ID  P05784;
PN  Keratin, type I cytoskeletal 18;
GN  Krt18;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Nucleus matrix {ECO:0000250|UniProtKB:Q5BJY9}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P05783}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P05783}. Cytoplasm {ECO:0000250|UniProtKB:Q5BJY9}.
DR  UNIPROT: P05784;
DR  UNIPROT: Q3TIX1;
DR  UNIPROT: Q3TJH6;
DR  UNIPROT: Q3TJW7;
DR  UNIPROT: Q61766;
DR  Pfam: PF00038;
DR  PROSITE: PS00226;
DR  PROSITE: PS51842;
DE  Function: When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:17213200}.
DE  Reference Proteome: Yes;
DE  Interaction: P63101; IntAct: EBI-8180960; Score: 0.35
DE  Interaction: Q64337; IntAct: EBI-10052425; Score: 0.38
GO  GO:0071944;
GO  GO:0034451;
GO  GO:0005737;
GO  GO:0005856;
GO  GO:0005829;
GO  GO:0009897;
GO  GO:0005615;
GO  GO:0005882;
GO  GO:0045095;
GO  GO:0005815;
GO  GO:0016363;
GO  GO:0005730;
GO  GO:0005886;
GO  GO:0032991;
GO  GO:0097110;
GO  GO:0005198;
GO  GO:0097191;
GO  GO:0043000;
GO  GO:0097284;
GO  GO:0045104;
GO  GO:0043066;
GO  GO:0033209;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSFTTRSTTFSTNYRSLGSVRTPSQRVRPASSAASVYAGAGGSGSRISVSRSVWGGSVGSAGLAGMGGIQTEKETMQDLN
SQ  DRLASYLDKVKSLETENRRLESKIREHLEKKGPQGVRDWGHYFKIIEDLRAQIFANSVDNARIVLQIDNARLAADDFRVK
SQ  YETELAMRQSVESDIHGLRKVVDDTNITRLQLETEIEALKEELLFMKKNHEEEVQGLEAQIASSGLTVEVDAPKSQDLSK
SQ  IMADIRAQYEALAQKNREELDKYWSQQIEESTTVVTTKSAEIRDAETTLTELRRTLQTLEIDLDSMKNQNINLENSLGDV
SQ  EARYKAQMEQLNGVLLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRRLLEDGEDFSLNDALDSSNSMQTVQK
SQ  TTTRKIVDGRVVSETNDTRVLRH
//