ID  P06703;
PN  Protein S100-A6;
GN  S100A6;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Comments: Nucleus envelope. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
DR  UNIPROT: P06703;
DR  UNIPROT: D3DV39;
DR  UNIPROT: Q5RHS4;
DR  PDB: 1K8U;
DR  PDB: 1K96;
DR  PDB: 1K9K;
DR  PDB: 1K9P;
DR  PDB: 2M1K;
DR  PDB: 4YBH;
DR  Pfam: PF01023;
DR  PROSITE: PS00018;
DR  PROSITE: PS50222;
DR  PROSITE: PS00303;
DR  OMIM: 114110;
DR  DisGeNET: 6277;
DE  Function: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. {ECO:0000269|PubMed:22399290}.
DE  Reference Proteome: Yes;
DE  Interaction: P03246; IntAct: EBI-11722343; Score: 0.35
DE  Interaction: P62993; IntAct: EBI-350217; Score: 0.35
DE  Interaction: P04271; IntAct: EBI-945511; Score: 0.65
DE  Interaction: P06703; IntAct: EBI-945542; Score: 0.37
DE  Interaction: P63104; IntAct: EBI-7198215; Score: 0.40
DE  Interaction: P26882; IntAct: EBI-7835180; Score: 0.59
DE  Interaction: Q02790; IntAct: EBI-7835253; Score: 0.59
DE  Interaction: Q00987; IntAct: EBI-8045742; Score: 0.56
DE  Interaction: P04637; IntAct: EBI-8045854; Score: 0.68
DE  Interaction: P52292; IntAct: EBI-8468931; Score: 0.61
DE  Interaction: Q3SYU7; IntAct: EBI-8469041; Score: 0.40
DE  Interaction: P52293; IntAct: EBI-8469341; Score: 0.40
DE  Interaction: P50542; IntAct: EBI-10194898; Score: 0.56
DE  Interaction: P0CK49; IntAct: EBI-11725356; Score: 0.35
DE  Interaction: Q2MG95; IntAct: EBI-11733653; Score: 0.35
DE  Interaction: P33215; IntAct: EBI-10993316; Score: 0.35
DE  Interaction: Q92544; IntAct: EBI-11126692; Score: 0.35
DE  Interaction: P26447; IntAct: EBI-11158347; Score: 0.35
DE  Interaction: O95619; IntAct: EBI-11158562; Score: 0.35
DE  Interaction: B3EWG5; IntAct: EBI-24644742; Score: 0.56
DE  Interaction: P61960; IntAct: EBI-21833372; Score: 0.40
DE  Interaction: Q9BUK0; IntAct: EBI-21833385; Score: 0.40
DE  Interaction: Q9NQG1; IntAct: EBI-21833398; Score: 0.35
DE  Interaction: Q9UPU7; IntAct: EBI-21833417; Score: 0.40
DE  Interaction: P27824; IntAct: EBI-16789225; Score: 0.27
DE  Interaction: P68431; IntAct: EBI-16793802; Score: 0.27
DE  Interaction: Q9BWW4; IntAct: EBI-21265722; Score: 0.35
DE  Interaction: P13569; IntAct: EBI-25416349; Score: 0.35
DE  Interaction: Q99963; IntAct: EBI-25376320; Score: 0.35
DE  Interaction: P29353; IntAct: EBI-25380474; Score: 0.35
DE  Interaction: P30086; IntAct: EBI-25381702; Score: 0.35
DE  Interaction: P15531; IntAct: EBI-25393623; Score: 0.35
DE  Interaction: P35579; IntAct: EBI-25400636; Score: 0.54
DE  Interaction: P32418; IntAct: EBI-25402569; Score: 0.44
DE  Interaction: Q9HB71; IntAct: EBI-25403594; Score: 0.54
DE  Interaction: Q96NB1; IntAct: EBI-25403823; Score: 0.40
DE  Interaction: Q8TD43; IntAct: EBI-25404225; Score: 0.54
DE  Interaction: Q15418; IntAct: EBI-25404661; Score: 0.44
DE  Interaction: Q9BUB5; IntAct: EBI-25404957; Score: 0.40
DE  Interaction: O95684; IntAct: EBI-25405095; Score: 0.54
DE  Interaction: P0DOF2; IntAct: EBI-25607852; Score: 0.35
DE  Interaction: P83105; IntAct: EBI-25745135; Score: 0.46
DE  Interaction: P60033; IntAct: EBI-25645944; Score: 0.35
DE  Interaction: Q13363; IntAct: EBI-27044482; Score: 0.35
DE  Interaction: P35226; IntAct: EBI-27109494; Score: 0.35
GO  GO:0062023;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0070062;
GO  GO:0005576;
GO  GO:0031234;
GO  GO:0005635;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0001726;
GO  GO:0005509;
GO  GO:0048306;
GO  GO:0015075;
GO  GO:0042803;
GO  GO:0044548;
GO  GO:0005523;
GO  GO:0008270;
GO  GO:0007409;
GO  GO:0048146;
GO  GO:0007165;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MACPLDQAIGLLVAIFHKYSGREGDKHTLSKKELKELIQKELTIGSKLQDAEIARLMEDLDRNKDQEVNFQEYVTFLGAL
SQ  ALIYNEALKG
//