935; Score: 0.35
DE  Interaction: Q9HCE5; IntAct: EBI-20595531; Score: 0.35
DE  Interaction: A0A087WXM9; IntAct: EBI-20917996; Score: 0.40
DE  Interaction: P08670; IntAct: EBI-20917772; Score: 0.40
DE  Interaction: Q5HYC2; IntAct: EBI-20918276; Score: 0.40
DE  Interaction: Q15149; IntAct: EBI-20919124; Score: 0.40
DE  Interaction: Q96M95; IntAct: EBI-20921148; Score: 0.40
DE  Interaction: Q12860; IntAct: EBI-20920940; Score: 0.40
DE  Interaction: Q8WWL7; IntAct: EBI-20922150; Score: 0.40
DE  Interaction: Q8WYP5; IntAct: EBI-20924394; Score: 0.40
DE  Interaction: Q8IYB4; IntAct: EBI-20926658; Score: 0.40
DE  Interaction: P01730; IntAct: EBI-20930576; Score: 0.40
DE  Interaction: Q9Y616; IntAct: EBI-20935164; Score: 0.40
DE  Interaction: Q9NY99; IntAct: EBI-20938524; Score: 0.40
DE  Interaction: Q66PJ3; IntAct: EBI-20938316; Score: 0.40
DE  Interaction: A2A935; IntAct: EBI-21022882; Score: 0.35
DE  Interaction: P14404; IntAct: EBI-21026252; Score: 0.35
DE  Interaction: Q14108; IntAct: EBI-21264396; Score: 0.35
DE  Interaction: B7UM99; IntAct: EBI-22228314; Score: 0.66
DE  Interaction: P61158; IntAct: EBI-22229062; Score: 0.27
DE  Interaction: Q96CS3; IntAct: EBI-25770166; Score: 0.35
DE  Interaction: Q8IWF2; IntAct: EBI-25770736; Score: 0.35
DE  Interaction: P42858; IntAct: EBI-25951430; Score: 0.56
DE  Interaction: P51114; IntAct: EBI-26510698; Score: 0.37
DE  Interaction: P51116; IntAct: EBI-26511933; Score: 0.37
DE  Interaction: Q53F19; IntAct: EBI-26396827; Score: 0.35
DE  Interaction: F1PAA9; IntAct: EBI-27079701; Score: 0.27
DE  Interaction: P35226; IntAct: EBI-27109494; Score: 0.35
DE  Interaction: Q9UNH5; IntAct: EBI-27115490; Score: 0.27
DE  Interaction: Q13283; IntAct: EBI-28955349; Score: 0.35
GO  GO:0005912;
GO  GO:0071944;
GO  GO:0034451;
GO  GO:0005737;
GO  GO:0005856;
GO  GO:0005829;
GO  GO:0070062;
GO  GO:0005882;
GO  GO:0045095;
GO  GO:0005815;
GO  GO:0005730;
GO  GO:0048471;
GO  GO:0098641;
GO  GO:0003723;
GO  GO:0097110;
GO  GO:0005198;
GO  GO:0009653;
GO  GO:0007049;
GO  GO:0097191;
GO  GO:0043000;
GO  GO:0097284;
GO  GO:0045104;
GO  GO:0043066;
GO  GO:0033209;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSFTTRSTFSTNYRSLGSVQAPSYGARPVSSAASVYAGAGGSGSRISVSRSTSFRGGMGSGGLATGIAGGLAGMGGIQNE
SQ  KETMQSLNDRLASYLDRVRSLETENRRLESKIREHLEKKGPQVRDWSHYFKIIEDLRAQIFANTVDNARIVLQIDNARLA
SQ  ADDFRVKYETELAMRQSVENDIHGLRKVIDDTNITRLQLETEIEALKEELLFMKKNHEEEVKGLQAQIASSGLTVEVDAP
SQ  KSQDLAKIMADIRAQYDELARKNREELDKYWSQQIEESTTVVTTQSAEVGAAETTLTELRRTVQSLEIDLDSMRNLKASL
SQ  ENSLREVEARYALQMEQLNGILLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRRLLEDGEDFNLGDALDSSN
SQ  SMQTIQKTTTRRIVDGKVVSETNDTKVLRH
//